Differential Coupling of α1-, α2-, and β-Adrenergic Receptors to Mitogen-activated Protein Kinase Pathways and Differentiation in Transfected PC12 Cells

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A

1997 • 1,247 citations

International Union of Pharmacology nomenclature of adrenoceptors.

1994 • 1,173 citations

The Many Faces of G Protein Signaling

1998 • 1,137 citations

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 • 971 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α ₂ -Adrenergic Receptor

1987 • 792 citations

Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

1997 • 671 citations

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

1995 • 541 citations

cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.

1994 • 473 citations

Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors

1997 • 454 citations

Distinct Pathways of Gi- and Gq-mediated Mitogen-activated Protein Kinase Activation

1995 • 451 citations

Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.

1994 • 418 citations

Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells.

1994 • 326 citations

Regulation of the ERK Subgroup of MAP Kinase Cascades Through G Protein-Coupled Receptors

1997 • 323 citations

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

1994 • 322 citations

Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase.

1993 • 241 citations

Differential and synergistic actions of nerve growth factor and cyclic AMP in PC12 cells.

1981 • 239 citations

Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.

1993 • 234 citations

Lysophosphatidic acid stimulates mitogen-activated protein kinase activation via a G-protein-coupled pathway requiring p21ras and p74raf-1.

1993 • 233 citations

The MEKK-JNK Pathway Is Stimulated by α1-Adrenergic Receptor and Ras Activation and Is Associated with in Vitro and in Vivo Cardiac Hypertrophy

1997 • 231 citations

HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy.

1993 • 228 citations

Dual Effect of β-Adrenergic Receptors on Mitogen-activated Protein Kinase

1995 • 223 citations

Rho Is Required for Gαq and α1-Adrenergic Receptor Signaling in Cardiomyocytes

1996 • 220 citations

Transforming G Protein-coupled Receptors Potently Activate JNK (SAPK)

1995 • 211 citations

alpha1-Adrenergic Receptor Subtypes

1994 • 202 citations

Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation.

1994 • 189 citations

Activation of Jun Kinase/Stress-activated Protein Kinase by GTPase-deficient Mutants of Gα12 and Gα13

1995 • 178 citations

Adrenergic receptor stimulation of the mitogen-activated protein kinase cascade and cardiac hypertrophy

1996 • 165 citations

Cloning, Functional Expression and Tissue Distribution of Human cDNA for the α1C-Adrenergic Receptor

1993 • 154 citations

Activation of p38 Mitogen-activated Protein Kinase by Signaling through G Protein-coupled Receptors

1997 • 154 citations

Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase.

1992 • 142 citations

Lysophosphatidic Acid‐Induced Neurite Retraction in PC12 Cells: Neurite‐Protective Effects of Cyclic AMP Signaling

1996 • 137 citations

GTPase-Deficient Gα₁₆ and Gα_q Induce PC12 Cell Differentiation and Persistent Activation of cJun NH₂-Terminal Kinases

1996 • 123 citations

Adrenergic hormones and control of cardiac myocyte growth

1991 • 122 citations

Nerve growth factor and fibroblast growth factor regulate neurite outgrowth and gene expression in PC12 cells via both protein kinase C- and cAMP-independent mechanisms.

1990 • 121 citations

Molecular cloning and expression of the rat beta 1-adrenergic receptor gene.

1990 • 120 citations

α_1D-Adrenergic Receptors and Mitogen-Activated Protein Kinase Mediate Increased Protein Synthesis by Arterial Smooth Muscle

1997 • 104 citations

Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase.

1993 • 101 citations

Signal transduction pathways involving the raf proto-oncogene

1994 • 99 citations

The Tyrosine Kinase Inhibitor, Genistein, Prevents α-Adrenergic-Induced Cardiac Muscle Cell Hypertrophy by Inhibiting Activation of the Ras-MAP Kinase Signaling Pathway

1994 • 85 citations

Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. III. Coupling of alpha 2-adrenergic receptor subtypes in a cell type-specific manner.

1992 • 85 citations

G protein βγ subunit activates Ras, Raf, and MAP kinase in HEK 293 cells

1995 • 56 citations

Analysis by mRNA levels of the expression of six G protein α-subunit genes in mammalian cells and tissues

1991 • 52 citations

Genomic effects of the putative oncogene G alpha s. Chronic transcriptional activation of the c-fos proto-oncogene in endocrine cells.

1994 • 47 citations

Coupling of Epidermal Growth Factor (EGF) with the Antiproliferative Activity of cAMP Induces Neuronal Differentiation

1997 • 46 citations

Second-messenger generation in PC12 cells. Interactions between cyclic AMP and Ca2+ signals

1988 • 38 citations

Comparison of alpha 1-adrenergic receptor subtypes and signal transduction in SK-N-MC and NB41A3 neuronal cell lines.

1993 • 33 citations

C-terminal Mutation of G Protein β Subunit Affects Differentially Extracellular Signal-regulated Kinase and c-Jun N-terminal Kinase Pathways in Human Embryonal Kidney 293 Cells

1997 • 31 citations

Relationship between alpha 2-adrenergic receptor binding sites and the functional receptors inhibiting norepinephrine release in rat cerebral cortex.

1987 • 31 citations

Close reciprocal regulation of beta 1- and beta 2-adrenergic receptors by dexamethasone in C6 glioma cells: effects on catecholamine responsiveness.

1993 • 29 citations

Two Forms of G_O Type G Proteins: Identification and Distribution in Various Rat Tissues and Cloned Cells

1992 • 20 citations

Role of Ca²⁺ in Differentiation Mediated by Nerve Growth Factor and Dibutyryl Cyclic AMP in PC12 Cells

1996 • 16 citations

Oncogenes and protein kinases in neuronal growth-factor action

1993 • 16 citations

A mutant substituting valine for glycine at position 49 of Gsα induces neuronal differentiation of PC12 cells without activation of adenylate cyclase

1993 • 4 citations