DNA damage response in cisplatin-induced nephrotoxicity

Cisplatin in cancer therapy: Molecular mechanisms of action

2014 • 4,537 citations

The DNA Damage Response: Making It Safe to Play with Knives

2010 • 3,921 citations

Cellular processing of platinum anticancer drugs

2005 • 3,539 citations

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

2001 • 2,226 citations

Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies

2008 • 1,713 citations

Mechanisms of Cisplatin Nephrotoxicity

2010 • 1,455 citations

Mechanisms and functions of DNA mismatch repair

2007 • 1,293 citations

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

2012 • 786 citations

Biochemical Mechanisms of Cisplatin Cytotoxicity

2007 • 623 citations

Cellular Responses to Cisplatin‐Induced DNA Damage

2010 • 504 citations

Mismatch repair and DNA damage signalling

2004 • 388 citations

CHK2 kinase in the DNA damage response and beyond

2014 • 376 citations

Cisplatin-Induced Renal Cell Apoptosis: Caspase 3-Dependent and -Independent Pathways

2002 • 356 citations

Inhibition of the c-Abl–TAp63 pathway protects mouse oocytes from chemotherapy-induced death

2009 • 333 citations

Yap1 Phosphorylation by c-Abl Is a Critical Step in Selective Activation of Proapoptotic Genes in Response to DNA Damage

2008 • 324 citations

Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells

2008 • 319 citations

ATR-Chk2 Signaling in p53 Activation and DNA Damage Response during Cisplatin-induced Apoptosis

2007 • 286 citations

Regulation of cell death by the Abl tyrosine kinase

2000 • 278 citations

Common mechanisms of PIKK regulation

2009 • 267 citations

Induction of p21WAF1/CIP1/SDI1 in kidney tubule cells affects the course of cisplatin-induced acute renal failure.

1998 • 265 citations

Chemotherapy induced DNA damage response

2013 • 252 citations

Checkpoint kinase 1 in DNA damage response and cell cycle regulation

2013 • 243 citations

Activation and involvement of p53 in cisplatin-induced nephrotoxicity

2007 • 224 citations

ATM regulates ATR chromatin loading in response to DNA double-strand breaks

2006 • 221 citations

Hesperidin attenuates cisplatin-induced acute renal injury by decreasing oxidative stress, inflammation and DNA damage

2013 • 211 citations

The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73

2006 • 203 citations

Regulation of PUMA-α by p53 in cisplatin-induced renal cell apoptosis

2006 • 199 citations

ATM and ATR: Components of an Integrated Circuit

2007 • 197 citations

The cell cycle and acute kidney injury

2009 • 191 citations

Cisplatin-induced Kidney Dysfunction and Perspectives on Improving Treatment Strategies

2014 • 191 citations

The Mre11/Rad50/Nbs1 Complex and Its Role as a DNA Double-Strand Break Sensor for ATM

2005 • 181 citations

p53-dependent Caspase-2 Activation in Mitochondrial Release of Apoptosis-inducing Factor and Its Role in Renal Tubular Epithelial Cell Injury

2005 • 171 citations

Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin

2003 • 159 citations

Tubular p53 Regulates Multiple Genes to Mediate AKI

2014 • 146 citations

Regulation and Pathological Role of p53 in Cisplatin Nephrotoxicity

2008 • 144 citations

Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer

2011 • 136 citations

NEK8 Links the ATR-Regulated Replication Stress Response and S Phase CDK Activity to Renal Ciliopathies

2013 • 134 citations

Nucleotide excision repair: Why is it not used to predict response to platinum-based chemotherapy?

2014 • 132 citations

ATR and Chk1 Suppress a Caspase-3–Dependent Apoptotic Response Following DNA Replication Stress

2009 • 129 citations

Protection of renal cells from cisplatin toxicity by cell cycle inhibitors

2004 • 121 citations

Role of the Increase in p21 in Cisplatin-Induced Acute Renal Failure in Rats

2001 • 110 citations

Regulation of p73 by c-Abl through the p38 MAP kinase pathway

2002 • 109 citations

Induction of JNK and c-Abl signalling by cisplatin and oxaliplatin in mismatch repair-proficient and -deficient cells

1999 • 108 citations

Dependence of Cisplatin-Induced Cell Death In Vitro and In Vivo on Cyclin-Dependent Kinase 2

2006 • 97 citations

Activation of MEK Kinase 1 by the c-Abl Protein Tyrosine Kinase in Response to DNA Damage

2000 • 93 citations

Nutlin-3 Protects Kidney Cells during Cisplatin Therapy by Suppressing Bax/Bak Activation

2006 • 92 citations

Effect of JNK inhibition on cisplatin-induced renal damage

2007 • 91 citations

hMSH2 Recruits ATR to DNA Damage Sites for Activation during DNA Damage-induced Apoptosis

2011 • 91 citations

Cell cycle control in the kidney

2014 • 90 citations

Repression of ATR pathway by miR-185 enhances radiation-induced apoptosis and proliferation inhibition

2013 • 87 citations

Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis

2010 • 86 citations

Autophagy in Acute Kidney Injury

2013 • 84 citations

Mismatch Repair Protein Deficiency Compromises Cisplatin-induced Apoptotic Signaling

2009 • 79 citations

Nuclear trafficking of pro-apoptotic kinases in response to DNA damage

2008 • 75 citations

c-Jun Regulates the Stability and Activity of the p53 Homologue, p73

2004 • 73 citations

Photoaffinity Isolation and Identification of Proteins in Cancer Cell Extracts that Bind to Platinum‐Modified DNA

2008 • 70 citations

DNA damage response in renal ischemia–reperfusion and ATP-depletion injury of renal tubular cells

2014 • 66 citations

Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints

2011 • 59 citations

DNA Damage Recognition via Activated ATM and p53 Pathway in Nonproliferating Human Prostate Tissue

2010 • 55 citations

The induction of cell cycle regulatory and DNA repair proteins in cisplatin-induced acute renal failure

2004 • 55 citations

Aven-Dependent Activation of ATM Following DNA Damage

2008 • 51 citations

Enabling Death by the Abl Tyrosine Kinase: Mechanisms for Nuclear Shuttling of c-Abl in Response to DNA Damage

2005 • 51 citations

c-Abl phosphorylation of ΔNp63α is critical for cell viability

2010 • 51 citations

Targeting and processing of site‐specific DNA interstrand crosslinks

2010 • 50 citations

Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: inactivation of its kinase activity toward p53

2006 • 50 citations

Cell cycle regulation: Repair and regeneration in acute renal failure

2004 • 50 citations

Initiation of DNA interstrand cross‐link repair in mammalian cells

2010 • 43 citations

MLH1- and ATM-dependent MAPK Signaling Is Activated through c-Abl in Response to the Alkylator N-Methyl-N′-nitro-N′-nitrosoguanidine

2007 • 41 citations

Aven blocks DNA damage-induced apoptosis by stabilising Bcl-xL

2010 • 36 citations

Mechanisms, function and clinical applications of DNp73

2013 • 35 citations

Histone H2AX Phosphorylation Independent of ATM after X-irradiation in Mouse Liver and Kidney in situ

2008 • 33 citations

Cdk2-dependent phosphorylation of p21 regulates the role of Cdk2 in cisplatin cytotoxicity

2011 • 32 citations

Platinum-induced kidney damage: Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury

2015 • 32 citations

Involvement of p53-transactivated Puma in cisplatin-induced renal tubular cell death

2008 • 31 citations

Genetic disruption of Abl nuclear import reduces renal apoptosis in a mouse model of cisplatin-induced nephrotoxicity

2013 • 29 citations

Delayed activation of Bax by DNA damage in embryonic stem cells with knock-in mutations of the Abl nuclear localization signals

2007 • 28 citations

The DNA Damage Response Kinases DNA-dependent Protein Kinase (DNA-PK) and Ataxia Telangiectasia Mutated (ATM) Are Stimulated by Bulky Adduct-containing DNA

2011 • 28 citations

Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl

2011 • 27 citations

Cisplatin upregulates MSH2 expression by reducing miR-21 to inhibit A549 cell growth

2012 • 23 citations

DNA Damage to a Single Chromosome End Delays Anaphase Onset

2014 • 20 citations

Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression

2013 • 18 citations

Detection of Early Abl Kinase Activation after Ionizing Radiation by Using a Peptide Biosensor

2012 • 17 citations

Frequencies of mutagenic translesion DNA synthesis over cisplatin-guanine intra-strand crosslinks in lacZ plasmids propagated in human cells

2014 • 14 citations

Comparative thermal and thermodynamic study of DNA chemically modified with antitumor drug cisplatin and its inactive analog transplatin

2014 • 13 citations