Acute myeloid leukemia with MLL rearrangements: clinicobiological features, prognostic impact and value of flow cytometry in the detection of residual leukemic cells

Proposed Revised Criteria for the Classification of Acute Myeloid Leukemia

1985 • 2,981 citations

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1995 • 1,374 citations

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1990 • 813 citations

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

1991 • 602 citations

Proposals for immunological classification of acute leukemias.

1995 • 543 citations

Screening for MLL tandem duplication in 387 unselected patients with AML identify a prognostically unfavorable subset of AML

2000 • 292 citations

Immunophenotyping Investigation of Minimal Residual Disease Is a Useful Approach for Predicting Relapse in Acute Myeloid Leukemia Patients

1997 • 271 citations

Clinical significance of cytogenetics in acute myeloid leukemia.

1997 • 267 citations

MLL rearrangements in haematological malignancies: lessons from clinical and biological studies

1999 • 266 citations

Rearrangement of ALL1 (MLL) in acute myeloid leukemia with normal cytogenetics.

1998 • 234 citations

Molecular basis of IIq23 rearrangements in hematopoietic malignant proliferations

1995 • 211 citations

11q23 rearrangements in acute leukemia.

1996 • 197 citations

Adult Patients With De Novo Acute Myeloid Leukemia and t(9; 11)(p22; q23) Have a Superior Outcome to Patients With Other Translocations Involving Band 11q23: A Cancer and Leukemia Group B Study

1997 • 184 citations

Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes.

1994 • 168 citations

The flow cytometric pattern of CD34, CD15 and CD13 expression in acute myeloblastic leukemia is highly characteristic of the presence of PML-RARalpha gene rearrangements.

1999 • 126 citations

Hematological malignancies with t(9;11)(p21–22;q23) – a laboratory and clinical study of 125 cases

1998 • 114 citations

Partial Tandem Duplications of the MLL Gene Are Detectable in Peripheral Blood and Bone Marrow of Nearly All Healthy Donors

1998 • 112 citations

Adult precursor B-ALL with BCR/ABL gene rearrangements displays a unique immunophenotype based on the pattern of CD10, CD34, CD13 and CD38 expression

2001 • 111 citations

Rearrangements involving chromosome band 11Q23 in acute leukaemia.

1993 • 108 citations

Incidence and characterization of MLL gene (11q23) rearrangements in acute myeloid leukemia M1 and M5

1996 • 103 citations

Surface antigen phenotype can predict TEL-AML1 rearrangement in childhood B-precursor ALL: a Pediatric Oncology Group study

1998 • 86 citations

Acute myeloid leukemia with 11q23 translocations: myelomonocytic immunophenotype by multiparameter flow cytometry

1998 • 80 citations

ALL1 gene alterations in acute leukemia: biological and clinical aspects.

1998 • 57 citations

ALL-1 gene rearrangements in acute myeloid leukemia: association with M4-M5 French-American-British classification subtypes and young age.

1995 • 53 citations

A prospective study of residual-disease monitoring of theALL1/AF4 transcript in patients with t(4;11) acute lymphoblastic leukemia

2000 • 47 citations

Monitoring of minimal residual leukemia in patients with MLL-AF9 positive acute myeloid leukemia by RT-PCR

1999 • 45 citations

Southern blot analysis of ALL-1 rearrangements at chromosome 11q23 in acute leukemia.

1993 • 31 citations

Minimal residual disease in acute monocytic leukemia patient with trisomy 11 and partial tandem duplication of MLL

1997 • 13 citations

Characterization of acute myeloid leukemia with MLL rearrangements – no increase in the incidence of coexpression of lymphoid-associated antigens on leukemic blasts

2000 • 13 citations

An abnormal CD34+myeloid/CD34+lymphoid ratio at the end of chemotherapy predicts relapse in patients with acute myeloid leukemia

1999 • 13 citations

MLL Cleavage Occurs in Approximately 5% of De Novo Acute Myeloid Leukemia, Including in Patients Analyzed Before Treatment Induction

1997 • 7 citations