Perspectives on using nonhuman primates to understand the etiology and treatment of postmenopausal osteoporosis.

Skeletal Tissue Mechanics

2015 • 1,156 citations

Bone Gain in Young Adult Women

1992 • 801 citations

Caloric Intake and Aging

1997 • 736 citations

Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α

2000 • 666 citations

Estrogen Stimulates Gene Expression and Protein Production of Osteoprotegerin in Human Osteoblastic Cells*

1999 • 657 citations

Increased intracortical remodeling following fatigue damage

1993 • 555 citations

Effect of Dietary Protein on Bone Loss in Elderly Men and Women: The Framingham Osteoporosis Study

2000 • 538 citations

Evolution of Human Walking

1988 • 489 citations

Transport mechanism operating between blood supply and osteocytes in long bones

1977 • 441 citations

The mechanisms of estrogen regulation of bone resorption

2000 • 428 citations

Structural Trends in the Aging Femoral Neck and Proximal Shaft: Analysis of the Third National Health and Nutrition Examination Survey Dual-Energy X-Ray Absorptiometry Data

2000 • 411 citations

The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates.

1993 • 402 citations

The Death of Osteocytes via Apoptosis Accompanies Estrogen Withdrawal in Human Bone*

1997 • 386 citations

Behavior and physiology of social stress and depression in female cynomolgus monkeys

1997 • 336 citations

Toward a unifying theory of bone remodeling

2000 • 328 citations

Osteoprotegerin and its Ligand: A New Paradigm for Regulation of Osteoclastogenesis and Bone Resorption

2000 • 327 citations

Age-related changes in vertebral trabecular bone architecture—assessed by a new method

1988 • 316 citations

Bonobo: The Forgotten Ape

1997 • 304 citations

Intermittently Administered Human Parathyroid Hormone(1–34) Treatment Increases Intracortical Bone Turnover and Porosity Without Reducing Bone Strength in the Humerus of Ovariectomized Cynomolgus Monkeys

2001 • 300 citations

Bone mineral density reflects bone mass but also the degree of mineralization of bone: Therapeutic implications

1997 • 294 citations

The mechanism of coupling: a role for the vasculature

2000 • 280 citations

Diet and Primate Evolution

1993 • 277 citations

Effects of Ethnicity and Age or Menopause on the Remodeling and Turnover of Iliac Bone: Implications for Mechanisms of Bone Loss

1997 • 250 citations

Morphology of the Osteon

1966 • 234 citations

The Thickness of Human Vertebral Cortical Bone and its Changes in Aging and Osteoporosis: A Histomorphometric Analysis of the Complete Spinal Column from Thirty-Seven Autopsy Specimens

1997 • 208 citations

Effect of bone strain on cortical bone structure in macaques (Macaca mulatta)

1981 • 206 citations

Age- and sex-related changes in iliac cortical bone mass and remodeling

1993 • 204 citations

Dietary protein affects intestinal calcium absorption

1998 • 196 citations

Glucocorticoid hormone resistance during primate evolution: receptor-mediated mechanisms.

1982 • 178 citations

Characterization of the Onset of Menopause in the Rhesus Macaque1

1997 • 176 citations

A Genetic Linkage Map of the Baboon (Papio hamadryas) Genome Based on Human Microsatellite Polymorphisms

2000 • 173 citations

Effects of Raloxifene on Bone Mineral Density, Serum Cholesterol Concentrations, and Uterine Endometrium in Postmenopausal Women

1998 • 162 citations

Treatment with human parathyroid hormone (1-34) for 18 months increases cancellous bone volume and improves trabecular architecture in ovariectomized cynomolgus monkeys (Macaca fascicularis)

2001 • 160 citations

Heterogeneity of the skeleton: Comparison of the trabecular microarchitecture of the spine, the iliac crest, the femur, and the calcaneus

1996 • 155 citations

Hormone Replacement Therapy Prevents Osteoclastic Hyperactivity: A Histomorphometric Study in Early Postmenopausal Women

1999 • 151 citations

Effect of ethnicity and age or menopause on the structure and geometry of iliac bone

1996 • 144 citations

A Comparison of the Effects of Raloxifene and Estrogen on Bone in Postmenopausal Women1

2000 • 139 citations

Corticosteroids and Fractures: A Close Encounter of the Third Cell Kind

2000 • 135 citations

Menopause in female rhesus monkeys

1995 • 131 citations

A physical, chemical, and mechanical study of lumbar vertebrae from normal, ovariectomized, and nandrolone decanoate-treated cynomolgus monkeys (macaca fascicularis)

2000 • 126 citations

Cortical bone distribution in the femoral neck of hominoids: Implications for the locomotion ofAustralopithecus afarensis

1997 • 121 citations

Increased circulating concentrations of parathyroid hormone in healthy, young women consuming a protein-restricted diet

1997 • 120 citations

Bone functional changes in intact, ovariectomized, and ovariectomized, hormone-supplemented adult cynomolgus monkeys (Macaca fascicularis) evaluated by serum markers and dynamic histomorphometry

1994 • 118 citations

The Psychological Well-Being of Nonhuman Primates

1998 • 118 citations

Menopause in rhesus monkeys: Model for study of disorders in the human climacteric

1977 • 117 citations

Immobilization-associated osteoporosis in primates

1986 • 117 citations

Functions of the haversian system

1962 • 116 citations

Zoledronate Prevents the Development of Absolute Osteopenia Following Ovariectomy in Adult Rhesus Monkeys

1998 • 108 citations

Composite Pattern of Circulating LH, FSH, Estradiol, and Progesterone during the Menstrual Cycle in Cynomolgus Monkeys

1977 • 107 citations

Morphology of the Drifting Osteon

1999 • 106 citations

The bisphosphonate, alendronate, prevents bone loss in ovariectomized baboons

1992 • 103 citations

the mechanical or metabolic function of secondary osteonal bone in the monkey macaca fascicularis

1996 • 102 citations

Intervertebral variation in trabecular microarchitecture throughout the normal spine in relation to age

1995 • 101 citations

Primate cortical bone microstructure: Relationship to locomotion

1984 • 100 citations

Morphological and structural characteristics of the proximal femur in human and rat

1997 • 95 citations

The effects of gonadotrophin-releasing hormone agonists on iliac crest cancellous bone structure in women with endometriosis

1995 • 94 citations

Daily Treatment with Human Recombinant Parathyroid Hormone-(1–34), LY333334, for 1 Year Increases Bone Mass in Ovariectomized Monkeys*

1999 • 92 citations

Low Dietary Protein and Low Bone Density

2000 • 91 citations

Effect of treatment for 6 months with human parathyroid hormone (1-34) peptide in ovariectomized cynomolgus monkeys (Macaca fascicularis)

1999 • 90 citations

Bone mass in female cynomolgus macaques: A cross-sectional and longitudinal study by age

1994 • 90 citations

Baboons as an Animal Model for Genetic Studies of Common Human Disease

1997 • 89 citations

Inhibition of Cortical and Trabecular Bone Formation in the Long Bones of Immobilized Monkeys

1983 • 88 citations

Osteoclast precursors as leukocytes: importance of the area code

1998 • 85 citations

Bone mineral density, osteopenia, and osteoporosis in the rhesus macaques of Cayo Santiago

2000 • 82 citations

Plasma Cortisol Transport and Primate Evolution

1984 • 80 citations

Extremely high circulating levels of 1α,25-dihydroxyvitamin D3 in the marmoset, a new world monkey

1983 • 76 citations

Structural adaptations of the femur and humerus to arboreal and terrestrial environments in three species of macaque

1989 • 76 citations

Effects of age and sex on bone density in the rhesus monkey

1989 • 75 citations

A molecular phylogeny of the hominoid primates as indicated by two-dimensional protein electrophoresis.

1987 • 75 citations

Fluoride content in human iliac bone: Results in controls, patients with fluorosis, and osteoporotic patients treated with fluoride

1988 • 75 citations

Decreased Bone Mass and Strength in Ovariectomized Cynomolgus Monkeys (Macaca fascicularis)

1997 • 75 citations

Skeletal effects of aging in male rhesus monkeys

1999 • 75 citations

Redirection of Filial Attachments in Rhesus Monkeys: Dogs as Mother Surrogates

1974 • 73 citations

Skeletal Effects of Aging and Menopausal Status in Female Rhesus Macaques¹

1999 • 73 citations

Vaccine Studies Stymied by Shortage of Animals

2000 • 72 citations

Age- and gender-related changes in the distribution of osteocalcin in the extracellular matrix of normal male and female bone. Possible involvement of osteocalcin in bone remodeling.

1994 • 70 citations

Effects of ovariectomy on iliac trabecular bone in baboons (Papio anubis)

1986 • 70 citations

Tibial changes in experimental disuse osteoporosis in the monkey

1983 • 69 citations

Computer-Assisted 3D Reconstruction of Serial Sections of Cortical Bone to Determine the 3D Structure of Osteons

1999 • 67 citations

The effect of advancing age on bone mineral content of female rhesus monkeys

1996 • 67 citations

Aging in the musculoskeletal system of rhesus monkeys: III. Bone loss

1985 • 66 citations

Comparison of vertebral and peripheral mineral losses in disuse osteoporosis in monkeys.

1980 • 65 citations

Canalicular communication in the cortices of human long bones

1985 • 65 citations

Community water fluoridation, bone mineral density, and fractures: prospective study of effects in older women

2000 • 65 citations

Estimated intracortical bone turnover in the femur of growing macaques: Implications for their use as models in skeletal pathology

1992 • 63 citations

Aging and food restriction alter some indices of bone metabolism in male rhesus monkeys (Macaca mulatta).

1995 • 63 citations

Differences in Mineral Metabolism among Nonhuman Primates Receiving Diets with Only Vitamin D₃or Only Vitamin D₂*

1989 • 62 citations

Three-dimensional Modeling of the Effects of Parathyroid Hormone on Bone Distribution in Lumbar Vertebrae of Ovariectomized Cynomolgus Macaques

2000 • 61 citations

Effects of ovariectomy on vertebral trabecular bone in the cynomolgus monkey (Macaca fascicularis)

1986 • 59 citations

Energy Restriction Does Not Alter Bone Mineral Metabolism or Reproductive Cycling and Hormones in Female Rhesus Monkeys

2001 • 59 citations

The effect of dietary restriction on body composition in adult male and female rhesus macaques

1998 • 58 citations

A Potential Primate Model for Bone Loss Resulting from Medical Oophorectomy or Menopause*

1990 • 57 citations

Apparent age‐related bone loss among adult female Gombe chimpanzees

1989 • 56 citations

Longitudinal effect of tiludronate on bone mineral density, resonant frequency, and strength in monkeys

1992 • 56 citations

THE EFFECT OF ABRUPT CHANGES IN PLASMA CALCIUM CONCENTRATIONS ON RENAL FUNCTION AND ELECTROLYTE EXCRETION IN MAN AND MONKEY12

1958 • 55 citations

Efficacy of Levormeloxifene in the Prevention of Postmenopausal Bone Loss and on the Lipid Profile Compared to Low Dose Hormone Replacement Therapy¹

2001 • 54 citations

The androgenic anabolic steroid nandrolone decanoate prevents osteopenia and inhibits bone turnover in ovariectomized cynomolgus monkeys

1997 • 53 citations

A nonhuman primate model of age-related bone loss: a longitudinal study in male and premenopausal female rhesus monkeys

2001 • 52 citations

A non-human primate model for the study of osteoporosis and oral bone loss

1993 • 51 citations

Bone structure and turnover in the distal radius and iliac crest: A histomorphometric study

1996 • 51 citations

Serum concentrations of 1,25‐dihydroxyvitamin D₃ in Platyrrhini and Catarrhini: A phylogenetic appraisal

1985 • 51 citations

Contribution of the trabecular component to mechanical strength and bone mineral content of the femoral neck. An experimental study on cadaver bones

1988 • 50 citations

Immunolocalization of noncollagenous bone matrix proteins in lumbar vertebrae from intact and surgically menopausal cynomolgus monkeys

1993 • 50 citations

Vitamins D ₂ and D ₃ in New World Primates: Influence on Calcium Absorption

1967 • 50 citations

Histomorphometry of iliac crest trabecular bone in adult male baboons in captivity

1993 • 50 citations

Primary structure of monkey osteocalcin

1982 • 50 citations

The effect of ovariectomy on spine bone mineral density in rhesus monkeys

1989 • 49 citations

Plasma estrogen, progestin, and luteinizing hormone during the normal menstrual cycle in the baboon: Role of luteinizing hormone

1977 • 47 citations

Social housing of monkeys and apes: group formations.

1991 • 47 citations

Bone in the marmoset: A resemblance to vitamin D-dependent rickets, type II

1986 • 47 citations

The impact of chronic estrogen deprivation on immunologic parameters in the ovariectomized rhesus monkey (Macaca mulatta) model of menopause

2001 • 46 citations

The sequence of epiphysial union in Old World monkeys

1943 • 46 citations

QUANTITATIVE STUDIES ON BONE RECONSTRUCTION. 1.

1963 • 45 citations

Preservation of bone mass in hypogonadal female monkeys with recombinant human growth hormone administration.

1992 • 45 citations

Calorie Restriction and Skeletal Mass in Rhesus Monkeys (Macaca mulatta): Evidence for an Effect Mediated Through Changes in Body Size

2001 • 44 citations

Nutritional modulation of aging in nonhuman primates.

1999 • 44 citations

Effects of age, sex, and heredity on measures of bone mass in baboons (Papio hamadryas)

1995 • 43 citations

The effect of differing dietary calcium and phosphorus contents on mineral metabolism and bone histomorphometry in young vitamin D-replete baboons

1984 • 43 citations

CONCENTRATIONS OF OESTRADIOL-17β AND PROGESTERONE IN THE PERIPHERAL PLASMA OF THE CYNOMOLGUS MONKEY (MACACA FASCICULARIS) IN RELATION TO THE LENGTH OF THE MENSTRUAL CYCLE AND ITS COMPONENT PHASES

1978 • 43 citations

The mechanism of end-organ resistance to 1α,25-dihydroxycholecalciferol in the common marmoset

1985 • 42 citations

The Weight-Rearing Capacity of Structural Elements in Femoral Necks

1956 • 42 citations

Proteins in the Heat Shock-70 Family Specifically Bind 25-Hydroxyvitamin D₃and 17β-Estradiol¹

1998 • 42 citations

Effect of naturally reduced ovarian function on plasma lipoprotein and 27-hydroxycholesterol levels in baboons (Papio sp.)

1998 • 40 citations

Social behavior and gender in biomedical investigations using monkeys: studies in atherogenesis.

1991 • 39 citations

The Therapy of Osteoporosis and the Importance of Cortical Bone

1997 • 39 citations

Cloning and Expression of the Glucocorticoid Receptor from the Squirrel Monkey (Saimiri boliviensis boliviensis), a Glucocorticoid-Resistant Primate¹

1997 • 38 citations

Soy Protein Isolate Diet Does Not Prevent Increased Cortical Bone Turnover in Ovariectomized Macaques

1998 • 38 citations

Bone Physiology During Pregnancy and Lactation in Young Macaques

1999 • 37 citations

Evaluation of vertebral volumetric vs. areal bone mineral density during growth

1997 • 37 citations

Guidelines for Prevention of Herpesvirus Simiae (B Virus) Infection in Monkey Handlers

1987 • 36 citations

Changes in Bone Mass and Bone Biomarkers of Cynomolgus Monkeys during Pregnancy and Lactation¹

1998 • 36 citations

Ovulation Inhibition by Administration of Weekly Gonadotropin-Releasing Hormone Antagonist

1986 • 35 citations

Iliac biopsy for histomorphometric analysis of trabecular bone in cynomolgus monkeys and baboons.

1987 • 34 citations

Real-Time In Vivo Loading in the Lumbar Spine

2000 • 32 citations

Maintenance of Ovulatory Menstrual Cycles in Chronically Cannulated Monkeys: A Vest and Mobile Tether Assembly

1983 • 31 citations

Use of peripheral quantitative computed tomography for densitometry of the femoral neck and spine in cynomolgus monkeys (Macaca fascicularis)

1999 • 31 citations

Risk of occupational exposure to potentially infectious nonhuman primate materials and to simian immunodeficiency virus

1997 • 31 citations

Bone Morphogenetic Protein-2 Stimulates Differentiation of Cultured Spinal Ligament Cells from Patients with Ossification of the Posterior Longitudinal Ligament

1997 • 30 citations

Metabolism of 1 alpha-hydroxyvitamin D2 to activated dihydroxyvitamin D 2 metabolites decreases endogenous 1 alpha, 25-dihydroxyvitamin D 3 in rats and monkeys.

1995 • 30 citations

Development of osteopenia in ovariectomized cynomolgus monkeys (Macaca fascicularis)

1995 • 30 citations

The anesthetic isoflurane decreases ionized calcium and increases parathyroid hormone and osteocalcin in cynomolgus monkeys

1998 • 29 citations

Bone measurement by enhanced contrast image analysis: Ovariectomized and intact Macaca fascicularis as a model for human postmenopausal osteoporosis

1985 • 29 citations

Changes in Bone Turnover During the Menstrual Cycle in Cynomolgus Monkeys

2000 • 29 citations

Levormeloxifene prevents increased bone turnover and vertebral bone loss following ovariectomy in cynomolgus monkeys

2001 • 29 citations

Noninvasive markers of bone metabolism in the rhesus monkey: Normal effects of age and gender

1996 • 29 citations

Bone mass and bone cellular variations after five months of physical training in rhesus monkeys: Histomorphometric study

1992 • 29 citations

Cortical Remodeling Following Suppression of Endogenous Estrogen with Analogs of Gonadotrophin Releasing Hormone

1997 • 27 citations

Effects on bone of oral hormone replacement therapy initiated 2 years after ovariectomy in young adult monkeys

1998 • 27 citations

Bone Changes in Oophorectomized Monkeys

1987 • 27 citations

Species differences in the binding kinetics of 25-hydroxyvitamin D₃ to vitamin D binding protein

1990 • 25 citations

Histomorphometry and bone biomarkers in cynomolgus females: a study in young, mature, and old monkeys

1999 • 25 citations

Journal of Bone and Mineral Research

1993 • 25 citations

Changes in Bone Mineral Density of Lumbar Vertebrae after Parturition in African Green Monkeys (Cercopithecus aethiops).

1996 • 25 citations

Primate models of osteoporosis.

1998 • 23 citations

The Association Between Water-borne Fluoride and Bone Mineral Density in Older Adults

1998 • 22 citations

CALCIUM METABOLISM OF THE NORMAL RHESUS MONKEY*

1961 • 22 citations

Sampling of cortical and trabecular bone for lead analysis: method development in a study of lead mobilization during pregnancy.

1992 • 21 citations

Radioimmunoassay of parathyroid hormone (parathyrin) in monkey and man.

1977 • 21 citations

Microradiographs and autoradiographs of cortical bone from monkeys injected with 90Sr.

1953 • 21 citations

Frequency and maintenance of genetic variability in natural populations of Macaca fascicularis

1972 • 19 citations

The architecture of cancellous and cortical bone in femoral neck fracture

1990 • 19 citations

Relationships between ovarian morphology, vaginal cytology, serum progesterone, and urinary immunoreactive pregnanediol during the menstrual cycle of the cynomolgus monkey

1986 • 18 citations

Polymorphism of the vitamin D binding protein (DBP) among primates: An evolutionary analysis

1987 • 18 citations

Lofland HB: Biological activities of vitamins D2 and D3 for growing squirrel monkeys.

1967 • 18 citations

PERIPHERAL PLASMA LEVELS OF OESTRONE, OESTRADIOL-17β AND PROGESTERONE DURING OVULATORY MENSTRUAL CYCLES IN THE RHESUS MONKEY WITH SPECIAL REFERENCE TO THE ONSET OF MENSTRUATION

1973 • 18 citations

Comparison of the Menstrual Cycle of Cynomolgus and Rhesus Monkeys

1969 • 17 citations

Short-Term Effects of Growth Hormone and Insulin-Like Growth Factor I on Cancellous Bone in Rhesus Macaque Monkeys*

1997 • 17 citations

Effects of Ovarian Tissue Reduction on the Menstrual Cycle: Persistent Normalcy after Near-Total Oophorectomy1

1989 • 16 citations

Ovariectomy does not induce osteopenia through interleukin-6 in rhesus monkeys (Macaca mulatta)

2000 • 15 citations

A longitudinal study of calcium regulation in a nonhuman primate model of parenteral nutrition

1998 • 14 citations

Prolonged inhibition of normal ovarian cycles in the rat and cynomolgus monkeys following a single s.c. injection of danazol

1997 • 14 citations

Accuracy and reproducibility of lumbar bone mineral status determined by dual photon absorptiometry in live male cynomolgus macaques (Macaca fascicularis).

1990 • 13 citations

Radioimmunoassay of calcitonin in the plasma of rhesus monkey and man.

1978 • 13 citations

Evaluation of Factors Determining the Tissue-Level Haversian Bone Formation Rate in Man

1970 • 13 citations

Central region-of-interest analysis of lumbar spine densitometry demonstrates lower bone mass in older rhesus monkeys

1999 • 13 citations

An Overview of Biohazards Associated With Nonhuman Primates

1987 • 12 citations

Suppression of Ovarian Estradiol Secretion by a Single Injection of Antide in Cynomolgus Monkeys during the Early Follicular Phase: Immediate, Sustained, and Reversible Actions*

1991 • 12 citations

Unbiased determination of cytokine localization in bone: colocalization of interleukin-6 with osteoblasts in serial sections from monkey vertebrae

2000 • 10 citations

Measurement of serum bone‐specific alkaline phosphatase activity in cynomolgus macaques

1999 • 9 citations

Age-related Changes in Bone Mineral Density, Mean Width and Area of the Lumbar Vertebrae in Male African Green Monkeys (<I>Cercopithecus aethiops</I>)

1994 • 9 citations

Structural Histomorphometric Analysis of Cortical, Transitional, and Cancellous Vertebral Bone in Intact, Ovariectomized, and Nandrolone-Treated Cynomolgus Monkeys (Macaca fascicularis)

1997 • 9 citations

Fine structure of the parathyroid glands in baboons, <i>Papio hamadryas</i> in response to experimental hypercorticoidism

1980 • 9 citations

PIONEERS OF OSTEOGENY

1952 • 8 citations

Method for transilial bone biopsy in baboons.

1991 • 8 citations

A new technique for iliac crest biopsy in rhesus monkeys for use in weightlessness experiments: some results of ground studies.

1988 • 8 citations

Evaluation of Serum Parameters Relevant to Vitamin D Status in Tamarins

1987 • 8 citations

Parathyroid hormone, ionised calcium, and potentially interacting variables in plasma of an Old World primate

1993 • 7 citations

Thyroid calcitonin cells and parathyroid gland of the Indian rhesus monkey Macaca mulatta in response to experimental hypercalcaemia.

1979 • 6 citations

Comparison of calcium and phosphorus excretion with bone density changes during restraint in immature Macaca nemestrina primates.

1972 • 5 citations

Genetic polymorphism of the vitamin D‐binding protein (DBP) in crab‐eating macaques (Macaca fascicularis)

1991 • 4 citations

Rib biopsy technique for cortical bone evaluation in rhesus monkeys (Macaca mulatta).

1999 • 4 citations

Percutaneous trephine biopsy of the vertebral body in the rhesus monkey (Macaca mulatta).

1985 • 4 citations

Physiologic and metabolic changes in Macaca nemestrina on two types of diets during restraint and non-restraint. II. Bone density changes.

1968 • 4 citations