Hepatic Disease and Drug Pharmacokinetics

Clearance concepts in pharmacokinetics

1973 • 741 citations

FACTORS AFFECTING DRUG METABOLISM

1971 • 342 citations

Protein Binding and Kinetics of Drugs in Liver Diseases

1977 • 262 citations

Determinants of serum antipyrine half-lives in patients with liver disease

1973 • 178 citations

The effect of cirrhosis on the disposition and elimination of meperidine in man

1974 • 163 citations

PERSISTENCE OF ANTIBIOTICS IN BLOOD OF PATIENTS WITH ACUTE RENAL FAILURE. II. CHLORAMPHENICOL AND ITS METABOLIC PRODUCTS IN THE BLOOD OF PATIENTS WITH SEVERE RENAL DISEASE OR HEPATIC CIRRHOSIS*†

1959 • 162 citations

Intravenous administration of diazepam in patients with chronic liver disease.

1976 • 134 citations

Influence of viral hepatitis on the disposition of two compounds with high hepatic clearance: Lidocaine and indocyanine green

1976 • 65 citations

Effect of Acute Viral Hepatitis in Man on the Disposition and Elimination of Meperidine

1975 • 65 citations

Oral prednisone for chronic active liver disease: dose responses and bioavailability studies.

1978 • 61 citations

Metabolism of Drugs in Subjects with Laennec’s Cirrhosis

1959 • 60 citations

Effects of Chlorpromazine in Patients with Hepatic Disease

1969 • 51 citations

Hexobarbital disposition in compensated and decompensated cirrhosis of the liver

1978 • 46 citations

Plasma half‐life of phenylbutazone in patients with impaired liver function

1974 • 38 citations

Corticosteroid Pharmacokinetics in Liver Disease

1979 • 33 citations

Clinical Relevance of the Effect of Hepatic Disease on Drug Disposition

1978 • 16 citations

Liver Disease and Drug Therapy

1974 • 15 citations

Bioavailability and clearance of meperidine in patients with chronic liver disease

1979 • 3 citations

Activity and inducibility of hepatic microsomal enzymes in liver diseases.

1977 • 2 citations