Developmental Regulation of Drug-Processing Genes in Livers of Germ-Free Mice

An obesity-associated gut microbiome with increased capacity for energy harvest

2006 • 11,120 citations

Structure, function and diversity of the healthy human microbiome

2012 • 10,447 citations

Diet rapidly and reproducibly alters the human gut microbiome

2013 • 8,439 citations

Human gut microbiome viewed across age and geography

2012 • 6,893 citations

Obesity alters gut microbial ecology

2005 • 5,818 citations

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

2011 • 4,704 citations

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

2013 • 3,746 citations

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

2013 • 2,766 citations

Development of the Human Infant Intestinal Microbiota

2007 • 2,714 citations

Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

2007 • 2,435 citations

Succession of microbial consortia in the developing infant gut microbiome

2010 • 2,291 citations

The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing

2008 • 2,252 citations

Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation

2010 • 2,149 citations

Developmental Pharmacology — Drug Disposition, Action, and Therapy in Infants and Children

2003 • 2,148 citations

Antibiotics in early life alter the murine colonic microbiome and adiposity

2012 • 1,502 citations

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

2001 • 1,271 citations

The Intestinal Microbiome in Early Life: Health and Disease

2014 • 829 citations

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

2014 • 807 citations

Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism

2009 • 717 citations

Reproducible Community Dynamics of the Gastrointestinal Microbiota following Antibiotic Perturbation

2009 • 526 citations

Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism

2010 • 524 citations

Association of Antibiotics in Infancy With Early Childhood Obesity

2014 • 454 citations

Colonization-Induced Host-Gut Microbial Metabolic Interaction

2011 • 375 citations

Effects of Lactobacillus rhamnosus Strain GG in Pediatric Obesity‐related Liver Disease

2011 • 311 citations

Infant antibiotic exposure and the development of childhood overweight and central adiposity

2014 • 306 citations

Tenofovir Nephrotoxicity: 2011 Update

2011 • 281 citations

Coordinated Regulation of Hepatic Phase I and II Drug-Metabolizing Genes and Transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-Null Mice

2012 • 234 citations

Intestinal Microbiota Regulate Xenobiotic Metabolism in the Liver

2009 • 223 citations

Tissue- and Gender-Specific mRNA Expression of UDP-Glucuronosyltransferases (UGTs) in Mice

2006 • 182 citations

Interindividual Variability in Hepatic Organic Anion-Transporting Polypeptides and P-Glycoprotein (ABCB1) Protein Expression: Quantification by Liquid Chromatography Tandem Mass Spectroscopy and Influence of Genotype, Age, and Sex

2013 • 181 citations

Children Versus Adults: Pharmacokinetic and Adverse‐Effect Differences

2002 • 177 citations

Probiotics during weaning reduce the incidence of eczema

2009 • 175 citations

Developmental expression of drug metabolizing enzymes: Impact on disposition in neonates and young children

2012 • 168 citations

Tissue Distribution and Gender-Divergent Expression of 78 Cytochrome P450 mRNAs in Mice

2011 • 164 citations

TISSUE DISTRIBUTION AND ONTOGENY OF MOUSE ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPS)

2005 • 161 citations

Tissue Distribution, Ontogeny, and Regulation of Aldehyde Dehydrogenase (Aldh) Enzymes mRNA by Prototypical Microsomal Enzyme Inducers in Mice

2007 • 139 citations

Ontogeny of Human Hepatic and Intestinal Transporter Gene Expression during Childhood: Age Matters

2014 • 137 citations

Role of the hepatocyte nuclear factor 4α in control of the pregnane X receptor during fetal liver development

2003 • 137 citations

Differences in absorption, distribution, metabolism and excretion of xenobiotics between the paediatric and adult populations

2005 • 133 citations

TISSUE DISTRIBUTION AND ONTOGENY OF ORGANIC CATION TRANSPORTERS IN MICE

2005 • 131 citations

Breast-fed and bottle-fed infant rhesus macaques develop distinct gut microbiotas and immune systems

2014 • 129 citations

Compensatory Induction of Liver Efflux Transporters in Response to ANIT-Induced Liver Injury Is Impaired in FXR-Null Mice

2009 • 118 citations

Molecular analysis of colonized bacteria in a human newborn infant gut.

2005 • 114 citations

Optimized Approaches for Quantification of Drug Transporters in Tissues and Cells by MRM Proteomics

2014 • 105 citations

Three Patterns of Cytochrome P450 Gene Expression during Liver Maturation in Mice

2008 • 102 citations

Constitutive mRNA Expression of Various Glutathione S-Transferase Isoforms in Different Tissues of Mice

2007 • 95 citations

Regulation of hepatic bile acid transporters Ntcp and Bsep expression

2007 • 92 citations

Intestinal flora induces the expression of Cyp3a in the mouse liver

2009 • 87 citations

Transcriptional Regulation of Cytochrome P450 Genes by the Nuclear Receptor Hepatocyte Nuclear Factor 4-Alpha

2009 • 85 citations

Tissue distribution, ontogeny and induction of the transporters Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression levels in mice

2008 • 70 citations

Mechanism of Gender-Divergent UDP-Glucuronosyltransferase mRNA Expression in Mouse Liver and Kidney

2009 • 69 citations

Ontogeny of Novel Cytochrome P450 Gene Isoforms during Postnatal Liver Maturation in Mice

2012 • 59 citations

RNA Sequencing Reveals Dynamic Changes of mRNA Abundance of Cytochromes P450 and Their Alternative Transcripts during Mouse Liver Development

2012 • 57 citations

Mechanisms of gender-specific regulation of mouse sulfotransferases (Sults)

2010 • 55 citations

Ciprofloxacin Suppresses Cyp3a in Mouse Liver by Reducing Lithocholic Acid-producing Intestinal Flora

2009 • 55 citations

Regulation of Hepatic Drug Metabolism: Role of the Nuclear Receptors PXR and CAR

2002 • 52 citations

Age-related differences in hepatic drug clearance in children: Studies with lorazepam and antipyrine

1991 • 48 citations

Comparison of the toxicity of chemicals in newborn rats to bile duct-ligated and sham-operated rats and mice

1973 • 45 citations

Endocrine Regulation of Gender-Divergent Mouse Organic Anion-Transporting Polypeptide (Oatp) Expression

2006 • 45 citations

Probiotic effects on T‐cell maturation in infants during weaning

2011 • 45 citations

Growth Hormone Pulse‐Activated STAT5 Signalling: A Unique Regulatory Mechanism Governing Sexual Dimorphism of Liver Gene Expression

2000 • 45 citations

RNA-Seq Reveals Different mRNA Abundance of Transporters and Their Alternative Transcript Isoforms During Liver Development

2012 • 44 citations

RNA-Sequencing Quantification of Hepatic Ontogeny and Tissue Distribution of mRNAs of Phase II Enzymes in Mice

2013 • 43 citations

Hepatic Xenobiotic Metabolizing Enzyme and Transporter Gene Expression through the Life Stages of the Mouse

2011 • 37 citations

Impact of probiotic feeding during weaning on the serum lipid profile and plasma metabolome in infants

2012 • 32 citations

Luciferin IPA–Based Higher Throughput Human Hepatocyte Screening Assays for CYP3A4 Inhibition and Induction

2011 • 30 citations

RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice

2013 • 29 citations

Effects of Lactobacillus casei on the expression and the activity of cytochromes P450 and on the CYP mRNA level in the intestine and the liver of male rats.

2011 • 23 citations

Comparison of Heavy Labeled (SIL) Peptide versus SILAC Protein Internal Standards for LC-MS/MS Quantification of Hepatic Drug Transporters

2014 • 19 citations

Age-Dependent Activity of the Uptake Transporters Ntcp and Oatp1b2 in Male Rat Hepatocytes: From Birth Till Adulthood

2014 • 19 citations

Gastrectomy Increases the Expression of Hepatic Cytochrome P450 3A by Increasing Lithocholic Acid-Producing Enteric Bacteria in Mice

2013 • 13 citations