IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils

Interleukin-13: Central Mediator of Allergic Asthma

1998 • 2,642 citations

Requirement for IL-13 Independently of IL-4 in Experimental Asthma

1998 • 1,869 citations

Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells

1981 • 669 citations

Epidermal growth factor system regulates mucin production in airways

1999 • 573 citations

Marked Goblet Cell Hyperplasia with Mucus Accumulation in the Airways of Patients Who Died of Severe Acute Asthma Attack

1992 • 513 citations

Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production

1997 • 464 citations

Signal Transducer and Activator of Transcription Factor 6 (Stat6)-deficient Mice Are Protected from Antigen-induced Airway Hyperresponsiveness and Mucus Production

1998 • 458 citations

IL-4 Induces Mucin Gene Expression and Goblet Cell Metaplasia In Vitro and In Vivo

1999 • 453 citations

Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity.

1996 • 355 citations

Oxidative Stress Causes Mucin Synthesis Via Transactivation of Epidermal Growth Factor Receptor: Role of Neutrophils

2000 • 344 citations

Interleukin‐8 as a mediator of sympathetic pain

1991 • 333 citations

Interleukin-4 and lnterleukin-13: Their Similarities and Discrepancies

1998 • 324 citations

Quantitative Structural Analysis of Peripheral Airways and Arteries in Sudden Fatal Asthma

1991 • 321 citations

Interleukin-8: an important chemoattractant in sputum of patients with chronic inflammatory airway diseases

1993 • 315 citations

A novel role for murine IL-4 in vivo: induction of MUC5AC gene expression and mucin hypersecretion.

1997 • 263 citations

Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils.

1999 • 244 citations

Expression of Epidermal Growth Factor and Epidermal Growth Factor Receptor Immunoreactivity in the Asthmatic Human Airway

1998 • 218 citations

Lung inflammation and epithelial changes in a murine model of atopic asthma.

1996 • 208 citations

Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice

1997 • 205 citations

Th2-Induced Airway Mucus Production Is Dependent on IL-4Rα, But Not on Eosinophils

1999 • 192 citations

Inhibition of lung inflammatory reactions in rats by an anti-human IL-8 antibody.

1993 • 183 citations

EGF-Receptor Phosphorylation and Signaling Are Targeted by H₂O₂ Redox Stress

1998 • 183 citations

Human Lung Mast Cells and Pulmonary Macrophages Produce Tumor Necrosis Factor-α in Sensitized Lung Tissue after IgE Receptor Triggering

1992 • 153 citations

TNF-alpha production by eosinophils in upper airways inflammation (nasal polyposis).

1994 • 129 citations

TNF α is localized to nasal mucosal mast cells and is released in acute allergic rhinitis

1995 • 128 citations

Death in Asthmatics

1959 • 110 citations

Polymorphonuclear leukocytes as a significant source of tumor necrosis factor-alpha in endotoxin-challenged lung tissue.

1993 • 104 citations

Tumor necrosis factor alpha induces the expression of transforming growth factor alpha and the epidermal growth factor receptor in human pancreatic cancer cells.

1993 • 103 citations

Oxidative Stress Activates the Human Histidine Decarboxylase Promoter in AGS Gastric Cancer Cells

1998 • 63 citations

Agarose plug instillation causes goblet cell metaplasia by activating EGF receptors in rat airways

2000 • 49 citations

Endogenous PMN-derived reactive oxygen intermediates provide feedback regulation on respiratory burst signal transduction

1997 • 27 citations

‘Is MDMA a Human Neurotoxin?’:Diverse Views from the Discussants

2000 • 26 citations

Cell-Degeneration Pattern in Bone Marrow and Blood of Guinea Pigs Following Administration of Cyclophosphamide

1969 • 5 citations