SIP1 (Smad interacting protein 1) and deltaEF1 (delta-crystallin enhancer binding factor) are structurally similar transcriptional repressors.

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

Prediction of the Coding Sequences of Unidentified Human Genes. IX. The Complete Sequences of 100 New cDNA Clones from Brain Which Can Code for Large Proteins in vitro

1998 • 848 citations

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

1998 • 838 citations

Noggin, Cartilage Morphogenesis, and Joint Formation in the Mammalian Skeleton

1998 • 810 citations

Crystal Structure of a Smad MH1 Domain Bound to DNA

1998 • 709 citations

A Smad Transcriptional Corepressor

1999 • 563 citations

Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

1998 • 513 citations

SIP1, a Novel Zinc Finger/Homeodomain Repressor, Interacts with Smad Proteins and Binds to 5′-CACCT Sequences in Candidate Target Genes

1999 • 492 citations

Convergence of Transforming Growth Factor-β and Vitamin D Signaling Pathways on SMAD Transcriptional Coactivators

1999 • 442 citations

Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects

1999 • 436 citations

OAZ Uses Distinct DNA- and Protein-Binding Zinc Fingers in Separate BMP-Smad and Olf Signaling Pathways

2000 • 428 citations

Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination

2000 • 393 citations

The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb

2000 • 391 citations

Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family

1996 • 387 citations

The oncoprotein Evi-1 represses TGF-β signalling by inhibiting Smad3

1998 • 369 citations

Evidence for a function of CtBP in epithelial gene regulation and anoikis

2000 • 338 citations

Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators

1998 • 320 citations

δEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages

1998 • 285 citations

ZEB represses transcription through interaction with the corepressor CtBP

1999 • 273 citations

New mode of DNA binding of multi-zinc finger transcription factors: delta EF1 family members bind with two hands to two target sites

1999 • 262 citations

The Drosophila Gene brinker Reveals a Novel Mechanism of Dpp Target Gene Regulation

1999 • 262 citations

Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors

1996 • 250 citations

Left–Right Asymmetric Expression of lefty2 and nodal Is Induced by a Signaling Pathway that Includes the Transcription Factor FAST2

2000 • 236 citations

brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes

1999 • 232 citations

Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity

2000 • 223 citations

Smad1 Recognition and Activation by the ALK1 Group of Transforming Growth Factor-β Family Receptors

1999 • 219 citations

The delta-crystallin enhancer-binding protein delta EF1 is a repressor of E2-box-mediated gene activation.

1994 • 219 citations

Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors.

1988 • 203 citations

schnurri is required for drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1

1995 • 200 citations

Identification of a Zinc Finger Protein that Inhibits IL-2 Gene Expression

1991 • 195 citations

Displacement of an E-Box-Binding Repressor by Basic HelixLoop-Helix Proteins: Implications for B-Cell Specificity of the Immunoglobulin Heavy-Chain Enhancer

1994 • 173 citations

Role of p300, a transcriptional coactivator, in signalling of TGF‐β

1998 • 162 citations

Targeted Disruption in Murine Cells Reveals Variable Requirement for Smad4 in Transforming Growth Factor β-related Signaling

2000 • 161 citations

Expression of EVI1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translocations

1994 • 153 citations

Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders.

1997 • 139 citations

Impairment of T Cell Development in δ EF1 Mutant Mice

1997 • 139 citations

Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors

2000 • 137 citations

TGF‐β receptors

1992 • 133 citations

Identification of CtBP1 and CtBP2 as Corepressors of Zinc Finger-Homeodomain Factor δEF1

1999 • 128 citations

Cloning and Functional Characterization of Roaz, a Zinc Finger Protein that Interacts with O/E-1 to Regulate Gene Expression: Implications for Olfactory Neuronal Development

1997 • 126 citations

A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signaling

1995 • 125 citations

Schnurri mediates Dpp-dependent repression of brinker transcription

2000 • 119 citations

The Interaction of the Carboxyl Terminus-binding Protein with the Smad Corepressor TGIF Is Disrupted by a Holoprosencephaly Mutation in TGIF

2000 • 106 citations

Independent Repressor Domains in ZEB Regulate Muscle and T-Cell Differentiation

1999 • 96 citations

Identification of Two Smad4 Proteins in Xenopus

1999 • 95 citations

Xenopus Smad4β Is the Co-Smad Component of Developmentally Regulated Transcription Factor Complexes Responsible for Induction of Early Mesodermal Genes

1999 • 92 citations

Region-specific activation of the Xenopus Brachyury promoter involves active repression in ectoderm and endoderm: a study using transgenic frog embryos

2000 • 90 citations

c-Myb and Ets proteins synergize to overcome transcriptional repression by ZEB

1997 • 86 citations

Two mechanisms in the action of repressor δEF1: binding site competition with an activator and active repression

1997 • 78 citations

The Zinc Finger Protein Schnurri Acts as a Smad Partner in Mediating the Transcriptional Response to Decapentaplegic

2000 • 72 citations

Transcription Factors Positively and Negatively Regulating the Na, K-ATPase α1 Subunit Gene1

1993 • 69 citations

Identification of nuclear factor δEF1 and its binding site essential for lens-specific activity of the δ1-crystallin enhancer

1991 • 68 citations

XSIP1, a Member of Two-Handed Zinc Finger Proteins, Induced Anterior Neural Markers in Xenopus laevis Animal Cap

2000 • 66 citations

Involvement of Negative Cofactor NC2 in Active Repression by Zinc Finger-Homeodomain Transcription Factor AREB6

1998 • 55 citations

XSIP1, a Xenopus zinc finger/homeodomain encoding gene highly expressed during early neural development

2000 • 52 citations

Spemann organizer activity of Smad10

1999 • 49 citations

BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription.

1994 • 48 citations

Alternative Splicing Gives Rise to Two Isoforms of Zfhep, a Zinc Finger/Homeodomain Protein That Binds T3-Response Elements

1996 • 35 citations

Schnurri interacts with Mad in a Dpp‐dependent manner

2000 • 32 citations

The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2

1992 • 30 citations