Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints

The DNA damage response: putting checkpoints in perspective

2000 • 3,147 citations

Cell-cycle checkpoints and cancer

2004 • 2,699 citations

Chk1 is an essential kinase that is regulated by Atr and required for the G₂/M DNA damage checkpoint

2000 • 1,583 citations

Chk1 and Chk2 kinases in checkpoint control and cancer

2003 • 1,458 citations

Mitotic and G ₂ Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

1997 • 1,332 citations

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

1997 • 1,285 citations

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

2001 • 1,036 citations

Rapid Destruction of Human Cdc25A in Response to DNA Damage

2000 • 768 citations

When Checkpoints Fail

1997 • 622 citations

A Long Twentieth Century of the Cell Cycle and Beyond

2000 • 602 citations

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

1999 • 580 citations

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A

2003 • 521 citations

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

2003 • 489 citations

Aberrant cell cycle checkpoint function and early embryonic death in Chk1^−/− mice

2000 • 466 citations

Fission yeast chkl protein kinase links the rad checkpoint pathway to cdc2

1993 • 464 citations

New Insights into Checkpoint Kinase 1 in the DNA Damage Response Signaling Network

2010 • 413 citations

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

2000 • 412 citations

Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation

1997 • 392 citations

Centrosome-associated Chk1 prevents premature activation of cyclin-B–Cdk1 kinase

2004 • 334 citations

Activation of mammalian Chk1 during DNA replication arrest

2001 • 307 citations

ATR-Chk2 Signaling in p53 Activation and DNA Damage Response during Cisplatin-induced Apoptosis

2007 • 286 citations

Chk1 promotes replication fork progression by controlling replication initiation

2010 • 283 citations

Positive Regulation of Wee1 by Chk1 and 14-3-3 Proteins

2001 • 277 citations

Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

2010 • 256 citations

Chk1 is haploinsufficient for multiple functions critical to tumor suppression

2004 • 244 citations

RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma

2011 • 240 citations

Chk1 Is Required for Spindle Checkpoint Function

2007 • 230 citations

Implications for Chk1 Regulation: The 1.7 Å Crystal Structure of Human Cell Cycle Checkpoint Kinase Chk1

2000 • 192 citations

Chk1 Requirement for High Global Rates of Replication Fork Progression during Normal Vertebrate S Phase

2006 • 173 citations

Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest

2002 • 150 citations

Cell-cycle checkpoint kinases: checking in on the cell cycle

2000 • 149 citations

Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

2008 • 130 citations

Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1)

2006 • 125 citations

hMSH2 Recruits ATR to DNA Damage Sites for Activation during DNA Damage-induced Apoptosis

2011 • 91 citations

Checking Out the Centrosome

2004 • 78 citations

Targeting the checkpoint kinase Chk1 in cancer therapy

2010 • 77 citations

Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity

2009 • 76 citations

Regulation of Chk1

2009 • 75 citations

Regulation of Chk1 Kinase by Autoinhibition and ATR-mediated Phosphorylation

2004 • 73 citations

Cross-talk between Chk1 and Chk2 in double-mutant thymocytes

2007 • 59 citations

Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53

2010 • 46 citations

DNA damage checkpoint maintenance through sustained Chk1 activity

2004 • 44 citations

Exercising Restraints: Role of Chk1 in Regulating the Onset and Progression of Unperturbed Mitosis in Vertebrate Cells

2007 • 29 citations