Immunophenotypic findings in acute myeloid leukemia with FLT3 internal tandem duplication.

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Proposed Revised Criteria for the Classification of Acute Myeloid Leukemia

1985 • 2,981 citations

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

2002 • 1,700 citations

Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)

2002 • 1,599 citations

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials

2001 • 1,531 citations

Internal tandem duplication of the flt3 gene found in acute myeloid leukemia.

1996 • 1,158 citations

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

2001 • 1,148 citations

Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

2002 • 983 citations

Report of the National Cancer Institute-sponsored workshop on definitions of diagnosis and response in acute myeloid leukemia.

1990 • 813 citations

Prognostic Implication of FLT3 and N- RAS Gene Mutations in Acute Myeloid Leukemia

1999 • 773 citations

Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study.

2001 • 634 citations

Molecular cloning of a ligand for the flt3flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells

1993 • 546 citations

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

2002 • 501 citations

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

1997 • 462 citations

STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.

1994 • 459 citations

Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs

1994 • 453 citations

FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia

2001 • 425 citations

Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia

1997 • 344 citations

PML/RARα and FLT3-ITD induce an APL-like disease in a mouse model

2002 • 321 citations

Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene

2000 • 284 citations

Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain

2002 • 280 citations

Immunophenotyping Investigation of Minimal Residual Disease Is a Useful Approach for Predicting Relapse in Acute Myeloid Leukemia Patients

1997 • 271 citations

Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells.

1996 • 259 citations

Hematopoietic growth factors and their receptors in acute leukemia

1993 • 215 citations

Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia

1997 • 207 citations

Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation

2000 • 201 citations

Incidence and prognostic value of FLT3 internal tandem duplication and D835 mutations in acute myeloid leukemia.

2003 • 175 citations

Flt3 ligand stimulates/costimulates the growth of myeloid stem/progenitor cells.

1995 • 168 citations

FLT3 receptor expression on the surface of normal and malignant human hematopoietic cells

1996 • 150 citations

Flt3 ligand stimulates proliferation and inhibits apoptosis of acute myeloid leukemia cells: regulation of Bcl-2 and Bax

1996 • 145 citations

Oncogenic tyrosine kinases and the dna-damage response

2002 • 134 citations

Expression of FLT3 receptor and FLT3-ligand in human leukemia-lymphoma cell lines.

1995 • 118 citations

Genomic structure of the downstream part of the human FLT3 gene: exon/intron structure conservation among genes encoding receptor tyrosine kinases (RTK) of subclass III

1994 • 113 citations

Acute myeloid leukemia with MLL rearrangements: clinicobiological features, prognostic impact and value of flow cytometry in the detection of residual leukemic cells

2003 • 107 citations

Effects of FLT3 ligand on human leukemia cells. I. Proliferative response of myeloid leukemia cells.

1996 • 44 citations

Effects of FLT3 ligand on human leukemia cells. II. Agonistic and antagonistic effects of other cytokines.

1996 • 20 citations

An abnormal CD34+myeloid/CD34+lymphoid ratio at the end of chemotherapy predicts relapse in patients with acute myeloid leukemia

1999 • 13 citations