DNA Damage to a Single Chromosome End Delays Anaphase Onset

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

2007 • 2,956 citations

A DNA damage checkpoint response in telomere-initiated senescence

2003 • 2,600 citations

Switching and Signaling at the Telomere

2001 • 2,073 citations

How Shelterin Protects Mammalian Telomeres

2008 • 1,730 citations

DNA Damage Foci at Dysfunctional Telomeres

2003 • 1,341 citations

DNA breaks and chromosome pulverization from errors in mitosis

2012 • 1,163 citations

RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

2007 • 1,133 citations

Protection of mammalian telomeres

2002 • 926 citations

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

2009 • 877 citations

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

2012 • 737 citations

Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.

1989 • 733 citations

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

2008 • 550 citations

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

2010 • 512 citations

Frequent chromosomal translocations induced by DNA double-strand breaks

2000 • 498 citations

Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations

2000 • 440 citations

Polo-like kinase-1 is a target of the DNA damage checkpoint

2000 • 437 citations

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

2007 • 436 citations

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

1999 • 397 citations

Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4

2006 • 386 citations

Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells

2012 • 307 citations

Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions

2014 • 305 citations

POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end

2005 • 300 citations

DNA damage signaling in response to double-strand breaks during mitosis

2010 • 293 citations

Functional Human Telomeres Are Recognized as DNA Damage in G2 of the Cell Cycle

2005 • 277 citations

Dynamics of Centromere and Kinetochore Proteins

2004 • 264 citations

Telomeres Do D-Loop–T-Loop

1999 • 258 citations

Chk1 Is Required for Spindle Checkpoint Function

2007 • 230 citations

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

2010 • 223 citations

DNA Damage during Mitosis in Human Cells Delays the Metaphase/Anaphase Transition via the Spindle-Assembly Checkpoint

2002 • 216 citations

Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cells

2009 • 210 citations

In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells.

1993 • 177 citations

POT1 and TRF2 Cooperate To Maintain Telomeric Integrity

2005 • 169 citations

Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage

1999 • 164 citations

A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest

2012 • 154 citations

The Telomere Deprotection Response Is Functionally Distinct from the Genomic DNA Damage Response

2013 • 144 citations

DNA-replication/DNA-damage-dependent centrosome inactivation in Drosophila embryos

2000 • 142 citations

Condensin I Interacts with the PARP-1-XRCC1 Complex and Functions in DNA Single-Strand Break Repair

2006 • 132 citations

Illegitimate recombination induced by DNA double-strand breaks in a mammalian chromosome.

1994 • 117 citations

Dynamics of Centromere and Kinetochore ProteinsImplications for Checkpoint Signaling and Silencing

2004 • 113 citations

DNA lesions sequestered in micronuclei induce a local defective-damage response

2009 • 109 citations

Werner and Bloom helicases are involved in DNA repair in a complementary fashion

2002 • 109 citations

BAL1 and Its Partner E3 Ligase, BBAP, Link Poly(ADP-Ribose) Activation, Ubiquitylation, and Double-Strand DNA Repair Independent of ATM, MDC1, and RNF8

2012 • 104 citations

Inactivation of DNA-Dependent Protein Kinase Leads to Spindle Disruption and Mitotic Catastrophe with Attenuated Checkpoint Protein 2 Phosphorylation in Response to DNA Damage

2010 • 101 citations

53BP1-mediated DNA double strand break repair: Insert bad pun here

2011 • 93 citations

Mad2 Prolongs DNA Damage Checkpoint Arrest Caused by a Double-Strand Break via a Centromere-Dependent Mechanism

2010 • 92 citations

Whole chromosome loss is promoted by telomere dysfunction in primary cells

2010 • 83 citations

ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres

2012 • 82 citations

DNA Damage Activates the SAC in an ATM/ATR-Dependent Manner, Independently of the Kinetochore

2008 • 82 citations

A role for monoubiquitinated FANCD2 at telomeres in ALT cells

2009 • 80 citations

Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair

2011 • 76 citations

The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres

2012 • 73 citations

A role for WRN in telomere-based DNA damage responses

2006 • 63 citations

Interplay between the DNA Damage Proteins MDC1 and ATM in the Regulation of the Spindle Assembly Checkpoint

2014 • 61 citations

Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint

2012 • 61 citations

Impact of Histone H4 Lysine 20 Methylation on 53BP1 Responses to Chromosomal Double Strand Breaks

2012 • 59 citations

Specific local induction of DNA strand breaks by infrared multi-photon absorption

2009 • 54 citations

Use of near infrared femtosecond lasers as sub-micron radiation microbeam for cell DNA damage and repair studies

2010 • 54 citations

Internet‐based robotic laser scissors and tweezers microscopy

2005 • 53 citations

DNA Damage during the Spindle-Assembly Checkpoint Degrades CDC25A, Inhibits Cyclin–CDC2 Complexes, and Reverses Cells to Interphase

2003 • 50 citations

Illegitimate Recombination Induced by DNA Double-Strand Breaks in a Mammalian Chromosome

1994 • 49 citations

Deciphering protein function during mitosis in PtK cells using RNAi

2006 • 48 citations

DNA-PKcs activates the Chk2–Brca1 pathway during mitosis to ensure chromosomal stability

2014 • 47 citations

p53 Prevents Entry into Mitosis with Uncapped Telomeres

2010 • 45 citations

Analysis of DNA double-strand break response and chromatin structure in mitosis using laser microirradiation

2010 • 42 citations

DNA damage leads to a Cyclin A–dependent delay in metaphase-anaphase transition in the Drosophila gastrula

2001 • 39 citations

Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint

2008 • 37 citations

Spatiotemporal dynamics of DNA repair proteins following laser microbeam induced DNA damage – When is a DSB not a DSB?

2013 • 35 citations

CtIP Is Required to Initiate Replication-Dependent Interstrand Crosslink Repair

2012 • 34 citations

Directed Chromosome Loss by Laser Microirradiation

1974 • 33 citations

Highlighting the DNA damage response with ultrashort laser pulses in the near infrared and kinetic modeling

2013 • 30 citations

Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics

2010 • 29 citations

Inhibition of the Mitotic Exit Network in Response to Damaged Telomeres

2013 • 26 citations

CDK1 Regulates Mediator of DNA Damage Checkpoint 1 during Mitotic DNA Damage

2012 • 13 citations

Chromosome Tips Damaged in Anaphase Inhibit Cytokinesis

2010 • 13 citations

Targeting telomere-containing chromosome ends with a near-infrared femtosecond laser to study the activation of the DNA damage response and DNA damage repair pathways

2013 • 7 citations

The Chromosomes of Four Species of Marsupials

1925 • 6 citations