Ethylisopropylamiloride-sensitive pH control mechanisms modulate vascular smooth muscle cell growth

Adaptive Structural Changes of the Vascular Walls in Hypertension and their Relation to the Control of the Peripheral Resistance.

1958 • 511 citations

Pyrazine Diuretics. II. N-Amidino-3-amino-5-substituted 6-Halopyrazinecarboxamides

1967 • 323 citations

Blockade of the Na+/H+ antiport abolishes growth factor-induced DNA synthesis in fibroblasts. Structure-activity relationships in the amiloride series.

1984 • 305 citations

Cytoplasmic pH, a key determinant of growth factor‐induced DNA synthesis in quiescent fibroblasts

1985 • 247 citations

Growth factor activation of an amiloride-sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation.

1982 • 240 citations

Amiloride inhibits phorbol ester-stimulated Na+/H+ exchange and protein kinase C. An amiloride analog selectively inhibits Na+/H+ exchange.

1985 • 203 citations

Spontaneously hypertensive rat vascular smooth muscle cells in culture exhibit increased growth and Na+/H+ exchange.

1989 • 190 citations

Evidence for hyperplasia in mesenteric resistance vessels of spontaneously hypertensive rats using a three-dimensional disector.

1985 • 185 citations

Intracellular pH controls growth factor-induced ribosomal protein S6 phosphorylation and protein synthesis in the G0→G1 transition of fibroblasts

1986 • 126 citations

Bicarbonate and pHi response

1989 • 112 citations

Induction of v-mos and activated Ha-ras oncogene expression in quiescent NIH 3T3 cells causes intracellular alkalinisation and cell-cycle progression

1987 • 94 citations

Activation and proliferation signals in murine macrophages: Stimulation of Na⁺, K⁺‐ATPase activity by hemopoietic growth factors and other agents

1988 • 82 citations

The pH of spontaneously beating cultured rat heart cells is regulated by an ATP-calmodulin-dependent Na+/H+ antiport.

1989 • 75 citations

Bicarbonate determines cytoplasmic pH and suppresses mitogen-induced alkalinization in fibroblastic cells.

1988 • 71 citations

The relation of cycling of intracellular pH to mitosis in the acellular slime mould Physarum polycephalum

1977 • 69 citations

Dependence of Na+/H+ antiport activation in cultured rat aortic smooth muscle on calmodulin, calcium, and ATP. Evidence for the involvement of calmodulin-dependent kinases.

1988 • 69 citations

Amiloride sensitive activation of S6 kinase by angiotensin II in cultured vascular smooth muscle cells

1988 • 46 citations

Amiloride intercalates into DNA and inhibits DNA topoisomerase II.

1987 • 45 citations

Activation of Na+/H+ exchange and the expression of cellular proto-oncogenes in mitogen- and phorbol ester-treated lymphocytes.

1988 • 41 citations

Studies of hypertension-induced vascular hypertrophy in cultured smooth muscle cells from spontaneously hypertensive rats.

1983 • 36 citations

Demonstration of a late amiloride‐sensitive event as a necessary step in initiation of DNA synthesis by thrombin

1983 • 32 citations

Relationship of cytosolic ion fluxes and protein kinase C activation to platelet-derived growth factor induced competence and growth in BALB/c-3T3 cells

1989 • 27 citations