Progress in understanding the mechanism and consequences of somatic hypermutation

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

1997 • 1,091 citations

Maturation of the immune response in germinal centers

1991 • 904 citations

The role of clonal selection and somatic mutation in autoimmunity

1987 • 714 citations

Mutation ofBCL-6Gene in Normal B Cells by the Process of Somatic Hypermutation of Ig Genes

1998 • 536 citations

The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement

1994 • 415 citations

Structure and physical map of 64 variable segments in the 3′ 0.8–megabase region of the human immunoglobulin heavy–chain locus

1993 • 332 citations

Peanut lectin binding properties of germinal centers of mouse lymphoid tissue

1980 • 259 citations

CD40 Ligand and Appropriate Cytokines Induce Switching to IgG, IgA, and IgE and Coordinated Germinal Center and Plasmacytoid Phenotypic Differentiation in a Human Monoclonal IgM+IgD+ B Cell Line

1998 • 212 citations

Sequence and Evolution of the Human Germline VλRepertoire

1996 • 207 citations

Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells.

1996 • 175 citations

Biased immunoglobulin variable region gene expression by Ly‐1 B cells due to clonal selection

1989 • 145 citations

Induction of Somatic Mutation in a Human B Cell Line In Vitro

1997 • 141 citations

Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes.

1993 • 108 citations

A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B.

1990 • 104 citations

The molecular basis of somatic hypermutation of immunoglobulin genes

1996 • 100 citations

Physical Linkage of Mouse λ Genes by Pulsed-Field Gel Electrophoresis Suggests that the Rearrangement Process Favors Proximate Target Sequences

1989 • 67 citations

The preference for GT-rich DNA by the yeast Rad51 protein defines a set of universal pairing sequences

1997 • 66 citations

Organization of the Human Immunoglobulin Heavy-Chain Locus

1996 • 64 citations

REVIEW

1993 • 62 citations

Physical linkage of mouse lambda genes by pulsed-field gel electrophoresis suggests that the rearrangement process favors proximate target sequences.

1989 • 40 citations

B cells selected for apoptosis in the sheep ileal Peyer's patch have enhanced mutational diversity in the Ig V lambda light chain.

1996 • 15 citations