Regulation of Hepatic Drug-Metabolizing Enzymes in Germ-Free Mice by Conventionalization and Probiotics

Ulcerative Colitis

2001 • 3,087 citations

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

2001 • 1,271 citations

Induction of phase I, II and III drug metabolism/transport by xenobiotics

2005 • 1,218 citations

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

2014 • 807 citations

Probiotic use in clinical practice: what are the risks?

2006 • 735 citations

VSL#3 Probiotic-Mixture Induces Remission in Patients with Active Ulcerative Colitis

2005 • 723 citations

Probiotics: Definition, Sources, Selection, and Uses

2008 • 591 citations

PHASE II DRUG METABOLIZING ENZYMES

2010 • 526 citations

Nutrient-sensing nuclear receptors coordinate autophagy

2014 • 448 citations

Colonization-Induced Host-Gut Microbial Metabolic Interaction

2011 • 375 citations

Cytochrome P4503A (CYP3A) metabolism: Prediction ofIn Vivo activity in humans

1996 • 308 citations

Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice

2012 • 293 citations

Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases

2008 • 277 citations

CLOCK is involved in the circadian transactivation of peroxisome-proliferator-activated receptor α (PPARα) in mice

2005 • 276 citations

Coordinated Regulation of Hepatic Phase I and II Drug-Metabolizing Genes and Transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-Null Mice

2012 • 234 citations

Peroxisome Proliferator-activated Receptor α Controls the Hepatic CYP4A Induction Adaptive Response to Starvation and Diabetes

1998 • 211 citations

Molecular quantification of lactic acid bacteria in fermented milk products using real-time quantitative PCR

2004 • 193 citations

Probiotics: an update

2014 • 186 citations

Characterization of human epigenomes

2009 • 146 citations

Induction of Mouse UDP-Glucuronosyltransferase mRNA Expression in Liver and Intestine by Activators of Aryl-Hydrocarbon Receptor, Constitutive Androstane Receptor, Pregnane X Receptor, Peroxisome Proliferator-Activated Receptor α, and Nuclear Factor Erythroid 2-Related Factor 2

2009 • 136 citations

Probiotic Mix VSL#3 Is Effective Adjunctive Therapy for Mild to Moderately Active Ulcerative Colitis

2014 • 123 citations

The transcriptional regulatory code of eukaryotic cells – insights from genome-wide analysis of chromatin organization and transcription factor binding

2006 • 118 citations

Gut Microbiota-Mediated Drug-Antibiotic Interactions

2015 • 112 citations

RNA-Seq Quantification of Hepatic Drug Processing Genes in Germ-Free Mice

2015 • 108 citations

CYP4F Enzymes Are the Major Enzymes in Human Liver Microsomes That Catalyze the O-Demethylation of the Antiparasitic Prodrug DB289 [2,5-Bis(4-amidinophenyl)furan-bis-O-methylamidoxime]

2006 • 89 citations

Intestinal flora induces the expression of Cyp3a in the mouse liver

2009 • 87 citations

Regulation of Sulfotransferase Enzymes by Prototypical Microsomal Enzyme Inducers in Mice

2007 • 85 citations

Gut microbiota: a source of novel tools to reduce the risk of human disease?

2014 • 85 citations

Developmental Regulation of Drug-Processing Genes in Livers of Germ-Free Mice

2015 • 82 citations

ChIPing the cistrome of PXR in mouse liver

2010 • 69 citations

Induction of Hepatic Glutathione S-Transferases in Male Mice by Prototypes of Various Classes of Microsomal Enzyme Inducers

2008 • 68 citations

Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11

2007 • 55 citations

Amelioration of DSS-induced murine colitis by VSL#3 supplementation is primarily associated with changes in ileal microbiota composition.

2014 • 47 citations

A microarray analysis of gnotobiotic mice indicating that microbial exposure during the neonatal period plays an essential role in immune system development

2012 • 45 citations

Quantitative Detection of Probiotic Bifidobacterium Strains in Bacterial Mixtures by Using Real-time PCR

2003 • 44 citations

Dysfunction of Organic Anion Transporting Polypeptide 1a1 Alters Intestinal Bacteria and Bile Acid Metabolism in Mice

2012 • 37 citations

Effect of a Probiotic Preparation (VSL#3) in Patients with Mild to Moderate Ulcerative Colitis

2012 • 35 citations

Tissue Distribution, Ontogeny, and Chemical Induction of Aldo-Keto Reductases in Mice

2013 • 33 citations

Partnering with gastroenterologists to evaluate patients with chronic constipation.

2005 • 12 citations

Probiotics in the management of inflammatory bowel disease.

2005 • 8 citations

Deleted Work

1955 • 0 citations