Nuclear trafficking of pro-apoptotic kinases in response to DNA damage

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

2000 • 1,155 citations

Protein Kinase C: Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular Interactions

2001 • 966 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

The DNA-dependent protein kinase

1999 • 896 citations

Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase

2003 • 843 citations

In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase

1990 • 783 citations

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21

2006 • 684 citations

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum.

1977 • 587 citations

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

1999 • 584 citations

Differential Reactivity of a Novel Monoclonal Antibody (DF3) with Human Malignant versus Benign Breast Tumors

1984 • 583 citations

A Myristoyl/Phosphotyrosine Switch Regulates c-Abl

2003 • 463 citations

Regulation of cell apoptosis by protein kinase c delta.

2003 • 413 citations

14-3-3 proteins: regulation of subcellular localization by molecular interference

2000 • 410 citations

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

2006 • 383 citations

Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast.

1994 • 346 citations

p53DINP1, a p53-Inducible Gene, Regulates p53-Dependent Apoptosis

2001 • 339 citations

Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR–ABL tyrosine kinase

2001 • 332 citations

Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents

2004 • 325 citations

Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase

1998 • 307 citations

Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies.

1992 • 300 citations

Activation-Loop Autophosphorylation Is Mediated by a Novel Transitional Intermediate Form of DYRKs

2005 • 295 citations

The Abl family kinases: Mechanisms of regulation and signaling

2002 • 294 citations

DYRK2 Is Targeted to the Nucleus and Controls p53 via Ser46 Phosphorylation in the Apoptotic Response to DNA Damage

2007 • 283 citations

Regulation of cell death by the Abl tyrosine kinase

2000 • 278 citations

Sequence Characteristics, Subcellular Localization, and Substrate Specificity of DYRK-related Kinases, a Novel Family of Dual Specificity Protein Kinases

1998 • 274 citations

Protein Kinase C δ Is Essential for Etoposide-induced Apoptosis in Salivary Gland Acinar Cells

1999 • 274 citations

Functional interaction between DNA-PK and c-Abl in response to DNA damage

1997 • 254 citations

Phosphorylation sites of protein kinase C δ in H ₂ O ₂ -treated cells and its activation by tyrosine kinase in vitro

2001 • 251 citations

JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage

2005 • 248 citations

Dyrk, a Dual Specificity Protein Kinase with Unique Structural Features Whose Activity Is Dependent on Tyrosine Residues between Subdomains VII and VIII

1996 • 248 citations

Protein kinase Cδ

1999 • 243 citations

Association of the Protein Kinases c-Bcr and Bcr-Abl with Proteins of the 14-3-3 Family

1994 • 233 citations

Nuclear import of PKCδ is required for apoptosis: identification of a novel nuclear import sequence

2002 • 232 citations

PKC-δ is an apoptotic lamin kinase

2000 • 220 citations

Structural and Functional Characteristics of Dyrk, a Novel Subfamily of Protein Kinases with Dual Specificity

1998 • 219 citations

A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region

1996 • 212 citations

Inactivation of DNA-Dependent Protein Kinase by Protein Kinase Cδ: Implications for Apoptosis

1998 • 211 citations

Tumor Promotion by Depleting Cells of Protein Kinase Cδ

1997 • 208 citations

Human Homologs of Schizosaccharomyces pombe Rad1, Hus1, and Rad9 Form a DNA Damage-responsive Protein Complex

1999 • 201 citations

Tyrosine Phosphorylation of Protein Kinase Cδ Is Essential for Its Apoptotic Effect in Response to Etoposide

2002 • 198 citations

Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase

1997 • 191 citations

Subcellular localization of Bcr, Abl, and Bcr-Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation.

1993 • 190 citations

Activation of the Epidermal Growth Factor Receptor Signal Transduction Pathway Stimulates Tyrosine Phosphorylation of Protein Kinase C δ

1996 • 187 citations

Protein Kinase C δ Regulates Ser46 Phosphorylation of p53 Tumor Suppressor in the Apoptotic Response to DNA Damage

2005 • 178 citations

Identification of three additional members of rat protein kinase C family: gd‐, ϵ‐ and ξ‐subspecies

1987 • 173 citations

Isolation of Human and Murine Homologues of theDrosophilaMinibrain Gene: Human Homologue Maps to 21q22.2 in the Down Syndrome “Critical Region”

1996 • 171 citations

Determination of cell fate by c-Abl activation in the response to DNA damage

1998 • 170 citations

Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1A

2001 • 162 citations

Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9

2003 • 154 citations

Activation of protein kinase C δ by the c-Abl tyrosine kinase in response to ionizing radiation

1998 • 148 citations

Protein Kinase C δ Activation and Translocation to the Nucleus Are Required for Fatty Acid-Induced Apoptosis of Insulin-Secreting Cells

2003 • 143 citations

Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1A

2001 • 142 citations

Protein kinase Cδ and apoptosis

2007 • 142 citations

Protein Kinase C δ Regulates Function of the DF3/MUC1 Carcinoma Antigen in β-Catenin Signaling

2002 • 141 citations

Translocation of Protein Kinase Cε and Protein Kinase Cδ to Membrane Is Required for Ultraviolet B-induced Activation of Mitogen-activated Protein Kinases and Apoptosis

1999 • 137 citations

p53AIP1 regulates the mitochondrial apoptotic pathway.

2002 • 125 citations

ATM-dependent Phosphorylation of Human Rad9 Is Required for Ionizing Radiation-induced Checkpoint Activation

2001 • 121 citations

Cloning of a Human Homolog of theDrosophila Minibrain/Rat Dyrk Gene from “the Down Syndrome Critical Region” of Chromosome 21

1996 • 118 citations

BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint

2004 • 115 citations

Crystal structure of the C2 domain from protein kinase C-δ

1998 • 113 citations

Wsh3/Tea4 Is a Novel Cell-End Factor Essential for Bipolar Distribution of Tea1 and Protects Cell Polarity under Environmental Stress in S. pombe

2005 • 112 citations

Protein Kinase C δ Induces Transcription of the TP53 Tumor Suppressor Gene by Controlling Death-Promoting Factor Btf in the Apoptotic Response to DNA Damage

2007 • 106 citations

Structure and properties of a ubiquitously expressed protein kinase C, nPKCδ

1991 • 105 citations

Tumor selective reactivity of a monoclonal antibody prepared against a recombinant peptide derived from the DF3 human breast carcinoma-associated antigen.

1992 • 102 citations

Inhibition of T cell apoptosis by IFN-β rapidly reverses nuclear translocation of protein kinase C-δ

1999 • 101 citations

c-Abl Tyrosine Kinase Regulates the Human Rad9 Checkpoint Protein in Response to DNA Damage

2002 • 99 citations

Induction of Apoptosis Is Driven by Nuclear Retention of Protein Kinase Cδ

2007 • 98 citations

PKCδ signaling: Mechanisms of DNA damage response and apoptosis

2007 • 98 citations

MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage

2006 • 88 citations

Mouse protein kinase C-.delta., the major isoform expressed in mouse hemopoietic cells: sequence of the cDNA, expression patterns, and characterization of the protein

1991 • 85 citations

Activation of SAPK/JNK Signaling by Protein Kinase Cδ in Response to DNA Damage

2002 • 80 citations

Differential selectivity of ligands for the C1a and C1b phorbol ester binding domains of protein kinase Cdelta: possible correlation with tumor-promoting activity.

1998 • 62 citations

Inhibition of Protein Kinase C δ Protects Rat INS-1 Cells Against Interleukin-1β and Streptozotocin-Induced Apoptosis

2002 • 55 citations

Death by Abl: A Matter of Location

2004 • 55 citations

Negative Regulation of the SHPTP1 Protein Tyrosine Phosphatase by Protein Kinase C δ in Response to DNA Damage

2001 • 50 citations

Protein Kinase C δ Activates Topoisomerase IIα To Induce Apoptotic Cell Death in Response to DNA Damage

2006 • 48 citations

MUC1 Oncoprotein Regulates Bcr-Abl Stability and Pathogenesis in Chronic Myelogenous Leukemia Cells

2007 • 44 citations

dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila

2003 • 43 citations

Possible narrowed assignment of the loci of monosomy 21-associated microcephaly and intrauterine growth retardation to a 1.2-Mb segment at 21q22.2.

1997 • 42 citations

Pro-apoptotic effect of the c-Abl tyrosine kinase in the cellular response to 1-β-D-arabinofuranosylcytosine

1997 • 42 citations

Cysteine‐rich regions of protein kinase Cδ are functionally non‐equivalent

1997 • 41 citations

Molecular and biochemical characterization of a recombinant human PKC-δ family member

1993 • 39 citations

Signaling Defect in the Activation of Caspase-3 and PKCδ in Human TUR Leukemia Cells Is Associated with Resistance to Apoptosis

1999 • 33 citations

A novel type of phorbol ester-dependent protein phosphorylation in the particulate fraction of mouse epidermis

1986 • 28 citations

Identification of p53–46F as a super p53 with an enhanced ability to induce p53‐dependent apoptosis

2006 • 28 citations

BRCA1-Mediated Ubiquitination Inhibits Topoisomerase IIαActivity in Response to Oxidative Stress

2007 • 17 citations