Human Dopamine D₃Receptors Mediate Mitogen-Activated Protein Kinase Activation Via a Phosphatidylinositol 3-Kinase and an Atypical Protein Kinase C-Dependent Mechanism

Dopamine Receptors: From Structure to Function

1998 • 3,489 citations

Protein modules and signalling networks

1995 • 2,447 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976

1993 • 1,589 citations

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 • 971 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

1997 • 671 citations

Inhibition of protein kinase C μ by various inhibitors. Inhibition from protein kinase c isoenzymes

1996 • 633 citations

The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101

1997 • 549 citations

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

1995 • 541 citations

Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties.

1989 • 508 citations

cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.

1994 • 473 citations

Distinct Pathways of Gi- and Gq-mediated Mitogen-activated Protein Kinase Activation

1995 • 451 citations

Protein kinase C ζ isoform is critical for mitogenic signal transduction

1993 • 383 citations

The D3 dopamine receptor: neurobiology and potential clinical relevance.

1997 • 376 citations

Lipid second messengers

1994 • 357 citations

Signaling from G-Protein-coupled Receptors to Mitogen-activated Protein (MAP)-Kinase Cascades

1998 • 271 citations

Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta.

1994 • 221 citations

A functional test identifies dopamine agonists selective for D3 versus D2 receptors

1995 • 213 citations

Go-protein α-Subunits Activate Mitogen-activated Protein Kinase via a Novel Protein Kinase C-dependent Mechanism

1996 • 205 citations

Critical Role of Calcium- dependent Epidermal Growth Factor Receptor Transactivation in PC12 Cell Membrane Depolarization and Bradykinin Signaling

1997 • 204 citations

Protein Modules and Signaling Networks

2000 • 159 citations

Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets.

1990 • 126 citations

G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.

1995 • 122 citations

Functional coupling of the human dopamine D3 receptor in a transfected NG 108-15 neuroblastoma-glioma hybrid cell line

1994 • 121 citations

Selective Inhibition of Adenylyl Cyclase Type V by the Dopamine D₃Receptor

1997 • 119 citations

Functional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: 1. Activation of postsynaptic D3 receptors mediates hypothermia, whereas blockade of D2 receptors elicits prolactin secretion and catalepsy.

1995 • 118 citations

D2 Dopamine Receptors Stimulate Mitogenesis Through Pertussis Toxin‐Sensitive G Proteins and Ras‐Involved ERK and SAP/JNK Pathways in Rat C6‐D2L Glioma Cells

1998 • 107 citations

Differential Coupling of α1-, α2-, and β-Adrenergic Receptors to Mitogen-activated Protein Kinase Pathways and Differentiation in Transfected PC12 Cells

1998 • 102 citations

Ras-Dependent Activation of Fibroblast Mitogen-Activated Protein Kinase by 5-HT_1A Receptor via a G Protein βγ-Subunit-Initiated Pathway

1996 • 99 citations

G protein activation by human dopamine D3 receptors in high-expressing Chinese hamster ovary cells: A guanosine-5'-O-(3-[35S]thio)- triphosphate binding and antibody study.

1999 • 90 citations

Interaction of Ras with phosphoinositide 3-kinase γ

1997 • 87 citations

Activation of Microtubule‐Associated Protein Kinase (Erk) and p70 S6 Kinase by D₂ Dopamine Receptors

1998 • 79 citations

Tyrosine Kinases of the Src Family Participate in Signaling to MAP Kinase from both Gqand Gi-Coupled Receptors

1998 • 74 citations

Intercellular signal modulation: A pivotal role for protein kinase C

1997 • 65 citations

Activation of Type II Adenylate Cyclase by D₂and D₄but Not D₃Dopamine Receptors

1997 • 60 citations

No Role for Ca⁺⁺or Protein Kinase C inAlpha-1A Adrenergic Receptor Activation of Mitogen-Activated Protein Kinase Pathways in Transfected PC12 Cells

1999 • 36 citations