Changes in 7SL RNA conformation during the signal recognition particle cycle.

Protein translocation across the endoplasmic reticulum

1984 • 825 citations

Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.

1981 • 807 citations

Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum

1982 • 766 citations

Intermediate states in the movement of transfer RNA in the ribosome

1989 • 736 citations

[6] Preparation of microsomal membranes for cotranslational protein translocation

1983 • 679 citations

Secretory protein translocation across membranes—the role of the ‘docking protein’

1982 • 648 citations

Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein.

1981 • 644 citations

Alu sequences are processed 7SL RNA genes

1984 • 592 citations

Mechanism of Protein Translocation Across the Endoplasmic Reticulum Membrane

1986 • 509 citations

Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum.

1980 • 502 citations

Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites

1989 • 492 citations

Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor.

1982 • 478 citations

Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle

1989 • 474 citations

Conservation of the primary structure at the 3′ end of 18S rRNA from eucaryotic cells

1978 • 427 citations

Transfer RNA shields specific nucleotides in 16S ribosomal RNA from attack by chemical probes

1986 • 425 citations

Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle.

1982 • 388 citations

Structure and function of mammalian ribosomes

1970 • 380 citations

Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP–binding domains

1989 • 357 citations

Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle.

1986 • 337 citations

The signal sequence of nascent preprolactin interacts with the 54K polypeptide of the signal recognition particle

1986 • 336 citations

An adenovirus E1a protein region required for transformation and transcriptional repression

1986 • 329 citations

An E. coli Ribonucleoprotein Containing 4.5 S RNA Resembles Mammalian Signal Recognition Particle

1990 • 285 citations

Translocation of secretory proteins across the microsomal membrane occurs through an environment accessible to aqueous perturbants

1985 • 277 citations

Slippery Runs, Shifty Stops, Backward Steps, and Forward Hops: -2, -1, +1, +2, +5, and +6 Ribosomal Frameshifting

1987 • 264 citations

Each of the activities of signal recognition particle (SRP) is contained within a distinct domain: Analysis of biochemical mutants of SRP

1988 • 248 citations

Disassembly and reconstitution of signal recognition particle

1983 • 242 citations

The functional role of ribosomal RNA in protein synthesis

1989 • 238 citations

E. coli 4.5S RNA is part of a ribonucleoprotein particle that has properties related to signal recognition particle

1990 • 212 citations

Human 7SL RNA consists of a 140 nucleotide middle-repetitive sequence inserted in an Alu sequence

1982 • 212 citations

The signal recognition particle receptor is a complex that contains two distinct polypeptide chains.

1986 • 189 citations

Translational control of insulin biosynthesis. Evidence for regulation of elongation, initiation and signal-recognition-particle-mediated translational arrest by glucose

1986 • 187 citations

Upstream sequences modulate the internal promoter of the human 7SL RNA gene

1985 • 184 citations

SRP-RNA sequence alignment and secondary structure

1991 • 181 citations

Elongation arrest is not a prerequisite for secretory protein translocation across the microsomal membrane.

1985 • 179 citations

Human SRP RNA and E. coli 4.5S RNA contain a highly homologous structural domain

1988 • 178 citations

Removal of the Alu structural domain from signal recognition particle leaves its protein translocation activity intact

1986 • 176 citations

Transient involvement of signal recognition particle and its receptor in the microsomal membrane prior to protein translocation

1983 • 160 citations

Signal recognition particle mediates a transient elongation arrest of preprolactin in reticulocyte lysate.

1989 • 148 citations

Direct probing of the interaction between the signal sequence of nascent preprolactin and the signal recognition particle by specific cross-linking.

1987 • 119 citations

A bacterial secretory protein requires signal recognition particle for translocation across mammalian endoplasmic reticulum.

1982 • 118 citations

The organization of the 7SL RNA in the signal recognition particle

1983 • 114 citations

Interconversion of active and inactive 30 S ribosomal subunits is accompanied by a conformational change in the decoding region of 16 S rRNA

1986 • 112 citations

Binding sites of the 19-kDa and 68/72-kDa signal recognition particle (SRP) proteins on SRP RNA as determined in protein-RNA "footprinting".

1988 • 112 citations

Structure and evolution of the 7SL RNA component of the signal recognition particle.

1984 • 85 citations

Subcellular distribution of signal recognition particle and 7SL-RNA determined with polypeptide-specific antibodies and complementary DNA probe.

1983 • 77 citations

The secondary structure of the 7SL RNA in the signal recognition particle: functional implications

1985 • 77 citations

Signal recognition particle (SRP) does not mediate a translational arrest of nascent secretory proteins in mammalian cell-free systems.

1985 • 73 citations

Protein translocation across wheat germ microsomal membranes requires an SRP-like component

1987 • 72 citations

The 7S RNA from tomato leaf tissue resembles a signal recognition particle RNA and exhibits a remarkable sequence complementarity to viroids.

1988 • 65 citations

Evidence for an extended 7SL RNA structure in the signal recognition particle.

1987 • 63 citations

Reverse transcriptase pauses at N2-methylguanine during in vitro transcription of Escherichia coli 16S ribosomal RNA.

1979 • 62 citations

Signal recognition particle arrests elongation of nascent secretory and membrane proteins at multiple sites in a transient manner.

1987 • 61 citations

Transfer of Secretory Proteins through the Membrane of the Endoplasmic Reticulum

1986 • 58 citations

Signal recognition-like particles are present in maize.

1988 • 52 citations

Mathematical modeling of the effects of the signal recognition particle on translation and translocation of proteins across the endoplasmic reticulum membrane

1987 • 47 citations

Structure of the signal recognition particle by electron microscopy.

1985 • 45 citations

Signal recognition particle (SRP) stabilizes the translocation-competent conformation of pre-secretory proteins.

1988 • 44 citations

Identification of dynamic sequences in the central domain of 7SL RNA

1986 • 37 citations

Structure and Function of Signal Recognition Particle RNA

1989 • 36 citations

Characterization of the association of two small molecular weight RNAs with eukaryotic polysomes.

1981 • 26 citations

Structural analysis of the peptidyl transferase region in ribosomal RNA of the eukaryote Xenopus laevis

1991 • 22 citations

Two receptors act sequentially

1987 • 20 citations

Low resolution three-dimensional models of the 7SL RNA of the signal recognition particle, based on an intramolecular cross-link introduced by mild irradiation with ultraviolet light

1989 • 17 citations

Signal recognition particle causes a transient arrest in the biosynthesis of prepromelittin and mediates its translocation across mammalian endoplasmic reticulum.

1987 • 9 citations

A 5 S rRNA‐like secondary structure in the 7 SL RNA may define a ribosomal binding site of the signal recognition particle

1987 • 5 citations