Role of excitatory amino acid neurotransmission in synaptic plasticity and pathology. An integrative hypothesis concerning the pathogenesis and evolutionary advantages of schizophrenia-related genes

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects

1968 • 4,041 citations

Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

1984 • 2,822 citations

Synaptic density in human frontal cortex — Developmental changes and effects of aging

1979 • 2,587 citations

Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.

1979 • 1,970 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

1983 • 1,400 citations

Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?

1982 • 1,352 citations

NMDA receptors - their role in long-term potentiation

1987 • 1,177 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path

1973 • 1,140 citations

Concurrent Overproduction of Synapses in Diverse Regions of the Primate Cerebral Cortex

1986 • 1,126 citations

The Biochemistry of Memory: A New and Specific Hypothesis

1984 • 1,048 citations

Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation

1986 • 1,037 citations

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

1986 • 979 citations

Positron Emission Tomography Reveals Elevated D ₂ Dopamine Receptors in Drug-Naive Schizophrenics

1986 • 935 citations

Blockade of "NMDA" Receptors Disrupts Experience-Dependent Plasticity of Kitten Striate Cortex

1987 • 920 citations

Basal Ganglia and Limbic System Pathology in Schizophrenia

1985 • 891 citations

Synaptogenesis in human visual cortex — evidence for synapse elimination during normal development

1982 • 747 citations

Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia

1980 • 703 citations

Induction of Synaptic Potentiation in Hippocampus by Patterned Stimulation Involves Two Events

1986 • 603 citations

A neurohistological correlate of schizophrenia.

1984 • 584 citations

N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes.

1987 • 529 citations

Long-term potentiation of the perforant path-granule cell synapse in the rat hippocampus

1975 • 501 citations

Neuropathology of Schizophrenia

1982 • 472 citations

NMDA receptors in the visual cortex of young kittens are more effective than those of adult cats

1987 • 446 citations

Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptors.

1986 • 399 citations

Stable hippocampal long-term potentiation elicited by ‘theta’ pattern stimulation

1987 • 345 citations

Annual progress in child psychiatry and child development

1973 • 239 citations

Changes in voltage dependence of NMDA currents during development

1988 • 231 citations

Excitatory and inhibitory neurotransmitters in the generation and degeneration of hippocampal neuroarchitecture

1989 • 230 citations

Ketamine—xylazine anaesthesia blocks consolidation of ocular dominance changes in kitten visual cortex

1987 • 206 citations

Identification of fodrin as a major calmodulin-binding protein in postsynaptic density preparations.

1983 • 205 citations

Micromolar Calcium Stimulates Proteolysis and Glutamate Binding in Rat Brain Synaptic Membranes

1981 • 180 citations

Excitatory amino acids inhibit stimulation of phosphatidylinositol metabolism by aminergic agonists in hippocampus

1986 • 162 citations

Stimulation of NMDA receptors induces proteolysis of spectrin in hippocampus

1988 • 147 citations

On long‐lasting potentiation in the hippocampus. a proposed mechanism for its dependence on coincident pre‐ and postsynaptic activity

1985 • 136 citations

Regulation of glutamate receptor binding by the cytoskeletal protein fodrin

1985 • 116 citations

Effects of high-frequency synaptic stimulation on glumate receptor binding studied with a modified in vitro hippocampal slice preparation

1982 • 115 citations

What maintains the frequencies of human genetic diseases?

1987 • 108 citations

Chronic administration of a thiol-proteinase inhibitor blocks long-term potentiation of synaptic responses

1988 • 93 citations

Calmodulin stimulates the degradation of brain spectrin by calpain

1987 • 89 citations

Calcium dependent aspects of synaptic plasticity, excitatory amino acid neurotransmission, brain aging and schizophrenia: A unifying hypothesis

1987 • 82 citations

Splitting schizophrenia

1988 • 76 citations

Possible Changes in Striatal and Limbic Cholinergic Systems in Schizophrenia

1977 • 70 citations

A Clinical Evaluation of Children with Psychotic Parents

1969 • 64 citations

The 12th J. A. F. Stevenson Memorial Lecture: Aging, Alzheimer's disease, and the cholinergic system

1984 • 62 citations

Tardive dyskinesia and depressive illness.

1976 • 58 citations

Tardive dyskinesia and the primary psychiatric diagnosis

1984 • 57 citations

Use of cystine to distinguish glutamate binding from glutamate sequestration

1987 • 52 citations

The Psychology of Men of Genius. By Ernst Kretschmer. (London: Kegan Paul, Trench, Trübner & Co. Ltd.1931.

1932 • 47 citations

The problem of genius

1931 • 41 citations

Annual Progress in Child Psychiatry and Child Development

1970 • 35 citations

Participation of cystein proteinase in the high affinity ca2+-dependent binding of glutamate to hippocampal synaptic membranes

1980 • 33 citations

Family Transmission of Schizophrenia: A Review and Synthesis

1982 • 26 citations

An Icelandic Family Study of Schizophrenia

1973 • 21 citations

Molecular pharmacology: Structure and function of acetyl-choline-receptor ion channels

1986 • 4 citations