Genetic basis of the antibody repertoire in Xenopus: analysis of the Vh diversity.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

Supercoil Sequencing: A Fast and Simple Method for Sequencing Plasmid DNA

1985 • 2,505 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

A rapid single-stranded cloning strategy for producing a sequential series of overlapping clones for use in DNA sequencing: Application to sequencing the corn mitochondrial 18 S rDNA

1985 • 1,051 citations

A hyperconversion mechanism generates the chicken light chain preimmune repertoire

1987 • 693 citations

Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements

1984 • 669 citations

Mutation Drift and Repertoire Shift in the Maturation of the Immune Response

1987 • 635 citations

Development of the Primary Antibody Repertoire

1987 • 629 citations

Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence.

1984 • 564 citations

The immunoglobulin heavy chain variable region (Igh‐V) locus in the mouse. I. One hundred Igh‐V genes comprise seven families of homologous genes

1984 • 537 citations

Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus.

1988 • 432 citations

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity

1987 • 398 citations

Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma

1986 • 332 citations

A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production

1986 • 331 citations

Viral Integration and Excision: Structure of the Lambda att Sites

1977 • 281 citations

The Immune System of Xenopus

1989 • 261 citations

An enhancer-like sequence within the Xenopus U2 gene promoter facilitates the formation of stable transcription complexes

1985 • 250 citations

Organization and evolution of variable region genes of the human immunoglobulin heavy chain

1986 • 227 citations

Major reorganization of immunoglobulin VH segmental elements during vertebrate evolution

1986 • 223 citations

Two Pairs of Recombination Signals Are Sufficient to Cause Immunoglobulin V-(D)-J Joining

1987 • 222 citations

Patterns of Somatic Mutations in Immunoglobulin Variable Genes

1987 • 158 citations

Antibody diversity in lower vertebrates—why is it so restricted?

1982 • 151 citations

How do different transcription factors binding the same DNA sequence sort out their jobs?

1989 • 126 citations

Multiple DNA sequence elements are necessary for the function of an immunoglobulin heavy chain promoter.

1987 • 123 citations

Organization and rearrangement of immunoglobulin M genes in the amphibian Xenopus.

1988 • 85 citations

Amino acid sequence of heavy chain from Xenopus laevis IgM deduced from cDNA sequence: implications for evolution of immunoglobulin domains.

1988 • 84 citations

Organization of the murine immunoglobulin VH complex in the inbred strains.

1987 • 59 citations

Partial molecular genetic map of the rabbit VH chromosomal region.

1988 • 57 citations

Complete nucleotide sequences of three VH genes in Caiman, a phylogenetically ancient reptile: evolutionary diversification in coding segments and variation in the structure and organization of recombination elements.

1985 • 57 citations

Precursor immigration and thymocyte succession during larval development and metamorphosis in Xenopus.

1989 • 51 citations

Palindromic sequences are associated with sites of DNA breakage during gene conversion

1986 • 51 citations

Antibody diversity in amphibians: inheritance of isoelectric focusing antibody patterns in isogenic frogs

1978 • 46 citations

B-lymphocyte differentiation in Xenopus laevis larvae

1982 • 38 citations

Pecularities of immunoglobulin gene structures as a basis for somatic mutation emergence

1987 • 35 citations

Antibody diversity in amphibians: evidence for the inheritance of idiotypic specificities in isogenic Xenopus

1980 • 28 citations

The Ig germline gene repertoire: economy or wastage?

1988 • 20 citations

Immunoglobulin differentiation is dictated by repeated recombination sequences within the V region prototype gene: A hypothesis

1979 • 9 citations