Antibiotics and Hepatic Disease

A physiological approach to hepatic drug clearance

1975 • 1,855 citations

The Pharmacologic Basis of Therapeutics

1981 • 949 citations

The pharmacologic basis of therapeutics

1976 • 444 citations

Clinical Pharmacokinetics of Rifampicin

1978 • 397 citations

FACTORS AFFECTING DRUG METABOLISM

1971 • 342 citations

Protein Binding and Kinetics of Drugs in Liver Diseases

1977 • 262 citations

PHENYLBUTAZONE AND ISONIAZID METABOLISM IN PATIENTS WITH LIVER DISEASE IN RELATION TO PREVIOUS DRUG THERAPY

1968 • 196 citations

PERSISTENCE OF ANTIBIOTICS IN BLOOD OF PATIENTS WITH ACUTE RENAL FAILURE. II. CHLORAMPHENICOL AND ITS METABOLIC PRODUCTS IN THE BLOOD OF PATIENTS WITH SEVERE RENAL DISEASE OR HEPATIC CIRRHOSIS*†

1959 • 162 citations

INFLUENCE OF BINDING ON THE PHARMACOLOGIC ACTIVITY OF ANTIBIOTICS

1973 • 145 citations

Why Monitor Serum Levels of Gentamicin?

1978 • 133 citations

Diseases and Drug Protein Binding

1978 • 132 citations

Kinetics of rifampicin and isoniazid administered alone and in combination to normal subjects and patients with liver disease

1972 • 119 citations

PERSISTENCE OF ANTIBIOTICS IN BLOOD OF PATIENTS WITH ACUTE RENAL FAILURE. III. PENICILLIN, STREPTOMYCIN, ERYTHROMYCIN AND KANAMYCIN*†

1959 • 116 citations

Pharmacokinetics of the Penicillins in Man

1976 • 116 citations

Pathophysiological and Disease-Induced Changes in Drug Distribution Volume

1976 • 105 citations

Hepatic Disease and Drug Pharmacokinetics

1980 • 103 citations

Clearance and biologic half-life as indices of intrinsic hepatic metabolism.

1974 • 103 citations

Effect of rifampicin on liver function in man

1972 • 102 citations

Apparent volumes of distribution and drug binding to plasma proteins and tissues

1978 • 102 citations

Pharmacodynamics of Carbenicillin in Hepatic and Renal Failure

1970 • 89 citations

Chloramphenicol Toxicity in Liver and Renal Disease

1963 • 82 citations

INFLUENCE OF BINDING ON DRUG METABOLISM AND DISTRIBUTION*

1973 • 78 citations

Effect of plasma protein and tissue binding on the biologic half‐life of drugs

1978 • 75 citations

Pharmacokinetics of Ticarcillin in Patients with Abnormal Renal Function

1976 • 57 citations

Pharmacokinetics of ampicillin in cirrhosis

1975 • 56 citations

"Comparably Massive" Penicillin G Therapy in Renal Failure

1975 • 50 citations

Plasma Concentration of Chloramphenicol and Bone Marrow Suppression

1963 • 48 citations

Drug Pharmacokinetics in Cardiac and Hepatic Disease

1980 • 45 citations

Altered gentamicin distribution in ascitic patients

1979 • 43 citations

Chloramphenicol Pharmacokinetics in Hospitalized Patients

1979 • 40 citations

Theory and practical impact of binding of antimicrobials to serum proteins and tissue.

1978 • 38 citations

Elimination of chloramphenicol and thiamphenicol in subjects with cirrhosis of the liver.

1972 • 38 citations

Clinical Pharmacologic Studies with Minocycline

1971 • 38 citations

Chloramphenicol sodium succinate kinetics in critically ill patients

1980 • 34 citations

The effect of cirrhosis on the disposition and elimination of clindamycin

1975 • 33 citations

Parenteral Clindamycin Phosphate: Pharmacology with Normal and Abnormal Liver Function and Effect on Nasal Staphylococci

1975 • 26 citations

Half-Life of Rifampicin after Repeated Administration of Different Doses in Humans

1972 • 26 citations

Disposition of Nafcillin in Patients with Cirrhosis and Extrahepatic Biliary Obstruction

1977 • 24 citations

The influence of ascites on the pharmacokinetics of amikacin.

1980 • 21 citations

Drug Prescribing in Hepatobiliary Disease

1979 • 20 citations

Carbenicillin therapy in patients with normal and impaired renal function

1975 • 20 citations

The Influence of Liver Diseases on Drug Disposition

1979 • 19 citations

Displacement of Albumin-Bound Antimicrobial Agents by Bilirubin

1976 • 19 citations

Treatment of chronic drug-resistant pulmonary tuberculosis with rifampin and ethambutol.

1972 • 19 citations

Zur Pharmakokinetik von Clindamycin bei gestörter Leber- und Nierenfunktion

1972 • 19 citations

Use of Clindamycin in Patients with Liver Disease

1976 • 18 citations

TURNOVER AND DISTRIBUTION OF NAFCILLIN IN TISSUES AND BODY FLUIDS OF SURGICAL PATIENTS.

1964 • 14 citations

Elimination of Para-Aminosalicylic Acid in Patients with Liver Disease and Renal Insufficiency

1977 • 11 citations

Lincomycin metabolism in patients with hepatic insufficiency: effect of liver disease on lincomycin serum concentrations.

1966 • 9 citations

Antibiotics and the liver

1979 • 7 citations

呼吸器感染症を対象としたCefotiam (SCE-963) の基礎的, 臨床的研究

1979 • 5 citations