Cytokine Prestimulation as a Gene Therapy Strategy: Implications for Using the MDR1 Gene as a Dominant Selectable Marker

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1991 • 962 citations

Neutrophil kinetics in man.

1976 • 545 citations

Selection of Drug-Resistant Bone Marrow Cells in Vivo After Retroviral Transfer of Human MDR 1

1992 • 500 citations

Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation

1995 • 496 citations

Gene marking to determine whether autologous marrow infusion restores long-term haemopoiesis in cancer patients

1993 • 434 citations

Separation of pluripotent haematopoietic stem cells from spleen colony-forming cells

1990 • 414 citations

Functional Isolation and Characterization of Human Hematopoietic Stem Cells

1995 • 414 citations

Transfer and expression of the human multiple drug resistance gene into live mice.

1992 • 210 citations

The effects on hematopoiesis of recombinant stem cell factor (ligand for c-kit) administered in vivo to mice either alone or in combination with granulocyte colony-stimulating factor

1991 • 169 citations

Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow.

1987 • 144 citations

Serial transplantation of methotrexate-resistant bone marrow: protection of murine recipients from drug toxicity by progeny of transduced stem cells

1990 • 141 citations

Steel factor influences the distribution and activity of murine hematopoietic stem cells in vivo.

1993 • 137 citations

Bone marrow collected 14 days after in vivo administration of granulocyte colony-stimulating factor and stem cell factor to mice has 10-fold more repopulating ability than untreated bone marrow

1996 • 127 citations

In vivo administration of stem cell factor to mice increases the absolute number of pluripotent hematopoietic stem cells

1993 • 121 citations

Bone marrow collected 14 days after in vivo administration of granulocyte colony-stimulating factor and stem cell factor to mice has 10-fold more repopulating ability than untreated bone marrow

1996 • 119 citations

A gene transfer strategy for making bone marrow cells resistant to trimetrexate

1996 • 106 citations

A c-kit ligand, recombinant human stem cell factor, mediates reversible expansion of multiple CD34+ colony-forming cell types in blood and marrow of baboons

1992 • 90 citations

Granulocytopoiesis

1964 • 89 citations

Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector.

1994 • 88 citations

Resistance to taxol chemotherapy produced in mouse marrow cells by safety-modified retroviruses containing a human MDR-1 transcription unit.

1995 • 82 citations

DNA-mediated transfer and cloning of a human multidrug-resistant gene of adriamycin-resistant myelogenous leukemia K562.

1987 • 70 citations

Total marrow failure induced by pegylated stem-cell factor administered before 5-fluorouracil

1994 • 47 citations

Splenic primitive hematopoietic stem cell (PHSC) activity is enhanced by steel factor because of PHSC proliferation

1994 • 27 citations

Different recovery patterns of mouse haemopoietic stem cells in response to cytotoxic agents

1976 • 10 citations

Hematopoietic Precursor Cells in Mice Treated With 4-Demethoxydaunorubicin and Doxorubicin<xref ref-type="fn" rid="FN2">2</xref>

1982 • 7 citations