Cyclosporin A blocks 6-hydroxydopamine-induced efflux of Ca2+ from mitochondria without inactivating the mitochondrial inner-membrane pore

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1985 • 1,236 citations

The Generation of Hydrogen Peroxide, Superoxide Radical, and Hydroxyl Radical by 6-Hydroxydopamine, Dialuric Acid, and Related Cytotoxic Agents

1974 • 894 citations

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

1989 • 699 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

1992 • 443 citations

Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria

1987 • 332 citations

1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles

1990 • 323 citations

MPTP mechanisms of neurotoxicity and their implications for Parkinson's disease

1991 • 302 citations

Kinetic evidence for a heart mitochondrial pore activated by Ca²⁺, inorganic phosphate and oxidative stress

1988 • 293 citations

Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A

1991 • 261 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. II. The minimal requirements for pore induction underscore a key role for transmembrane electrical potential, matrix pH, and matrix Ca2+.

1993 • 225 citations

Oxidative stress as a cause of Parkinson's disease

1991 • 203 citations

Mechanism of the neurotoxicity of MPTP

1990 • 197 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. I. Evidence for two separate Me2+ binding sites with opposing effects on the pore open probability.

1993 • 191 citations

Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin

1992 • 189 citations

The reversible Ca2+-induced permeabilization of rat liver mitochondria

1986 • 174 citations

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) cause rapid ATP depletion in isolated hepatocytes

1986 • 167 citations

Ca2+ release from mitochondria induced by prooxidants

1988 • 166 citations

The permeability transition in heart mitochondria is regulated synergistically by ADP and cyclosporin A.

1992 • 146 citations

PREPARATION OF MITOCHONDRIA FROM ANIMAL TISSUES AND YEASTS

1972 • 138 citations

Thermodynamic control of electron flux through mitochondrial cytochrome bc1 complex

1985 • 109 citations

Current status of calcium in hepatocellular injury

1989 • 99 citations

Cyclosporin A protects hepatocytes subjected to high Ca²⁺ and oxidative stress

1992 • 96 citations

Permeability of inner mitochondrial membrane and oxidative stress

1988 • 94 citations

The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: Role of intracellular calcium

1988 • 87 citations

Relation of superoxide generation and lipid peroxidation to the inhibition of NADH-Q oxidoraductase by rotenone, piericidin A, and MPP+

1992 • 75 citations

N‐Methyl‐4‐phenylpyridine (MMP⁺ together with 6‐hydroxydopamine or dopamine stimulates Ca²⁺ release from mitochondria

1986 • 72 citations

N-acetyl-p-benzoquinone imine induces Ca2+ release from mitochondria by stimulating pyridine nucleotide hydrolysis.

1992 • 72 citations

‘Pore’ formation is not required for the hydroperoxide-induced Ca2+ release from rat liver mitochondria

1992 • 65 citations

Superoxide radical production during the autoxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium perchlorate.

1992 • 50 citations

Protection by cyclosporin A of cultured hepatocytes from the toxic consequences of the loss of mitochondrial energization produced by 1-methyl-4-phenylpyridinium

1992 • 41 citations

Neurotoxins and Neurodegenerative Diseases

1995 • 5 citations

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