Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells modulation of Fas/Fas ligand and caspase-3 pathway

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

1979 • 27,693 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Apoptosis by Death Factor

1997 • 5,038 citations

The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure

1996 • 4,580 citations

The Fas Death Factor

1995 • 4,070 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 • 1,207 citations

Norepinephrine Stimulates Apoptosis in Adult Rat Ventricular Myocytes by Activation of the β-Adrenergic Pathway

1998 • 690 citations

A rapid and simple method for the isolation of apoptotic DNA fragments

1994 • 660 citations

A License to Kill

1996 • 649 citations

Comparative Hemodynamic, Left Ventricular Functional, and Antiadrenergic Effects of Chronic Treatment With Metoprolol Versus Carvedilol in the Failing Heart

1996 • 455 citations

Autoproteolytic Activation of Pro-Caspases by Oligomerization

1998 • 424 citations

BCL-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapy

1996 • 420 citations

Primary Endothelial Dysfunction: Atherosclerosis

1999 • 417 citations

Requirement for the CD95 Receptor-Ligand Pathway in c-Myc-Induced Apoptosis

1997 • 370 citations

Upregulation of Superoxide Dismutase and Nitric Oxide Synthase Mediates the Apoptosis-Suppressive Effects of Shear Stress on Endothelial Cells

1999 • 299 citations

Induction of Endothelial Cell Apoptosis by TNFα: Modulation by Inhibitors of Protein Synthesis

1994 • 292 citations

Possible Involvement of Stress-Activated Protein Kinase Signaling Pathway and Fas Receptor Expression in Prevention of Ischemia/Reperfusion-Induced Cardiomyocyte Apoptosis by Carvedilol

1998 • 236 citations

Oxidized LDL activates fas-mediated endothelial cell apoptosis.

1998 • 230 citations

TNFα regulation of Fas ligand expression on the vascular endothelium modulates leukocyte extravasation

1998 • 215 citations

Peroxynitrite induces haem oxygenase-1 in vascular endothelial cells: a link to apoptosis

1999 • 194 citations

Fas ligation triggers apoptosis in macrophages but not endothelial cells

1994 • 192 citations

Secondary Endothelial Dysfunction: Hypertension and Heart Failure

1999 • 167 citations

Beneficial Effects of Intravenous and Oral Carvedilol Treatment in Acute Myocardial Infarction

1997 • 160 citations

Tolerability and efficacy of carvedilol in patients with New York Heart Association class IV heart failure

1999 • 110 citations

Carvedilol, a new antihypertensive agent, prevents lipid peroxidation and oxidative injury to endothelial cells.

1993 • 97 citations

Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity.

1993 • 83 citations

Proapoptotic effects of ANG II in human coronary artery endothelial cells: role of AT₁receptor and PKC activation

1999 • 79 citations

Monoamine-induced apoptotic neuronal cell death.

1997 • 66 citations

Endothelial dysfunction in the coronary microcirculation: a new clinical entity or an experimental finding?

1993 • 65 citations

γ-Tocopherol Decreases Ox-LDL-Mediated Activation of Nuclear Factor-κB and Apoptosis in Human Coronary Artery Endothelial Cells

1999 • 63 citations

Carvedilol, a new vasodilating adrenoceptor blocker antihypertensive drug, protects endothelial cells from damage initiated by xanthine-xanthine oxidase and neutrophils

1994 • 63 citations

Calcium and catecholamines: Relevance to cardiomyopathies and significance in therapeutic strategies

1985 • 58 citations

Myocardial and endothelial dysfunction after multiple, brief coronary occlusions: role of oxygen radicals

1992 • 49 citations

Tumor necrosis factor-α enhances hypoxia–reoxygenation-mediated apoptosis in cultured human coronary artery endothelial cells: critical role of protein kinase C

1999 • 35 citations

Carvedilol prevents low-density lipoprotein (LDL)-enhanced monocyte adhesion to endothelial cells by inhibition of LDL oxidation

1995 • 33 citations

Neurohumoral activations in congestive heart failure: Correlations with cardiac function, heart rate variability, and baroreceptor sensitivity

1999 • 32 citations

Characterization of β-Adrenoceptors in Pig Basilar Artery from Functional and Radioligand Binding Studies

1993 • 23 citations

Epinephrine-induced cytotoxicity of rat plasma. Its effects on isolated cardiac myocytes.

1988 • 13 citations

Norepinephrine-Induced Changes in Rat Heart Function, Metabolism, and Weight are Antagonized by Carvedilol

1993 • 3 citations