Superoxide radical production during the autoxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium perchlorate.

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

1985 • 1,253 citations

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

1984 • 1,092 citations

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

1984 • 1,007 citations

The microestimation of succinate and the extinction coefficient of cytochrome c

1959 • 751 citations

1-Methyl-4-phenylpyridinium ion (MPP+): Identification of a metabolite of MPTP, a toxin selective to the substantia nigra

1984 • 423 citations

Pulse radiolytic investigations of superoxide catalyzed disproportionation. Mechanism for bovine superoxide dismutase

1973 • 252 citations

Absorption spectrum and decay kinetics of O2- and HO2 in aqueous solutions by pulse radiolysis

1969 • 226 citations

IV. Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects

1985 • 210 citations

Pulse Radiolysis Studies. V. Transient Spectra and Rate Constants in Oxygenated Aqueous Solutions¹

1964 • 147 citations

Depletion of glutathione in brainstem of mice caused by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is prevented by antioxidant pretreatment

1986 • 125 citations

Electrogeneration and some properties of the superoxide ion in aqueous solutions

1972 • 121 citations

Studies on the molecular mechanism of bioactivation of the selective nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1985 • 118 citations

Free radical reduction of ferricytochrome-c

1975 • 97 citations

The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metals

1985 • 96 citations

Reaction Constants of the Hydrated Electron

1963 • 93 citations

Studies on the 1-methyl-4-phenyl-2,3-dihydropyridinium species 2,3-MPDP+, the monoamine oxidase catalyzed oxidation product of the nitrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1985 • 68 citations

A catalyst function for MPTP in superoxide formation

1985 • 49 citations

The Ultraviolet Spectra of Transients Produced in the Radiolysis of Aqueous Solutions¹

1964 • 46 citations

III. Bioactivation of MPTP: Reactive metabolites and possible biochemical sequelae

1987 • 39 citations

Metabolic studies on the nigrostriatal toxin MPTP and its MAO B generated dihydropyridinium metabolite MPDP+

1988 • 38 citations

Brain Enzyme Is the Target of Drug Toxin

1984 • 36 citations

Chemically induced Parkinson's disease: Intermediates in the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to the 1-methyl-4-phenyl-pyridinium ion

1987 • 36 citations

Interactions of the 1-methyl-4-phenyl-2, 3-dihydropyridinium species with synthetic dopamine-melanin

1986 • 31 citations

The formation of reactive intermediates in the MAO-catalyzed oxidation of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1988 • 30 citations

Further insight into the mode of action of the neurotoxin 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)

1985 • 24 citations

Mechanism of oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+)

1987 • 16 citations

Characterization of a product derived from the 1-methyl-4-phenyl-2,3-dihydropyridinium ion, a metabolite of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1989 • 14 citations

Studies on 4-benzyl-1-methyl-1,2,3,6-tetrahydropyridine, a nonneurotoxic analog of the parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1990 • 12 citations

Evidence for the one-electron oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+)

1987 • 9 citations

Cited By (0)

Loading...