Extracellular Signal-Regulated Kinase Mediates Stimulation of TGF-β1 and Matrix by High Glucose in Mesangial Cells

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

The MAPK signaling cascade

1995 • 3,300 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Protein kinase C activation and the development of diabetic complications.

1998 • 1,328 citations

Luciferase reporter gene vectors for analysis of promoters and enhancers.

1988 • 1,016 citations

Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody indb/dbdiabetic mice

2000 • 907 citations

Neutralization of TGF-β by Anti-TGF-β Antibody Attenuates Kidney Hypertrophy and the Enhanced Extracellular Matrix Gene Expression in STZ-Induced Diabetic Mice

1996 • 658 citations

Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.

1990 • 647 citations

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

1992 • 647 citations

Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta.

1994 • 593 citations

Activation of ternary complex factor Elk-1 by MAP kinases.

1993 • 561 citations

Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.

1997 • 532 citations

High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells.

1998 • 418 citations

Characterization of the Promoter Region of the Human Transforming Growth Factor-β1 Gene

1989 • 400 citations

Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways

1999 • 386 citations

High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β

1992 • 353 citations

Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.

1989 • 324 citations

The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts.

1993 • 305 citations

Increased Renal Production of Transforming Growth Factor-β1 in Patients with Type II Diabetes

1997 • 275 citations

Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy

1994 • 273 citations

Elevated glucose stimulates TGF-β gene expression and bioactivity in proximal tubule

1992 • 264 citations

The Extracellular Matrix in Diabetic Nephropathy

1993 • 256 citations

Mitogen-Activated Protein Kinase Cascade Is Activated in Glomeruli of Diabetic Rats and Glomerular Mesangial Cells Cultured Under High Glucose Conditions

1997 • 233 citations

Diabetes Complications: Why Is Glucose Potentially Toxic?

1996 • 205 citations

High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule

1990 • 196 citations

TGF-β1 activates MAP kinase in human mesangial cells: A possible role in collagen expression

1999 • 187 citations

Construction and identification of cDNA clones for mouse ribosomal proteins: Application for the study of r-protein gene expression

1980 • 187 citations

Role for Protein Kinase C in the Mediation of Increased Fibronectin Accumulation by Mesangial Cells Grown in High-Glucose Medium

1993 • 178 citations

Multiple intracellular MAP kinase signaling cascades

1996 • 173 citations

Transcriptional activation of transforming growth factor-β1 in mesangial cell culture by high glucose concentration

1998 • 167 citations

Endothelin rapidly stimulates mitogen-activated protein kinase activity in rat mesangial cells

1992 • 163 citations

Cross-talk in signal transduction: TPA-inducible factor jun/AP-1 activates cAMP-responsive enhancer elements.

1990 • 162 citations

High Glucose Stimulates Proliferation and Collagen Type I Synthesis in Renal Cortical Fibroblasts

1999 • 143 citations

Characterization of the mouse transforming growth factor-beta 1 promoter and activation by the Ha-ras oncogene.

1991 • 131 citations

Glucose enhances type IV collagen production in cultured rat glomerular mesangial cells

1991 • 129 citations

Platelet-derived growth factor and angiotensin II stimulate the mitogen-activated protein kinase cascade in renal mesangial cells: comparison of hypertrophic and hyperplastic agonists

1995 • 114 citations

Biochemical events and cytokine interactions linking glucose metabolism to the development of diabetic nephropathy.

1997 • 114 citations

Therapy with antisense TGF-β1 oligodeoxynucleotides reduces kidney weight and matrix mRNAs in diabetic mice

2000 • 105 citations

Mechanisms of Mitogen-Activated Protein Kinase Activation in Experimental Diabetes

1999 • 105 citations

High glucose elevates c-fos and c-jun transcripts and proteins in mesangial cell cultures

1994 • 96 citations

PKC and high glucose stimulate collagen alpha 1 (IV) transcriptional activity in a reporter mesangial cell line

1994 • 88 citations

Advanced glycation endproducts stimulate the MAP‐kinase pathway in tubulus cell line LLC‐PK₁

1997 • 77 citations

Stretch-induced overproduction of fibronectin in mesangial cells is mediated by the activation of mitogen-activated protein kinase.

1999 • 76 citations

Effects of Polyol-Pathway Inhibition and Dietary myo-Inositol on Glomerular Hemodynamic Function in Experimental Diabetes Mellitus in Rats

1991 • 76 citations

Stimulation of TGF-β type II receptor by high glucose in mouse mesangial cells and in diabetic kidney

2000 • 73 citations

Effect of glucose on stress-activated protein kinase activity in mesangial cells and diabetic glomeruli

1999 • 64 citations

Protein kinase signalling pathways involved in the up-regulation of the rat α1(I) collagen gene by transforming growth factor β1 and bone morphogenetic protein 2 in osteoblastic cells

1999 • 61 citations

High glucose-induced TGF-beta 1 regulates mesangial production of heparan sulfate proteoglycan

1996 • 59 citations

Regulation of Glomerular Epithelial Cell Production of Fibronectin and Transforming Growth Factor-β by High Glucose, Not by Angiotensin II

1997 • 59 citations

Nitric oxide: a modulator for the epidermal growth factor receptor expression in developing ovarian granulosa cells

1996 • 57 citations

DNA binding of activator protein-1 is increased in human mesangial cells cultured in high glucose concentrations

1998 • 46 citations