Inhibition of coagulation and thrombin-induced platelet activities by a synthetic dodecapeptide modeled on the carboxy-terminus of hirudin

Kinetics of the inhibition of thrombin by hirudin

1986 • 581 citations

Antithrombin III Deficiency and Thromboembolism

1981 • 398 citations

Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone.

1988 • 274 citations

The measurement of thrombin in clotting blood by radioimmunoassay.

1976 • 235 citations

Anticoagulant Activity of Synthetic Hirudin Peptides

1989 • 203 citations

Cloning and expression of a cDNA coding for the anticoagulant hirudin from the bloodsucking leech, Hirudo medicinalis.

1986 • 198 citations

The complete amino acid sequence of hirudin, a thrombin specific inhibitor

1984 • 170 citations

The functional domain of hirudin, a thrombin‐specific inhibitor

1983 • 151 citations

Pharmacology of platelet-affecting drugs.

1980 • 103 citations

Cumulative antiplatelet effect of low‐dose enteric coated aspirin

1985 • 100 citations

The conformations of hirudin in solution: a study using nuclear magnetic resonance, distance geometry and restrained molecular dynamics

1987 • 99 citations

Heparin-induced Thrombocytopenia

1986 • 99 citations

Effect of thromboxane and serotonin receptor antagonists on intracoronary platelet deposition in dogs with experimentally stenosed coronary arteries.

1988 • 89 citations

Single amino acid substitutions in the reactive site of antithrombin leading to thrombosis. Congenital substitution of arginine 393 to cysteine in antithrombin Northwick Park and to histidine in antithrombin Glasgow.

1988 • 80 citations

Expression, secretion and processing of hirudin in E. coli using the alkaline phosphatase signal sequence

1986 • 78 citations

An Objective Assessment of the Interaction of Heparin and Its Fractions with Human Platelets

1985 • 70 citations

Modification of human platelet function by a diet enriched in saturated or polyunsaturated fat

1978 • 69 citations

Clinico-pharmacological studies with recombinant hirudin

1988 • 63 citations

Cloning and Expression in Escherichia coli of a Synthetic DNA for Hirudin, the Blood Coagulation Inhibitor in the Leech

1986 • 59 citations

Thrombin generation and secretion of platelet Factor 4 during blood clotting.

1978 • 55 citations

Platelet activation by thrombin in the absence of the high-affinity thrombin receptor

1988 • 44 citations

Heparin-Induced Thrombocytopenia

1986 • 43 citations

Heparin‐induced thrombocytopenia

1986 • 22 citations

Effect of thrombin inhibitors on thrombin-induced platelet release and aggregation

1988 • 14 citations

Further observations on the effects of dietary fatty acid composition on platelet reactivity and blood coagulation in man and the influence of methodology on findings

1982 • 6 citations

Deleted Work

1955 • 0 citations