The CD4-gpl20 Interaction and Aids Pathogenesis

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1986 • 2,020 citations

Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy

1986 • 1,694 citations

HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

1989 • 1,574 citations

Structure of a human common cold virus and functional relationship to other picornaviruses

1985 • 1,419 citations

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

Binding of HTLV-III/LAV to T4 ⁺ T Cells by a Complex of the 110K Viral Protein and the T4 Molecule

1986 • 988 citations

Functional Regions of the Envelope Glycoprotein of Human Immunodeficiency Virus Type 1

1987 • 883 citations

Genome organization and transactivation of the human immunodeficiency virus type 2

1987 • 842 citations

A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses

1989 • 825 citations

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity

1986 • 804 citations

In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity

1988 • 754 citations

The Reservoir for HIV-1 in Human Peripheral Blood Is a T Cell That Maintains Expression of CD4

1989 • 732 citations

Biologic Features of HIV-1 That Correlate with Virulence in the Host

1988 • 679 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates

1989 • 662 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex

1988 • 621 citations

pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane

1987 • 620 citations

Designing CD4 immunoadhesins for AIDS therapy

1989 • 612 citations

Major Glycoprotein Antigens That Induce Antibodies in AIDS Patients Are Encoded by HTLV-III

1985 • 583 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

soluble form of CD4 (T4) protein inhibits AIDS virus infection

1988 • 530 citations

Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins

1987 • 517 citations

AIDS Retrovirus Induced Cytopathology: Giant Cell Formation and Involvement of CD4 antigen

1986 • 516 citations

Human immunodeficiency virus type 1 neutralization epitope with conserved architecture elicits early type-specific antibodies in experimentally infected chimpanzees.

1988 • 514 citations

Cell-cell adhesion mediated by CD8 and MHC class I molecules

1988 • 445 citations

Detection of a fusion peptide sequence in the transmembrane protein of human immunodeficiency virus

1987 • 433 citations

Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells

1989 • 405 citations

Alterations in T4 (CD4) Protein and mRNA Synthesis in Cells Infected with HIV

1986 • 360 citations

Induction of tolerance by monoclonal antibody therapy

1986 • 307 citations

Molecular Events Mediating T Cell Activation

1990 • 303 citations

Virus Isolation From and Identification of HTLV-III/LAV-Producing Cells in Brain Tissue From a Patient With AIDS

1986 • 302 citations

Human immunodeficiency virus infection of CD4-bearing cells occurs by a pH-independent mechanism.

1988 • 299 citations

Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4

1988 • 294 citations

The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4

1988 • 277 citations

Single amino-acid changes in HIV envelope affect viral tropism and receptor binding

1989 • 270 citations

Evidence for a physical association of CD4 and the CD3: α : β T-cell receptor

1987 • 265 citations

Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein

1988 • 253 citations

Identification of the Fusion Peptide of Primate Immunodeficiency Viruses

1989 • 250 citations

HIV infection does not require endocytosis of its receptor, CD4

1988 • 228 citations

Highly efficient neutralization of HIV with recombinant CD4-immunoglobulin molecules

1989 • 217 citations

Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4

1988 • 173 citations

A CD4 domain important for HIV-mediated syncytium formation lies outside the virus binding site

1990 • 170 citations

Synthetic CD4 Peptide Derivatives That Inhibit HIV Infection and Cytopathicity

1988 • 164 citations

Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.

1988 • 160 citations

Spectrum of disease in macaque monkeys chronically infected with SIV/SMM

1989 • 158 citations

Structure and expression of the human and mouse T4 genes.

1987 • 155 citations

The MHC-Binding and gp120-Binding Functions of CD4 Are Separable

1989 • 151 citations

The human and simian immunodeficiency viruses HIV-1, HIV-2 and SIV interact with similar epitopes on their cellular receptor, the CD4 molecule

1988 • 144 citations

Humoral immune response to the entire human immunodeficiency virus envelope glycoprotein made in insect cells.

1987 • 138 citations

Enhancement of SIV Infection with Soluble Receptor Molecules

1990 • 136 citations

Synergism Between HIV gp120 and gp120-Specific Antibody in Blocking Human T Cell Activation

1989 • 135 citations

The Safety and Pharmacokinetics of Recombinant Soluble CD4 (rCD4) in Subjects with the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex

1990 • 133 citations

Analysis of the site in CD4 that binds to the HIV envelope glycoprotein.

1990 • 132 citations

Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene

1987 • 127 citations

A soluble recombinant polypeptide comprising the amino-terminal half of the extracellular region of the CD4 molecule contains an active binding site for human immunodeficiency virus.

1988 • 120 citations

Characterization of a Noncytopathic HIV-2 Strain with Unusual Effects on CD4 Expression

1988 • 119 citations

Role of N-linked glycans in the interaction between the envelope glycoprotein of human immunodeficiency virus and its CD4 cellular receptor. Structural enzymatic analysis.

1989 • 113 citations

HIV infection of primate lymphocytes and conservation of the CD4 receptor

1987 • 107 citations

T-cell receptor-CD4 physical association in a murine T-cell hybridoma: induction by antigen receptor ligation.

1989 • 103 citations

Theoretically Determined Three-Dimensional Structures for Amphipathic Segments of the HIV-1 gp41 Envelope Protein

1989 • 91 citations

Induction of immune tolerance during administration of monoclonal antibody to L3T4 does not depend on depletion of L3T4+ cells.

1988 • 84 citations

Expression and Characterization of Human CD4: Immunoglobulin Fusion Proteins

1990 • 73 citations

Coaggregation of the T-cell receptor with CD4 and other T-cell surface molecules enhances T-cell activation.

1987 • 71 citations

Antigen processing and CD4+ T cell depletion in AIDS

1988 • 65 citations

CD4 immunoadhesin, but not recombinant soluble CD4, blocks syncytium formation by human immunodeficiency virus type 2-infected lymphoid cells

1990 • 31 citations

Crystallization of a soluble form of the rat T-cell surface glycoprotein CD4 complexed with Fab from the W3/25 monoclonal antibody

1990 • 29 citations

Effect of recombinant soluble CD4 on human peripheral blood lymphocyte responses in vitro.

1988 • 17 citations

CD4 and p56lck can stably associate when co-expressed in NIH3T3 cells.

1989 • 6 citations