Role of Metabotropic Glutamate Receptor Subtype mGluR1 in Brief Nociception and Central Sensitization of Primate STT Cells

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

1997 • 3,070 citations

The metabotropic glutamate receptors: Structure and functions

1995 • 2,269 citations

Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms

1991 • 942 citations

Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain

1995 • 669 citations

Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons

1991 • 616 citations

Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.

1992 • 597 citations

The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury

1992 • 564 citations

Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia

1991 • 453 citations

Substance P release from spinal cord slices by capsaicin

1979 • 376 citations

The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli

1992 • 370 citations

The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus

1997 • 330 citations

(RS)-2-Chloro-5-Hydroxyphenylglycine (CHPG) Activates mGlu5, but not mGlu1, Receptors Expressed in CHO Cells and Potentiates NMDA Responses in the Hippocampus

1997 • 306 citations

Metabotropic Glutamate Receptors: Novel Targets for Drug Development

1995 • 261 citations

Enhanced responses of spinothalamic tract neurons to excitatory amino acids accompany capsaicin-induced sensitization in the monkey

1992 • 220 citations

Location of cells of origin of spinothalamic tract in lumbar enlargement of the monkey.

1973 • 194 citations

Activation of group I mG1uRs potentiates NMDA responses in rat hippocampal slices

1996 • 179 citations

The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception

1996 • 168 citations

Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn.

1992 • 165 citations

Requirement of Metabotropic Glutamate Receptors for the Generation of Inflammation‐evoked Hyperexcitability in Rat Spinal Cord Neurons

1994 • 162 citations

Expression and Coupling to Polyphosphoinositide Hydrolysis of Group I Metabotropic Glutamate Receptors in Early Postnatal and Adult Rat Brain

1997 • 149 citations

The Metabotropic Glutamate Receptor mGluR5 Induces Calcium Oscillations in Cultured Astrocytes via Protein Kinase C Phosphorylation

1997 • 138 citations

Growth factor upregulation of a phosphoinositide-coupled metabotropic glutamate receptor in cortical astrocytes

1995 • 136 citations

Selective activation of quisqualate metabotropic receptor potentiates NMDA but not AMPA responses

1991 • 135 citations

Regeneration of periodontal primary afferents of the rat incisor following injury of the inferior alveolar nerve with special reference to neuropeptide Y-like immunoreactive primary afferents

1997 • 131 citations

Two Pathways of Cyclic GMP Production Through Glutamate Receptor‐Mediated Nitric Oxide Synthesis

1992 • 130 citations

Neurokinin 1 and 2 antagonists attenuate the responses and NK1 antagonists prevent the sensitization of primate spinothalamic tract neurons after intradermal capsaicin

1994 • 122 citations

Amino acids and serotonin are released into the lumbar spinal cord of the anesthetized cat following intradermal capsaicin injections

1993 • 121 citations

Possible role of protein kinase C in the sensitization of primate spinothalamic tract neurons.

1996 • 119 citations

Acute mechanical hyperalgesia is produced by coactivation of AMPA and metabotropic glutamate receptors

1993 • 109 citations

Evidence for a role of metabotropic glutamate receptors in sustained nociceptive inputs to rat dorsal horn neurons

1994 • 106 citations

Modulation of AMPA and NMDA responses in rat spinal dorsal horn neurons by trans-1-aminocyclopentane-1,3-dicarboxylic acid

1992 • 104 citations

Metabotropic Glutamate Receptors Inhibiting Excitatory Synapses in the CA1 Area of Rat Hippocampus

1995 • 104 citations

Involvement of cGMP in Nociceptive Processing by and Sensitization of Spinothalamic Neurons in Primates

1997 • 101 citations

Comparison of nociceptive effects produced by intrathecal administration of mGluR agonists

1996 • 100 citations

Possible Role of Protein Kinase C in the Sensitization of Primate Spinothalamic Tract Neurons

1996 • 99 citations

Nitric Oxide Mediates the Central Sensitization of Primate Spinothalamic Tract Neurons

1999 • 96 citations

Antisense Ablation of Type I Metabotropic Glutamate Receptor mGluR₁Inhibits Spinal Nociceptive Transmission

1998 • 94 citations

In vivo antinociceptive activity of anti-rat mGluR1 and mGluR5 antibodies in rats

1998 • 92 citations

Epileptogenesis in vivo enhances the sensitivity of inhibitory presynaptic metabotropic glutamate receptors in basolateral amygdala neurons in vitro.

1997 • 90 citations

The involvement of metabotropic glutamate receptors and their intracellular signalling pathways in sustained nociceptive transmission in rat dorsal horn neurons

1995 • 90 citations

Nitric oxide contributes to central sensitization following intradermal injection of capsaicin

1998 • 88 citations

Microdialysis recovery of serotonin released in spinal cord dorsal horn

1988 • 83 citations

Status Epilepticus-Induced Alterations in Metabotropic Glutamate Receptor Expression in Young and Adult Rats

1997 • 81 citations

EpileptogenesisIn VivoEnhances the Sensitivity of Inhibitory Presynaptic Metabotropic Glutamate Receptors in Basolateral Amygdala NeuronsIn Vitro

1997 • 80 citations

Pharmacology of metabotropic glutamate receptor-mediated enhancement of responses to excitatory and inhibitory amino acids on rat spinal neurones in vivo

1995 • 75 citations

Increased spinal release of excitatory amino acids following intradermal injection of capsaicin is reduced by a protein kinase G inhibitor

1998 • 65 citations

Interactions between metabotropic and ionotropic glutamate receptor agonists in the rat spinal cord in vivo

1995 • 59 citations

Inhibitors of G-proteins and protein kinases reduce the sensitization to mechanical stimulation and the desensitization to heat of spinothalamic tract neurons induced by intradermal injection of capsaicin in the primate

1997 • 57 citations

Loss of mGluR-mediated hyperpolarizations and increase in mGluR depolarizations in basolateral amygdala neurons in kindling-induced epilepsy

1996 • 55 citations

Mechanisms underlying developmental changes in the expression of metabotropic glutamate receptors in cultured cerebellar granule cells: homologous desensitization and interactive effects involving N-methyl-D-aspartate receptors.

1993 • 54 citations

Capsaicin-induced sensitization of primate spinothalamic tract cells is prevented by a protein kinase C inhibitor

1997 • 44 citations

Characterization of metabotropic glutamate receptor‐mediated facilitation of N‐methyl‐D‐aspartate depolarization of neocortical neurones

1996 • 38 citations

Chapter 14 Acute mechanical hyperalgesia in the rat can be produced by coactivation of spinal ionotropic AMPA and metabotropic glutamate receptors, activation of phospholipase A2 and generation of cyclooxygenase products

1996 • 32 citations

Pharmacological differentiation of metabotropic glutamate receptors coupled to potentiation of cyclic adenosine monophosphate responses and phosphoinositide hydrolysis.

1993 • 28 citations

Full length article

1997 • 21 citations

Deafferentation up‐regulates the expression of the mGlu1a metabotropic glutamate receptor protein in the olfactory bulb

1998 • 17 citations

Contributions of glutamate receptors to the maintenance of mustard oil-induced hyperalgesia in spinalized rats

1997 • 15 citations

The effects of SDZ NKT 343, a potent NK1 receptor antagonist, on cutaneous responses of primate spinothalamic tract neurones sensitized by intradermal capsaicin injection

1998 • 14 citations