Immunoglobulin differentiation is dictated by repeated recombination sequences within the V region prototype gene: A hypothesis

AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY

1970 • 1,308 citations

A complete immunoglobulin gene is created by somatic recombination.

1978 • 610 citations

DNA: Insertion Elements, Plasmids, and Episomes.

1977 • 530 citations

Sequences of mouse immunoglobulin light chain genes before and after somatic changes

1978 • 495 citations

Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain.

1978 • 419 citations

Purification and Properties of the recBC DNase of Escherichia coli K-12

1972 • 324 citations

Nucleotide sequence of an insertion element, IS1.

1978 • 319 citations

Organization of immunoglobulin heavy chain genes and allelic deletion model.

1978 • 297 citations

Viral Integration and Excision: Structure of the Lambda att Sites

1977 • 281 citations

Antigen-Binding Myeloma Proteins of Mice

1978 • 272 citations

Antibody Diversity

1978 • 240 citations

Amyloidosis: its nature and pathogenesis.

1973 • 215 citations

Is terminal deoxynucleotidyl transferase a somatic mutagen in lymphocytes?

1974 • 205 citations

Molecular Mechanism for Genetic Recombination

1972 • 133 citations

Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis.

1978 • 129 citations

Variable region genes for the immunoglobulin framework are assembled from small segments of DNA—A hypothesis

1978 • 107 citations

DNA clones containing mouse immunoglobulin kappa chain genes isolated by in vitro packaging into phage lambda coats.

1978 • 98 citations

Immunoglobulin biosynthesis

1970 • 37 citations

Amino acid sequence of the λ light chain of a human myeloma immunoglobulin (IgG new)

1974 • 37 citations

Single-strand scissions of chromosomal DNA during commitment to recombination at meiosis.

1975 • 32 citations

A human immunoglobulin G with deletions in both heavy and ligh polypeptide chains

1972 • 23 citations

Mechanism of conjugation and recombination in bacteria XVI

1977 • 8 citations