Mathematical modeling of the effects of the signal recognition particle on translation and translocation of proteins across the endoplasmic reticulum membrane

Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.

1981 • 807 citations

Secretory protein translocation across membranes—the role of the ‘docking protein’

1982 • 648 citations

Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein.

1981 • 644 citations

Synchronised transmembrane insertion and glycosylation of a nascent membrane protein

1977 • 529 citations

Metabolic regulation and mathematical models

1978 • 491 citations

Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor.

1982 • 478 citations

Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein.

1981 • 414 citations

Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle.

1982 • 388 citations

The signal sequence of nascent preprolactin interacts with the 54K polypeptide of the signal recognition particle

1986 • 336 citations

Concerning the kinetics of polypeptide synthesis on polyribosomes

1969 • 281 citations

Translocation of domains of nascent periplasmic proteins across the cytoplasmic membrane is independent of elongation

1983 • 234 citations

The signal recognition particle receptor is a complex that contains two distinct polypeptide chains.

1986 • 189 citations

Elongation arrest is not a prerequisite for secretory protein translocation across the microsomal membrane.

1985 • 179 citations

Transient involvement of signal recognition particle and its receptor in the microsomal membrane prior to protein translocation

1983 • 160 citations

A kinetic model of protein synthesis. Application to hemoglobin synthesis and translational control.

1979 • 143 citations

Direct probing of the interaction between the signal sequence of nascent preprolactin and the signal recognition particle by specific cross-linking.

1987 • 119 citations

Mathematical modelling of translation of mRNA in eucaryotes; steady states, time-dependent processes and application to reticulocytest

1980 • 98 citations

Quasi-steady-state approximation in the mathematical modeling of biochemical reaction networks

1983 • 97 citations

The erythrocyte anion transport protein is cotranslationally inserted into microsomes

1982 • 92 citations

Protein Translocation Across and Integration into Membrane

1986 • 91 citations

Segregation of mutant ovalbumins and ovalbumin-globin fusion proteins in Xenopus oocytes

1984 • 89 citations

Xenopus oocytes can secrete bacterial β-lactamase

1984 • 79 citations

Signal recognition particle (SRP) does not mediate a translational arrest of nascent secretory proteins in mammalian cell-free systems.

1985 • 73 citations

Translocation of nascent secretory proteins across membranes can occur late in translation.

1986 • 62 citations

Signal recognition particle triggers the translocation of storage globulin polypeptides from field beans (Vicia faba L.) across mammalian endoplasmic reticulum membrane

1984 • 31 citations

COTRANSLATIONAL SEQUESTRATION OF EGG WHITE PROTEINS AND PLACENTAL LACTOGEN INSIDE MEMBRANE VESICLES*

1980 • 22 citations

Internally transposed signal sequence of carp preproinsulin retains its functions with the signal recognition particle

1986 • 8 citations

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