Follicular lymphomas' BCL-2/IgH junctions contain templated nucleotide insertions: novel insights into the mechanism of t(14;18) translocation

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining

1985 • 1,021 citations

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1985 • 972 citations

Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

1998 • 785 citations

Molecular Cloning of the Chromosomal Breakpoint of B-Cell Lymphomas and Leukemias with the t(11;14) Chromosome Translocation

1984 • 671 citations

The Mechanism of V(D)J Joining: Lessons from Molecular, Immunological, and Comparative Analyses

1994 • 579 citations

DNA Transposition by the RAG1 and RAG2 Proteins

1998 • 532 citations

Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.

1988 • 499 citations

Lack of N Regions in Antigen Receptor Variable Region Genes of TdT-Deficient Lymphocytes

1993 • 474 citations

Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction.

1986 • 465 citations

Mice Lacking TdT: Mature Animals with an Immature Lymphocyte Repertoire

1993 • 437 citations

Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion

1999 • 372 citations

Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes.

1991 • 364 citations

Somatic hypermutation in normal and transformed human B cells

1998 • 351 citations

Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease

1998 • 347 citations

Thermostable DNA polymerase chain amplification of t(14;18) chromosome breakpoints and detection of minimal residual disease.

1988 • 341 citations

Mechanisms of nonhomologous recombination in mammalian cells.

1985 • 314 citations

Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, “minor” D segments or D-D recombination 1 1Edited By J. Karn

1997 • 300 citations

V(D)J Recombinase Activity in a Subset of Germinal Center B Lymphocytes

1997 • 284 citations

Neoteny in Lymphocytes: Rag1 and Rag2 Expression in Germinal Center B Cells

1996 • 272 citations

Somatic Hypermutation in the Heavy Chain Locus Correlates with Transcription

1998 • 265 citations

Somatic Hypermutation Introduces Insertions and Deletions into Immunoglobulin V Genes

1998 • 259 citations

TdT-Accessible Breaks Are Scattered over the Immunoglobulin V Domain in a Constitutively Hypermutating B Cell Line

1998 • 255 citations

V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses

1997 • 247 citations

Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners.

1987 • 236 citations

Reexpression of RAG-1 and RAG-2 Genes in Activated Mature Mouse B cells

1996 • 219 citations

Increased Frequency of N-Region Insertion in a Murine Pre-B-Cell Line Infected with a Terminal Deoxynucleotidyl Transferase Retroviral Expression Vector

1987 • 214 citations

Recent Advances in Understanding V(D)J Recombination

1997 • 196 citations

Antigen Receptor Engagement Turns off the V(D)J Recombination Machinery in Human Tonsil B Cells

1998 • 138 citations

Cryptic Signals and the Fidelity of V(D)J Joining

1997 • 133 citations

Comparison of filler DNA at immune, nonimmune, and oncogenic rearrangements suggests multiple mechanisms of formation.

1989 • 128 citations

Increased frequency of N-region insertion in a murine pre-B-cell line infected with a terminal deoxynucleotidyl transferase retroviral expression vector.

1987 • 125 citations

Evolution of B-cell malignancy: pre-B-cell leukemia resulting from MYC activation in a B-cell neoplasm with a rearranged BCL2 gene.

1988 • 121 citations

A DNA damage repair mechanism is involved in the origin of chromosomal translocations t(4;11) in primary leukemic cells

1999 • 115 citations

BCL2 oncogene translocation is mediated by a chi-like consensus.

1992 • 114 citations

Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): the DNA damage-repair model of translocation

1998 • 107 citations

Progress in understanding the mechanism and consequences of somatic hypermutation

1998 • 92 citations

Three lymphoid-specific factors account for all junctional diversity characteristic of somatic assembly of T-cell receptor and immunoglobulin genes.

1992 • 92 citations

Direct sequence analysis of the 14q+ and 18q- chromosome junctions in follicular lymphoma

1990 • 85 citations

The reciprocal partners of both the t(14; 18) and the t(11; 14) translocations involved in B-cell neoplasms are rearranged by the same mechanism.

1988 • 65 citations

V gene rearrangement is required to fully activate the hypermutation mechanism in B cells.

1989 • 64 citations

The role of short homology repeats and TdT in generation of the invariant γδ antigen receptor repertoire in the fetal thymus

1995 • 62 citations

Probing Immunoglobulin Gene Hypermutation with Microsatellites Suggests a Nonreplicative Short Patch DNA Synthesis Process

1998 • 53 citations

The VDJ repertoire expressed in human preB cells reflects the selection of bona fide heavy chains

1996 • 40 citations

The Composition of Coding Joints Formed in V(D)J Recombination Is Strongly Affected by the Nucleotide Sequence of the Coding Ends and Their Relationship to the Recombination Signal Sequences

1997 • 35 citations

Influence of the V(D)J recombination mechanism on the formation of the primary T and B cell repertoires

1994 • 34 citations

New type of t(14; 18) in a non‐Hodgkin's lymphoma provides insight in molecular events in early B‐cell differentiation

1995 • 23 citations

t(14;18) chromosomal translocation in follicular lymphoma: an event occurring with almost equal frequency both at the D to JH and at later stages in the rearrangement process of the immunoglobulin heavy chain gene locus

1997 • 20 citations