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Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Genomic sequencing.

1984 • 8,343 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Supercoil Sequencing: A Fast and Simple Method for Sequencing Plasmid DNA

1985 • 2,505 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system

1981 • 1,991 citations

STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS

1985 • 1,911 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.

1981 • 1,655 citations

A Method for Isolation of Intact, Translationally Active Ribonucleic Acid

1983 • 1,469 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

1986 • 1,424 citations

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1987 • 1,364 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Affinity purification of sequence-specific DNA binding proteins.

1986 • 1,255 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

1989 • 1,046 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences

1985 • 871 citations

Electroporation for the efficient transfection of mammalian cells with DNA

1987 • 856 citations

A cyclic AMP- and phorbol ester-inducible DNA element

1986 • 780 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene

1987 • 760 citations

Expression of genes transferred into monocot and dicot plant cells by electroporation.

1985 • 749 citations

Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.

1988 • 736 citations

RECEPTORS AND PHOSPHOINOSITIDE-GENERATED SECOND MESSENGERS

1985 • 722 citations

Contacts between Escherichia coli RNA polymerase and an early promoter of phage T7.

1980 • 524 citations

Characterization of junD: a new member of the jun proto-oncogene family.

1989 • 492 citations

jun-D: a third member of the jun gene family.

1989 • 469 citations

Tissue-specific enhancer of the human glycoprotein hormone alpha-subunit gene: dependence on cyclic AMP-inducible elements.

1987 • 409 citations

Synergistic action of the glucocorticoid receptor with transcription factors.

1988 • 407 citations

Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain.

1989 • 396 citations

A genetic analysis of extinction: Trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells

1984 • 365 citations

Genomic footprinting reveals cell type-specific DNA binding of ubiquitous factors

1987 • 356 citations

Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction

1989 • 346 citations

Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription.

1988 • 342 citations

In vivo protein–DNA interactions in a glucocorticoid response element require the presence of the hormone

1986 • 328 citations

Cyclic AMP regulation of the human glycoprotein hormone alpha-subunit gene is mediated by an 18-base-pair element.

1987 • 293 citations

A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1.

1988 • 259 citations

Regulation of transcription by cyclic AMP-dependent protein kinase.

1989 • 247 citations

Identification of a region in the human vasoactive intestinal polypeptide gene responsible for regulation by cyclic AMP.

1987 • 236 citations

Multiple sequence elements in the c-fos promoter mediate induction by cAMP.

1989 • 225 citations

A Protein Kinase Inhibitor Gene Reduces Both Basal and Multihormone-stimulated Prolactin Gene Transcription

1989 • 203 citations

Stimulation of in vitro transcription from the SV40 early promoter by the enhancer involves a specific trans-acting factor.

1984 • 199 citations

Repression of c-fos transcription is mediated through p67SRF bound to the SRE.

1989 • 182 citations

Two different factors bind to the alpha-domain of the polyoma virus enhancer, one of which also interacts with the SV40 and c-fos enhancers.

1987 • 179 citations

Identification of basal and cyclic AMP regulatory elements in the promoter of the phosphoenolpyruvate carboxykinase gene.

1988 • 169 citations

A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1

1990 • 154 citations

Camptothecin-induced in vivo topoisomerase I cleavages in the transcriptionally active tyrosine aminotransferase gene

1987 • 150 citations

Contacts between Escherichia coli RNA polymerase and a lac operon promoter.

1978 • 148 citations

Presence of Chicken Tumour Virus in the Sarcoma of the Adult Rat inoculated after Birth with Rous Sarcoma Tissue

1960 • 142 citations

Tissue-specific DNaseI hypersensitive sites in the 5′-flanking sequences of the tryptophan oxygenase and the tyrosine aminotransferase genes.

1984 • 135 citations

Transcription activation of the tyrosine aminotransferase gene by glucocorticoids and cAMP in primary hepatocytes

1987 • 132 citations

Transcriptional activation of the rat liver tyrosine aminotransferase gene by cAMP.

1984 • 125 citations

Characterization of the cAMP responsive elements from the genes for the alpha-subunit of glycoprotein hormones and phosphoenolpyruvate carboxykinase (GTP). Conserved features of nuclear protein binding between tissues and species.

1988 • 121 citations

Phosphorylation-dependent activation of the adenovirus-inducible E2F transcription factor in a cell-free system.

1989 • 107 citations

Rapid and quantitative recovery of DNA fragments from gels by displacement electrophoresis (isotachophoresis)

1984 • 96 citations

Forskolin inducibility and tissue-specific expression of the fibronectin promoter.

1989 • 91 citations

Tissue-specific and steroid-dependent interaction of transcription factors with the oestrogen-inducible apoVLDL II promoter in vivo.

1988 • 86 citations

Plasmids encoding PKI(1–31), a specific inhibitor of cAMP-stimulated gene expression, inhibit the basal transcriptional activity of some but not all cAMP-regulated DNA response elements in JEG-3 cells

1989 • 42 citations

Catalytic subunit of cAMP‐dependent protein kinase is essential for cAMP‐mediated mammalian gene expression

1988 • 41 citations

In vivofootprinting of the estrogen-inducible vitellogenin II gene from chicken

1988 • 34 citations

A novel and rapid method to generate single stranded DNA probes for genomic footprinting

1988 • 23 citations

Evidence for a cAMP-dependent nuclear factor capable of interacting with a specific region of a eukaryotic gene.

1988 • 17 citations

Genomic Footprinting

1988 • 8 citations