Protein Binding and Kinetics of Drugs in Liver Diseases

A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

1909 • 6,516 citations

Arzneimittelforschung

2012 • 3,595 citations

Pharmacological Reviews

2024 • 2,716 citations

A physiological approach to hepatic drug clearance

1975 • 1,855 citations

Clearance concepts in pharmacokinetics

1973 • 741 citations

The effects of age and liver disease on the disposition and elimination of diazepam in adult man.

1975 • 693 citations

Pharmacokinetics of theophylline; Application to adjustment of the clinical dose of aminophylline

1972 • 507 citations

Lidocaine Pharmacokinetics in Advanced Heart Failure, Liver Disease, and Renal Failure in Humans

1973 • 504 citations

Binding of Drugs to Serum Albumin

1976 • 410 citations

Plasma and Tissue Protein Binding of Drugs in Pharmacokinetics

1976 • 375 citations

The Binding of Drugs by Plasma Proteins

1968 • 371 citations

THE USE OF ANTIPYRINE IN THE MEASUREMENT OF TOTAL BODY WATER IN MAN

1949 • 346 citations

FACTORS AFFECTING DRUG METABOLISM

1971 • 342 citations

Pharmacokinetics in the Elderly

1976 • 338 citations

Metabolic Interactions Among Environmental Chemicals and Drugs

1972 • 261 citations

Normal Disposition of Oxazepam in Acute Viral Hepatitis and Cirrhosis

1976 • 238 citations

Morphine metabolism in man

1974 • 228 citations

Effect of smoking on theophylline disposition

1976 • 228 citations

The Distribution and Excretion of Phenobarbital1

1957 • 225 citations

Altered Hepatic Blood Flow and Drug Disposition1

1976 • 209 citations

The disposition of propranolol. 3. Decreased half-life and volume of distribution as a result of plasma binding in man, monkey, dog and rat.

1973 • 205 citations

THE INTERACTIONS OF DRUGS AND PLASMA PROTEINS

1949 • 203 citations

Meperidine kinetics in man; Intravenous injection in surgical patients and volunteers

1975 • 201 citations

Assessment of Aminopyrine Metabolism in Man by Breath Analysis after Oral Administration of¹⁴C-Aminopyrine

1974 • 199 citations

PHENYLBUTAZONE AND ISONIAZID METABOLISM IN PATIENTS WITH LIVER DISEASE IN RELATION TO PREVIOUS DRUG THERAPY

1968 • 196 citations

The Disposition of Propranolol

1972 • 188 citations

Plasma protein binding of tricyclic anti-depressants in man

1969 • 184 citations

Clearance of Antipyrine‐Dependence of Quantitative Liver Function

1974 • 177 citations

Drug Dosage in Renal Disease

1976 • 173 citations

The fate of thiopental in man and a method for its estimation in biological material.

1950 • 172 citations

The effect of cirrhosis on the disposition and elimination of meperidine in man

1974 • 163 citations

OVERVIEW OF DRUG‐PROTEIN BINDING

1973 • 161 citations

Morphine and phenytoin binding to plasma proteins in renal and hepatic failure

1975 • 161 citations

Plasma protein binding of diphenylhydantoin Effects of sex hormones, renal and hepatic disease

1974 • 159 citations

Pharmacokinetics in the aged: A review

1975 • 158 citations

The Effect of Disease States on Drug Pharmacokinetics

1977 • 155 citations

Relationship between theophylline concentration in plasma and saliva of man

1974 • 149 citations

INFLUENCE OF DISEASE ON BINDING OF DRUGS TO PLASMA PROTEINS*

1973 • 147 citations

Serum protein binding as a determinant of warfarin body clearance and anticoagulant effect

1976 • 147 citations

Binding of digitoxin and some related cardenolides to human plasma proteins

1969 • 140 citations

Binding of Anilide-type Local Anesthetics in Human Plasma

1970 • 139 citations

Increased Clearance of Antipyrine and d-Propranolol after Phenobarbital Treatment in the Monkey

1974 • 134 citations

PHARMACOKINETIC DRUG INTERACTIONS

1969 • 133 citations

Diazepam and Paraldehyde for Treatment of Severe Delirium Tremens

1975 • 121 citations

The clearance of antipyrine and indocyanine green in normal subjects and in patients with chronic liver disease

1976 • 119 citations

Disposition of propranolol VI. Independent variation in steady‐state circulating drug concentrations and half‐life as a result of plasma drug binding in man

1973 • 110 citations

Plasma protein binding of diphenylhydantoin in normal and hyperbilirubinemic infants

1971 • 109 citations

Pathophysiological and Disease-Induced Changes in Drug Distribution Volume

1976 • 105 citations

Effects of route of administration and blood flow on hepatic drug elimination.

1975 • 104 citations

Clearance and biologic half-life as indices of intrinsic hepatic metabolism.

1974 • 103 citations

Drug Disposition and Liver Disease

1975 • 102 citations

Relationship of pentazocine plasma levels to pharmacological activity in man

1969 • 98 citations

Metabolism of amylobarbitone in patients with chronic liver disease

1972 • 90 citations

A study of factors influencing drug disposition in chronic liver disease, using the model drug (+)‐propranolol.

1976 • 89 citations

Morphine binding to human plasma proteins

1975 • 87 citations

Biochemical studies on chloramphenicol; tissue distribution and excretion studies.

1949 • 87 citations

The interactions of drugs and plasma proteins.

1949 • 85 citations

Comparison of plasma levels of antipyrine, tolbutamide, and warfarin after oral and intravenous administration

1974 • 80 citations

INFLUENCE OF BINDING ON DRUG METABOLISM AND DISTRIBUTION*

1973 • 78 citations

First‐pass metabolism of nortriptyline in man

1975 • 78 citations

Plasma Protein Binding of Thiopental in Patients with Impaired Renal or Hepatic Function

1975 • 76 citations

The Binding of Drugs to Plasma Proteins from Patients with Poor Renal Function

1976 • 75 citations

The binding of paracetamol to plasma proteins of man and pig

1973 • 74 citations

Effect of portacaval shunt on the disposition of drugs with and without first-pass effect.

1975 • 73 citations

Plasma Protein Binding of Diazepam and Tolbutamide in Chronic Alcoholics

1976 • 71 citations

Pharmacology and Pharmacokinetics

1974 • 70 citations

Plasma protein binding of chlorpromazine

1970 • 68 citations

Influence of acute viral hepatitis on disposition and plasma binding of tolbutamide

1977 • 67 citations

Absolute quinidine bioavailability

1976 • 67 citations

Influence of acute viral hepatitis on phenytoin kinetics and protein binding

1975 • 66 citations

Plasma Disappearance and Cerebral Effects of Chlorpromazine in Cirrhosis

1972 • 66 citations

Concentration of propoxyphene in human plasma following oral, intramuscular, and intravenous administration

1971 • 66 citations

Influence of viral hepatitis on the disposition of two compounds with high hepatic clearance: Lidocaine and indocyanine green

1976 • 65 citations

Effect of Acute Viral Hepatitis in Man on the Disposition and Elimination of Meperidine

1975 • 65 citations

Clinical toxicity of chloridazepoxide and diazepam in relation to serum albumin concentration: A report from the Boston collaborative drug surveillance Program

1974 • 64 citations

Metabolism and excretion of digitoxin in man

1974 • 64 citations

Pharmacokinetics of hexobarbital in acute hepatitis and after apparent recovery

1975 • 57 citations

Pharmacokinetics of ampicillin in cirrhosis

1975 • 56 citations

The protein binding of some drugs in plasma from patients with alcoholic liver disease

1975 • 55 citations

Serum Protein Binding of Erythromycin, Lincomycin, and Clindamycin

1973 • 53 citations

Comparative drug elimination capacity in man‐glutethimide, amobarbital, antipyrine, and sulfinpyrazone

1973 • 52 citations

The disposition of propranolol. 8. General implications of the effects of liver blood flow on elimination from the perfused rat liver.

1973 • 48 citations

Reciprocal Relation between Plasma Albumin Level and Hepatic Sulfobromophthalein Removal

1971 • 46 citations

Influence of acute viral hepatitis on disposition and pharmacologic effect of warfarin

1976 • 42 citations

THE EFFECT OF BARBITURATES IN PATIENTS WITH LIVER DISEASE 1

1954 • 39 citations

Elimination of chloramphenicol and thiamphenicol in subjects with cirrhosis of the liver.

1972 • 38 citations

The binding capacity of albumin and renal disease.

1974 • 37 citations

Data point weighting in pharmacokinetic analysis: intravenous paracetamol in man

1976 • 33 citations

Pharmacokinetics of saturably metabolized amobarbital

1974 • 32 citations

Pharmacokinetics of warfarin following intravenous administration to man.

1971 • 30 citations

Correlation of aryl hydrocarbon hydroxylase activity of human lymphocyte cultures and plasma elimination rates for antipyrine and phenylbutazone.

1975 • 28 citations

Decreased drug binding in serum from patients with chronic hepatic disease

1976 • 26 citations

THERAPEUTICS XII.

1970 • 20 citations

Use of Clindamycin in Patients with Liver Disease

1976 • 18 citations

Liver Disease and Drug Therapy

1974 • 15 citations

[Pharmacokinetics of glymidine (glycodiazine) and tolbutamide in acute and chronic liver diseases].

1973 • 13 citations

Pathophysiological Factors Influencing Drug Kinetics

1971 • 12 citations

Academy of Pharmaceutical Sciences

1974 • 11 citations

Pyocin antibiosis in chick embryos.

1969 • 9 citations

Paradoxical urinary excretion of o‐glucaric acid in acute viral hepatitis

1976 • 8 citations