Examining the utility of patient-derived xenograft mouse models

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

2016 • 29,943 citations

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

2013 • 5,748 citations

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

2012 • 1,883 citations

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

2014 • 1,806 citations

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

2014 • 1,494 citations

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

2014 • 1,318 citations

Genome remodelling in a basal-like breast cancer metastasis and xenograft

2010 • 1,138 citations

Gemcitabine Plusnab-Paclitaxel Is an Active Regimen in Patients With Advanced Pancreatic Cancer: A Phase I/II Trial

2011 • 999 citations

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

2013 • 978 citations

PyClone: statistical inference of clonal population structure in cancer

2014 • 942 citations

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

2011 • 923 citations

A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer

2011 • 876 citations

Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials

2001 • 830 citations

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

2012 • 698 citations

Patient-derived models of acquired resistance can identify effective drug combinations for cancer

2014 • 686 citations

Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures

2014 • 655 citations

Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer

2013 • 607 citations

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

2014 • 586 citations

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity

2014 • 568 citations

A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-Derived Human Breast Cancer Xenograft Models

2013 • 422 citations

A New Model of Patient Tumor-Derived Breast Cancer Xenografts for Preclinical Assays

2007 • 392 citations

Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture

2014 • 388 citations

A Pilot Clinical Study of Treatment Guided by Personalized Tumorgrafts in Patients with Advanced Cancer

2011 • 383 citations

Characterization of a Large Panel of Patient-Derived Tumor Xenografts Representing the Clinical Heterogeneity of Human Colorectal Cancer

2012 • 335 citations

Establishment of Patient-Derived Non–Small Cell Lung Cancer Xenografts as Models for the Identification of Predictive Biomarkers

2008 • 276 citations

Stromal disrupting effects of nab-paclitaxel in pancreatic cancer

2013 • 265 citations

Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development

2004 • 218 citations

Tumor Engraftment in Nude Mice and Enrichment in Stroma- Related Gene Pathways Predict Poor Survival and Resistance to Gemcitabine in Patients with Pancreatic Cancer

2011 • 216 citations

Molecular profiling of patient-derived breast cancer xenografts

2012 • 177 citations

A Validated Tumorgraft Model Reveals Activity of Dovitinib Against Renal Cell Carcinoma

2012 • 174 citations

Orthotopic Transplantation Models of Pancreatic Adenocarcinoma Derived From Cell Lines and Primary Tumors and Displaying Varying Metastatic Activity

2004 • 160 citations

Global gene expression profiling confirms the molecular fidelity of primary tumor-based orthotopic xenograft mouse models of medulloblastoma

2012 • 148 citations

Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment

2014 • 145 citations

Primary resistance to cetuximab in a panel of patient-derived tumour xenograft models: Activation of MET as one mechanism for drug resistance

2011 • 134 citations

Patient-derived luminal breast cancer xenografts retain hormone receptor heterogeneity and help define unique estrogen-dependent gene signatures

2012 • 129 citations

A Model for Personalized in Vivo Analysis of Human Immune Responsiveness

2012 • 118 citations

Lurbinectedin (PM01183), a New DNA Minor Groove Binder, Inhibits Growth of Orthotopic Primary Graft of Cisplatin-Resistant Epithelial Ovarian Cancer

2012 • 90 citations

Phase II preclinical drug screening in human tumor xenografts: a first European multicenter collaborative study.

1992 • 87 citations

Prioritizing Phase I Treatment Options Through Preclinical Testing on Personalized Tumorgraft

2011 • 85 citations

Practices and Pitfalls of Mouse Cancer Models in Drug Discovery

2006 • 68 citations

Transcriptional dissection of pancreatic tumors engrafted in mice

2014 • 42 citations

Comparative Profiling of the Novel Epothilone, Sagopilone, in Xenografts Derived from Primary Non–Small Cell Lung Cancer

2010 • 38 citations

Preclinical Testing of Antileukemic Drugs Using an In Vivo Model of Systemic Disease

2005 • 12 citations