Soluble cytokine receptors

Growth hormone receptor and serum binding protein: purification, cloning and expression

1987 • 1,540 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro.

1985 • 1,143 citations

Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

1994 • 1,120 citations

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

1994 • 1,066 citations

The IL-6 Signal Transducer, gp130: an Pncostatin M Receptor and Affinity Converter for the LIF Receptor

1992 • 897 citations

Interleukin-6 and Its Receptor: A Paradigm for Cytokines

1992 • 889 citations

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

1991 • 861 citations

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.

1992 • 842 citations

Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors.

1992 • 832 citations

The kit ligand: A cell surface molecule altered in steel mutant fibroblasts

1990 • 777 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone.

1989 • 726 citations

Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

1995 • 713 citations

CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130

1992 • 693 citations

Interleukin-1 Receptor Antagonist

1993 • 670 citations

The human interferon $alpha;/$beta; receptor: Characterization and molecular cloning

1994 • 658 citations

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

1990 • 650 citations

The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms

1989 • 645 citations

Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily

1990 • 614 citations

The Receptor for Ciliary Neurotrophic Factor

1991 • 604 citations

Molecular physiology of granulocyte-macrophage colony-stimulating factor

1991 • 598 citations

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

1991 • 598 citations

Interleukin-6 in human multiple myeloma

1995 • 550 citations

The soluble interleukin‐6 receptor is generated by shedding

1993 • 502 citations

Mouse interleukin‐12 (IL‐12) p40 homodimer: a potent IL‐12 antagonist

1995 • 441 citations

A Specific Growth Hormone-Binding Protein in Human Plasma: Initial Characterization*

1986 • 424 citations

Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity.

1995 • 407 citations

The growth hormone-binding protein in rat serum is an alternatively spliced form of the rat growth hormone receptor.

1989 • 399 citations

Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing.

1995 • 398 citations

Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor

1992 • 388 citations

Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia.

1992 • 383 citations

Serum Transferrin Receptor

1993 • 378 citations

Identification and characterization of specific binding proteins for growth hormone in normal human sera.

1986 • 313 citations

Soluble receptors for tumour necrosis factor in clinical laboratory diagnosis

1995 • 296 citations

A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor.

1990 • 292 citations

Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice

1994 • 287 citations

The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site.

1994 • 275 citations

Soluble IL-2 receptor in rheumatoid arthritis. Correlation with disease activity, IL-1 and IL-2 inhibition.

1988 • 274 citations

Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids.

1994 • 238 citations

Release of soluble receptors for tumor necrosis factor (TNF) in relation to circulating TNF during experimental endotoxinemia.

1992 • 238 citations

Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms.

1989 • 228 citations

Molecular cloning and expression of the murine interleukin-5 receptor.

1990 • 227 citations

Increased and highly stable levels of functional soluble interleukin‐6 receptor in sera of patients with monoclonal gammopathy

1993 • 206 citations

Imbalance between tumour necrosis factor-alpha and soluble TNF receptor concentrations in severe meningococcaemia. The J5 Study Group.

1992 • 203 citations

A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue.

1990 • 198 citations

Soluble interleukin‐6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism

1994 • 197 citations

Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis.

1994 • 188 citations

Purification and characterization of the receptor for murine granulocyte colony-stimulating factor.

1990 • 180 citations

TNF induces internalization of the p60 receptor and shedding of the p80 receptor.

1994 • 175 citations

Structure-function relationships for the IL 2-receptor system. IV. Analysis of the sequence and ligand-binding properties of soluble Tac protein.

1987 • 165 citations

A Truncated Erythropoietin Receptor That Fails to Prevent Programmed Cell Death of Erythroid Cells

1992 • 156 citations

Expression cloning of the murine and human interleukin 9 receptor cDNAs.

1992 • 155 citations

A major binding protein for leukemia inhibitory factor in normal mouse serum: identification as a soluble form of the cellular receptor.

1992 • 146 citations

Evidence for generation of the growth hormone-binding protein through proteolysis of the growth hormone membrane receptor.

1993 • 142 citations

Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit.

1992 • 140 citations

Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth.

1993 • 134 citations

Increased soluble interleukin‐2 receptor concentrations in suicide attempters

1993 • 132 citations

Inhibition of Tyrosine Kinase Activity of the Epidermal Growth Factor (EGF) Receptor by a Truncated Receptor Form That Binds to EGF: Role for Interreceptor Interaction in Kinase Regulation

1989 • 125 citations

Significance of soluble interleukin-2 receptor levels for evaluation of the progression of adult T-cell leukemia

1994 • 123 citations

Differential shedding of the two subunits of the interleukin‐6 receptor

1993 • 120 citations

Levels of T-lymphocyte subpopulations, interleukin-1β, and soluble interleukin-2 receptor in acute myocardial infarction

1994 • 119 citations

Cloning of the low-affinity murine granulocyte-macrophage colony-stimulating factor receptor and reconstitution of a high-affinity receptor complex.

1992 • 117 citations

Soluble interleukin-2 receptors in the sera of patients with hairy cell leukemia: relationship with the effect of recombinant alpha-interferon therapy on clinical parameters and natural killer in vitro activity

1987 • 111 citations

Regulation of alloreactivity in vivo by IL-4 and the soluble IL-4 receptor.

1991 • 109 citations

Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor.

1991 • 108 citations

Tumor necrosis factor induces a selective shedding of its p75 receptor from human neutrophils.

1994 • 105 citations

Cloning and structural analysis of the human c-kit gene.

1992 • 105 citations

Evidence that natural murine soluble interleukin 4 receptors may act as transport proteins.

1991 • 99 citations

Identification of soluble forms of the fibroblast growth factor receptor in blood.

1994 • 97 citations

Persistently elevated soluble tumor necrosis factor receptor and interleukin-1 receptor antagonist levels in critically ill patients.

1994 • 94 citations

Proinflammatory cytokines in acute asthma

1991 • 91 citations

Elevated serum levels of soluble tumour necrosis factor receptors (sTNF-R) in patients with HIV infection

1992 • 84 citations

Increased plasma concentrations of soluble tumor necrosis factor receptors in sepsis syndrome

1994 • 81 citations

Soluble hormone receptors [editorial; comment]

1993 • 78 citations

Mechanism of release of soluble forms of tumor necrosis factor/lymphotoxin receptors by phorbol myristate acetate-stimulated human THP-1 cells in vitro.

1993 • 77 citations

Specific binding of interleukin 1 (IL-1)β and IL-1 receptor antagonist (IL-1ra) to human serum. High-affinity binding of IL-1ra to soluble IL-1 receptor type I

1993 • 76 citations

In vivo kinetics of a covalent growth hormone-binding protein complex

1989 • 76 citations

Low-affinity placenta-derived receptors for human granulocyte-macrophage colony-stimulating factor can deliver a proliferative signal to murine hemopoietic cells.

1990 • 75 citations

Soluble kit receptor in human serum

1995 • 73 citations

Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130

1992 • 66 citations

Adherence of neutrophils induces release of soluble tumor necrosis factor receptor forms.

1994 • 64 citations

Cloning of a potentially soluble receptor for human GM-CSF

1990 • 64 citations

The Stem Cell

1991 • 63 citations

The alpha subunit of the human granulocyte-macrophage colony-stimulating factor receptor signals for glucose transport via a phosphorylation-independent pathway.

1994 • 60 citations

Identification and characterization of a low-affinity granulocyte- macrophage colony-stimulating factor receptor on primary and cultured human melanoma cells

1991 • 59 citations

Origin of a soluble truncated transferrin receptor

1993 • 59 citations

Identification and cellular distribution of distinct proteins forming human GM-CSF receptor.

1990 • 56 citations

Soluble tumor necrosis factor receptor: inhibition of human immunodeficiency virus activation.

1993 • 54 citations

Low serum interleukin-2 receptor levels correlate with a good prognosis in patients with Hodgkin's lymphoma

1991 • 51 citations

High serum and ascitic soluble interleukin-2 receptor alpha levels in advanced epithelial ovarian cancer [see comments]

1993 • 51 citations

A soluble form of the interleukin‐1 receptor produced by a human B cell line

1990 • 50 citations

Identification of a soluble receptor for platelet-derived growth factor in cell-conditioned medium and human plasma

1993 • 49 citations

Production of soluble IL-4 receptors by murine spleen cells is regulated by T cell activation and IL-4.

1993 • 44 citations

Elevation of soluble IL-2 receptor and IL-4, and nonelevation of IFN-gamma in sera from patients with allergic asthma.

1993 • 43 citations

Monoclonal Antibodies to the Soluble Human IL-6 Receptor: Affinity Purification, ELISA, and Inhibition of Ligand Binding

1991 • 42 citations

In vitro characterization of the human recombinant soluble granulocyte- macrophage colony-stimulating factor receptor

1995 • 40 citations

Granulocyte-macrophage colony-stimulating factor signals for increased glucose uptake in human melanoma cells

1995 • 37 citations

Delayed allograft rejection in mice transgenic for a soluble form of the IL-4 receptor

1992 • 36 citations

High serum and ascitic soluble interleukin-2 receptor alpha levels in advanced epithelial ovarian cancer [see comments]

1993 • 36 citations

Evidence for endocytosis-dependent proteolysis in the generation of soluble truncated nerve growth factor receptors by A875 human melanoma cells

1991 • 36 citations

Identification of a distinct low-affinity receptor for human interleukin-4 on pre-B cells

1993 • 35 citations

Membrane-associated and soluble granulocyte/macrophage-colony-stimulating factor receptor alpha subunits are independently regulated in HL-60 cells.

1995 • 33 citations

Mechanisms involved in the processing of the p55 and the p75 tumor necrosis factor (TNF) receptors to soluble receptor forms.

1994 • 33 citations

Organization and chromosomal localization of the human interleukin 5 receptor alpha-chain gene.

1992 • 33 citations

Pregnancy associated increase in mRNA for soluble D‐factor/LIF receptor in mouse liver

1993 • 32 citations

Serum levels of soluble interleukin‐2 receptor in hairy cell leukaemia: a reliable marker of neoplastic bulk

1989 • 31 citations

Characterization of the soluble human granulocyte-macrophage colony-stimulating factor receptor complex.

1991 • 30 citations

Isolation of a cDNA encoding a potential soluble receptor for human erythropoietin

1991 • 30 citations

Generation of the truncated form of the nerve growth factor receptor by rat Schwann cells. Evidence for post-translational processing.

1991 • 29 citations

Native avian c-erbB gene expresses a secreted protein product corresponding to the ligand-binding domain of the receptor.

1991 • 28 citations

Serum soluble interleukin-2 (IL-2) receptor levels in women with breast carcinoma and its correlation with IL-2 receptor expression on blood lymphocytes and lymphocytic infiltration within the tumour

1991 • 25 citations

Molecular cloning of a soluble form of the granulocyte‐‐macrophage colony‐stimulating factor receptor α chain from a myelomonocytic cell line. expression, biologic activity, and preliminary analysis of transcript distribution

1994 • 24 citations

Effects of therapy with soluble tumour necrosis factor receptor fusion protein on pulmonary cytokine expression and lung injury following haemorrhage and resuscitation

1994 • 19 citations

Expression of interleukin-2 receptor alpha (IL-2R alpha) mRNA and protein in advanced epithelial ovarian cancer.

1994 • 18 citations

Alternatively spliced mRNAs encoding soluble isoforms of the erythropoietin receptor in murine cell lines and bone marrow

1994 • 16 citations

Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor

1994 • 16 citations

High Complete Remission Rate in Hairy Cell Leukemia Treated with 2-Chlorodeoxyadenosine

1993 • 15 citations

Follow-up of soluble interleukin-2 receptor levels after thymectomy in patients with myasthenia gravis

1992 • 14 citations

Serum Levels of CD8 Antigen and Soluble Interleukin 2 Receptors in Patients with B Cell Chronic Lymphocytic Leukemia

1991 • 13 citations

Serial measurement of soluble interleukin 2 receptor levels: an early indicator of treatment response for Lyme disease.

1993 • 10 citations

Effects of soluble interleukin‐1 receptor and tumor‐necrosis factor receptor, respectively, on the IL‐1‐ and TNF‐α‐induced DNA synthesis of acute myeloblastic leukemia blasts in vitro

1994 • 8 citations