Effector functions of activated macrophages against parasites

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Macrophage deactivation by interleukin 10.

1991 • 1,253 citations

IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.

1992 • 709 citations

Mammalian Nitric Oxide Synthases

1992 • 514 citations

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

1992 • 494 citations

Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha.

1990 • 453 citations

Transforming Growth Factor-β in Leishmanial Infection: a Parasite Escape Mechanism

1992 • 439 citations

The microbicidal activity of interferon‐γ‐treated macrophages against Trypanosoma cruzi involves an L‐arginine‐dependent, nitrogen oxide‐mediated mechanism inhibitable by interleukin‐10 and transforming growth factor‐β

1992 • 437 citations

Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin.

1992 • 428 citations

Tumour necrosis factor α restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice

1992 • 424 citations

IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity.

1992 • 422 citations

Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages

1992 • 384 citations

Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection.

1992 • 364 citations

Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation.

1992 • 352 citations

Impairment of macrophage functions after ingestion of Plasmodium falciparum-infected erythrocytes or isolated malarial pigment.

1992 • 314 citations

Killing of Plasmodium falciparum in vitro by nitric oxide derivatives

1991 • 311 citations

IFN-gamma-induced L-arginine-dependent toxoplasmastatic activity in murine peritoneal macrophages is mediated by endogenous tumor necrosis factor-alpha.

1992 • 285 citations

Tumor necrosis factor-alpha triggers antitoxoplasmal activity of IFN-gamma primed macrophages.

1991 • 197 citations

L-Arginine-Dependent Reactive Nitrogen Intermediates and the Antimicrobial Effect of Activated Human Mononuclear Phagocytes

1992 • 182 citations

Differential susceptibility of activated macrophage cytotoxic effector reactions to the suppressive effects of transforming growth factor-beta 1.

1991 • 147 citations

Macrophage cytotoxicity against Entamoeba histolytica trophozoites is mediated by nitric oxide from L-arginine.

1992 • 143 citations

Nitric oxide mediates suppression of T cell responses in murine Trypanosoma brucei infection

1992 • 136 citations

In vivo induction of nitrite and nitrate by tumor necrosis factor, lymphotoxin, and interleukin-1: possible roles in malaria

1992 • 129 citations

Macrophage-Pathogen Interactions

1993 • 121 citations

IL-4 suppresses cytokine gene expression induced by IFN-gamma and/or IL-2 in murine peritoneal macrophages.

1992 • 110 citations

Immunity to helminths: Ready to tip the biochemical balance?

1992 • 89 citations

Leishmania donovani infection in scid mice: lack of tissue response and in vivo macrophage activation correlates with failure to trigger natural killer cell-derived gamma interferon production in vitro

1992 • 79 citations

IL-4 inhibits macrophage-mediated killing of Plasmodium falciparum in vitro. A possible parasite-immune evasion mechanism.

1992 • 77 citations

Polymorphisms in the tumor necrosis factor alpha (TNF-alpha) gene correlate with murine resistance to development of toxoplasmic encephalitis and with levels of TNF-alpha mRNA in infected brain tissue.

1992 • 72 citations

Strategies of obligate intracellular parasites for evading host defences

1991 • 72 citations

T-cell-mediated activation of macrophages

1991 • 71 citations

Interleukin-4 Inhibits Human Macrophage Activation by Tumor Necrosis Factor, Granulocyte-Monocyte Colony-Stimulating Factor, and Interleukin-3 for Antileishmanial Activity and Oxidative Burst Capacity

1992 • 66 citations

Phagocytosis of Leishmania enhances macrophage activation by IFN-gamma and lipopolysaccharide.

1991 • 56 citations

Catalase inhibits nitric oxide synthesis and the killing of intracellular Leishmania major in murine macrophages

1992 • 53 citations

Modulation of tumor necrosis factor production by macrophages in Entamoeba histolytica infection

1992 • 51 citations

Soluble TNF and membrane TNF expressed on CD4+ T lymphocytes differ In their ability to activate macrophage antileishmanial defense

1992 • 50 citations

Gamma interferon-activated human macrophages and Toxoplasma gondii, Chlamydia psittaci, and Leishmania donovani: antimicrobial role of limiting intracellular iron

1991 • 49 citations

Feedback suppression of staphylococcal enterotoxin-stimulated T-lymphocyte proliferation by macrophages through inductive nitric oxide synthesis

1992 • 37 citations

Schistosoma mansoni: Cloning of a complementary DMA encoding a cytosolic superoxide dismutase and high-yield expression of the enzymatically active gene product in Escherichia coli

1992 • 37 citations

Granulocyte-macrophage colony-stimulating factor increases the infectivity of Leishmania amazonensis by protecting promastigotes from heat-induced death

1992 • 36 citations

The arginine-dependent cytolytic mechanism plays a role in destruction of Naegleria fowleri amoebae by activated macrophages

1992 • 35 citations

Nitrite Production by Activated Murine Macrophages Correlates with Their Toxoplasmastatic Activity, Ia Antigen Expression, and Production of H2O2

1991 • 31 citations

Interleukin-3 induces antimicrobial activity against Leishmania amazonensis and Trypanosoma cruzi and tumoricidal activity in human peripheral blood-derived macrophages

1992 • 31 citations

Cytotoxic activity and production of toxic nitrogen oxides by macrophages treated with IFN-gamma and monoclonal antibodies against the 73-kDa lipopolysaccharide receptor.

1992 • 30 citations

Activated mouse macrophages kill Entamoeba histoloytica trophozoites by releasing reactive nitrogen intermediates

1992 • 15 citations

Macrophage activation for intracellular killing as induced by a Ca2+ ionophore. Dependence on <scp>l</scp>-arginine-derived nitrogen oxidation products

1992 • 13 citations

Immune effector role of macrophages in experimental schistosomiasis mansoni.

1994 • 11 citations

Essential role of tumor necrosis factor and other cytokines in the pathogenesis of cerebral malaria: experimental and clinical studies.

1992 • 11 citations

Mechanisms of resistance to Leishmania aethiopica. I. Interferon‐γ in combination with a cytokine (not tumor necrosis factor‐α) is required, but cannot act alone in the inhibition of intracellular forms of L. aethiopica in THP1 cells

1992 • 8 citations

Induction of tumor necrosis factor α by Leishmania infantum in murine macrophages from different inbred mice strains

1992 • 8 citations

Recombinant human granulocyte macrophage colony-stimulating factor (rhGM-CSF) induces human macrophage production of transforming growth factor-alpha.

1991 • 6 citations