The pH of spontaneously beating cultured rat heart cells is regulated by an ATP-calmodulin-dependent Na+/H+ antiport.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

1978 • 2,146 citations

Relationship Between Carbohydrate and Lipid Metabolism and the Energy Balance of Heart Muscle

1974 • 1,252 citations

Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiace and skeletal muscles.

1978 • 1,086 citations

Cytoplasmic pH and free Mg2+ in lymphocytes.

1982 • 1,047 citations

Intracellular pH transients in squid giant axons caused by CO2, NH3, and metabolic inhibitors.

1976 • 913 citations

[65] Assays of intermediates of the citric acid cycle and related compounds by fluorometric enzyme methods

1969 • 872 citations

Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts

1983 • 721 citations

Mechanisms of regulation of the Na+/H+ exchanger

1986 • 685 citations

Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol.

1982 • 454 citations

Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH

1984 • 447 citations

1-(5-isoquinol inesulfonyl)-2-methylpiperazine (H-7) is a selective inhibitor of protein kinase c in rabbit platelets

1984 • 437 citations

Inhibition of calmodulin by phenothiazines and related drugs: structure-activity relationships.

1982 • 259 citations

Direct measurement of the intracellular pH of mammalian cardiac muscle.

1976 • 240 citations

Interactions between the regulation of the intracellular pH and sodium activity of sheep cardiac Purkinje fibres.

1980 • 210 citations

Intra- and extracellular actions of proton on the calcium current of isolated guinea pig ventricular cells.

1986 • 169 citations

Sodium/proton exchange in mouse neuroblastoma cells.

1981 • 166 citations

Digital image processing of intracellular pH in gastric oxyntic and chief cells

1987 • 145 citations

Na/H exchange in cultured chick heart cells. pHi regulation.

1985 • 138 citations

Uptake of 22Na+ by cultured dog kidney cells (MDCK).

1979 • 135 citations

Contribution of tissue acidosis to ischemic injury in the perfused rat heart.

1976 • 128 citations

Phorbol esters rapidly stimulate amiloride-sensitive Na+/H+ exchange in a human leukemic cell line.

1984 • 121 citations

Depletion of cellular ATP inhibits Na+/H+ antiport in cultured human cells. Modulation of the regulatory effect of intracellular protons on the antiporter activity.

1986 • 119 citations

Effects of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide and other calmodulin antagonists (calmodulin interacting agents) on calcium-induced contraction of rabbit aortic strips.

1981 • 116 citations

Relations among sodium pump inhibition, Na-Ca and Na-H exchange activities, and Ca-H interaction in cultured chick heart cells.

1987 • 112 citations

Chloride activity and its control in skeletal and cardiac muscle

1982 • 111 citations

The Use of Digitalis in Patients with Pulmonary Disease

1977 • 107 citations

The effects of intracellular protons on the electrical activity of single ventricular cells

1982 • 104 citations

Sodium‐dependent control of intracellular pH in Purkinje fibres of sheep heart.

1985 • 101 citations

The Na+/H+ antiport is activated by serum and phorbol esters in proliferating myoblasts but not in differentiated myotubes. Properties of the activation process.

1985 • 100 citations

Isoquinolinesulfonamides, Novel and Potent Inhibitors of Cyclic Nucleotide-Dependent Protein Kinase and Protein Kinase C

1984 • 98 citations

Influence of sodium‐hydrogen exchange on intracellular pH, sodium and tension in sheep cardiac Purkinje fibres.

1987 • 93 citations

Isoproterenol directly stimulates the Na+-K+ pump in isolated cardiac myocytes

1986 • 78 citations

Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors.

1986 • 77 citations

Na-H antiport in cultured rat aortic smooth muscle: its role in cytoplasmic pH regulation

1987 • 58 citations

Analysis of Cl- -HCO3(-) exchange during recovery from intracellular acidosis in cardiac Purkinje strands

1984 • 52 citations

Relationship between coronary flow and adenosine triphosphate production from glycolysis and oxidative metabolism.

1975 • 42 citations

Amiloride-induced changes in digoxin dynamics and kinetics: Abolition of digoxin-induced inotropism with amiloride

1981 • 40 citations

Mechanism of Isoprenaline-Induced Refractoriness of the β-Adrenoceptor—Adenylate Cyclase Syste in Chick Embryo Cardiac Cells

1981 • 39 citations

Possible effects of hydrogen ions in ischemic myocardium.

1976 • 24 citations

Effect of amiloride on digitalis-induced electrocardiographic changes.

1975 • 10 citations