Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Mechanisms of angiogenesis

1997 • 5,696 citations

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

2000 • 2,700 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures.

1988 • 1,209 citations

Role of the Matrix Metalloproteinase and Plasminogen Activator–Plasmin Systems in Angiogenesis

2001 • 754 citations

Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro

1989 • 746 citations

[2] Families of serine peptidases

1994 • 621 citations

Activation of Matrix Metalloproteinase-9 (MMP-9) via a Converging Plasmin/Stromelysin-1 Cascade Enhances Tumor Cell Invasion

1999 • 583 citations

Angiogenesis promoted by vascular endothelial growth factor: Regulation through α₁β₁and α₂β₁ integrins

1997 • 516 citations

Type II Transmembrane Serine Proteases

2009 • 432 citations

Cellular Localization of Membrane-type Serine Protease 1 and Identification of Protease-activated Receptor-2 and Single-chain Urokinase-type Plasminogen Activator as Substrates

2000 • 432 citations

Differential gene expression during capillary morphogenesis in 3D collagen matrices

2001 • 397 citations

Activation of Hepatocyte Growth Factor and Urokinase/Plasminogen Activator by Matriptase, an Epithelial Membrane Serine Protease

2000 • 394 citations

An α2β1 Integrin-Dependent Pinocytic Mechanism Involving Intracellular Vacuole Formation and Coalescence Regulates Capillary Lumen and Tube Formation in Three-Dimensional Collagen Matrix

1996 • 352 citations

Type II Transmembrane Serine Proteases

2001 • 341 citations

Corin, a Mosaic Transmembrane Serine Protease Encoded by a Novel cDNA from Human Heart

1999 • 266 citations

Cloning of the TMPRSS2 Gene, Which Encodes a Novel Serine Protease with Transmembrane, LDLRA, and SRCR Domains and Maps to 21q22.3

1997 • 258 citations

Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia.

2001 • 256 citations

Reverse biochemistry: Use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue

1999 • 254 citations

Purification and Characterization of a Complex Containing Matriptase and a Kunitz-type Serine Protease Inhibitor from Human Milk

1999 • 243 citations

Functional Roles for PECAM-1 (CD31) and VE-Cadherin (CD144. in Tube Assembly and Lumen Formation in Three-Dimensional Collagen Gels

1999 • 243 citations

A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells.

1994 • 242 citations

Extracellular Cleavage of the Vascular Endothelial Growth Factor 189-Amino Acid Form by Urokinase Is Required for Its Mitogenic Effect

1997 • 240 citations

Plasminogen activator inhibitor from human fibrosarcoma cells binds urokinase-type plasminogen activator, but not its proenzyme.

1986 • 232 citations

Insertion of β-satellite repeats identifies a transmembrane protease causing both congenital and childhood onset autosomal recessive deafness

2001 • 226 citations

Matrix metalloproteinase-1 and -9 activation by plasmin regulates a novel endothelial cell-mediated mechanism of collagen gel contraction and capillary tube regression in three-dimensional collagen matrices

2001 • 225 citations

Angiogenesis: A Paradigm for Balanced Extracellular Proteolysis during Cell Migration and Morphogenesis

1996 • 220 citations

Characterization of a cDNA coding for human protein C.

1984 • 183 citations

Gene Expression Profiling in an in Vitro Model of Angiogenesis

2000 • 180 citations

Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains.

1994 • 177 citations

A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells

1988 • 174 citations

Human kallikrein 6 (zyme/protease M/neurosin): a new serum biomarker of ovarian carcinoma

2000 • 174 citations

Endoglin: An accessory component of the TGF‐β‐binding receptor‐complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies

2001 • 171 citations

Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like colon cancer cell lines HT-29 and Caco-2. Cloning of the complete human coding sequence and changes of dipeptidyl peptidase IV mRNA levels during cell differentiation.

1992 • 171 citations

Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils.

1990 • 171 citations

Matrix‐degrading proteases and angiogenesis during development and tumor formation

1999 • 169 citations

Expression of von Willebrand factor, an endothelial cell marker, is up-regulated by angiogenesis factors: A potential method for objective assessment of tumor angiogenesis

2000 • 168 citations

Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain

1997 • 168 citations

A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer.

2000 • 166 citations

Proteolytic control of growth factor availability

1999 • 157 citations

Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors

2000 • 157 citations

The Expanded Human Kallikrein (KLK) Gene Family: Genomic Organisation, Tissue-Specific Expression and Potential Functions

2001 • 146 citations

Growth factor–induced angiogenesis in vivo requires specific cleavage of fibrillar type I collagen

2001 • 144 citations

Molecular cloning of seprase: a serine integral membrane protease from human melanoma

1997 • 140 citations

Transgenic mouse models in angiogenesis and cardiovascular disease

2000 • 134 citations

Molecular Cloning, Tissue-specific Expression, and Cellular Localization of Human Prostasin mRNA

1995 • 127 citations

Neurotrypsin, a Novel Multidomain Serine Protease Expressed in the Nervous System

1997 • 117 citations

Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization.

1991 • 112 citations

Cloning and Characterization of the cDNA for Human Airway Trypsin-like Protease

1998 • 109 citations

An inhibitor of plasminogen activator in rabbit endothelial cells.

1981 • 108 citations

Hepsin, a Putative Membrane-associated Serine Protease, Activates Human Factor VII and Initiates a Pathway of Blood Coagulation on the Cell Surface Leading to Thrombin Formation

1995 • 108 citations

Molecular Characterization of Zyme/Protease M/Neurosin (PRSS9), A Hormonally Regulated Kallikrein-like Serine Protease

1999 • 105 citations

Testisin, a new human serine proteinase expressed by premeiotic testicular germ cells and lost in testicular germ cell tumors.

1999 • 104 citations

Signal relays in the VEGF system

1999 • 98 citations

Inhibition of Amyloid β-Protein Production in Neural Cells by the Serine Protease Inhibitor AEBSF

1996 • 87 citations

Role of fibrin and plasminogen activators in repair-associated angiogenesis: In Vitro studies with human endothelial cells

1997 • 78 citations

The Anticoagulant and Anti-inflammatory Roles of the Protein C Anticoagulant Pathway

2000 • 77 citations

Primary structure of human proacrosin deduced from its cDNA sequence

1989 • 70 citations

cDNA Sequence and Chromosomal Localization of Human Enterokinase, the Proteolytic Activator of Trypsinogen

1995 • 69 citations

Sequence Determinants of Function and Evolution in Serine Proteases

2000 • 68 citations

Cloning and expression of novel mosaic serine proteases with and without a transmembrane domain from human lung

2001 • 64 citations

Plasmin, Substilisin-like Endoproteases, Tissue Plasminogen Activator, and Urokinase Plasminogen Activator Are Involved in Activation of Latent TGF-β1in Human Seminal Plasma

1998 • 53 citations

Interaction of plasminogen with dipeptidyl peptidase IV initiates a signal transduction mechanism which regulates expression of matrix metalloproteinase-9 by prostate cancer cells

2001 • 51 citations

Proteolytic enzymes, past and present.

1985 • 50 citations

Primary Structure of Mouse Proacrosin Deduced from the cDNA Sequence and Its Gene Expression during Spermatogenesis

1990 • 42 citations

Cloning and Tissue Distribution of a Novel Serine Protease esp-1 from Human Eosinophils

1998 • 40 citations

Genetic Manipulation of Fibrinogen and Fibrinolysis in Mice

2001 • 36 citations

The VLA-2 (alpha 2 beta 1) I domain functions as a ligand-specific recognition sequence for endothelial cell attachment and spreading: molecular and functional characterization

1994 • 36 citations

Characterization of a plasminogen activator secreted by cultured bovine aortic endothelial cells

1982 • 35 citations

Properties of radiolabeled type I, II, and III collagens related to their use as substrates in collagenase assays

1986 • 34 citations

Cloning and sequencing of the cDNA encoding human neurotrypsin

1998 • 30 citations

A Novel Human Chymotrypsin-like Digestive Enzyme

1997 • 23 citations

A Role for Serine Proteases in Mediating Phorbol Ester-Induced Differentiation of HL-60 Cells

2000 • 13 citations

An in situ hybridization protocol to detect rare mRNA expressed in neural tissue using biotin-labelled oligonucleotide probes

2001 • 7 citations

Aprotinin: mechanism of action and therapeutical uses.

1980 • 2 citations