Molecular Genetics in Carcinoma of the Bladder

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene.

1989 • 2,011 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

1990 • 1,882 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

Informativeness of human (dC-dA)n · (dG-dT)n polymorphisms

1990 • 1,371 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Cold Spring Harbor Laboratory

1995 • 1,077 citations

Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC

1988 • 905 citations

Identification of p53 Gene Mutations in Bladder Cancers and Urine Samples

1991 • 891 citations

Cancer statistics, 1990

1990 • 818 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.

1982 • 775 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

1991 • 708 citations

Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

1995 • 653 citations

Suppression of Tumorigenicity of Human Prostate Carcinoma Cells by Replacing a Mutated RB Gene

1990 • 606 citations

Two molecular pathways to transitional cell carcinoma of the bladder.

1994 • 599 citations

Chromosome Aberrations and Cancer

1991 • 598 citations

Nuclear Overexpression of p53 Protein in Transitional Cell Bladder Carcinoma: A Marker for Disease Progression

1993 • 544 citations

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.

1990 • 543 citations

Clonal Origin of Bladder Cancer

1992 • 538 citations

ROLE OF N-ACETYLTRANSFERASE PHENOTYPES IN BLADDER CARCINOGENESIS: A PHARMACOGENETIC EPIDEMIOLOGICAL APPROACH TO BLADDER CANCER

1982 • 501 citations

p53: At the Crossroads of Molecular Carcinogenesis and Risk Sssessment

1993 • 477 citations

p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer.

1993 • 464 citations

Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5.

1989 • 448 citations

Structural Rearrangement of the Retinoblastoma Gene in Human Breast Carcinoma

1988 • 423 citations

Molecular Detection of Primary Bladder Cancer by Microsatellite Analysis

1996 • 396 citations

Altered Expression of the Retinoblastoma Gene Product: Prognostic Indicator in Bladder Cancer

1992 • 348 citations

Allelic losses of chromosomes 9, 11, and 17 in human bladder cancer.

1990 • 327 citations

Homozygous deletions within human chromosome band 9p21 in melanoma.

1992 • 319 citations

p53 and DNA polymerase α compete for binding to SV40 T antigen

1987 • 291 citations

Allelotype of human bladder cancer.

1994 • 265 citations

Frequent association of p53 gene mutation in Invasive bladder cancer

1992 • 265 citations

Over‐expression of p53 nuclear oncoprotein in transitional‐cell bladder cancer and its prognostic value

1993 • 264 citations

Altered Expression of Retinoblastoma Protein and Known Prognostic Variables in Locally Advanced Bladder Cancer

1992 • 254 citations

Allelic loss of chromosome 17p distinguishes high grade from low grade transitional cell carcinomas of the bladder.

1990 • 252 citations

Maintenance of p53 alterations throughout breast cancer progression.

1991 • 244 citations

Genetic alterations in bladder cancer

1993 • 243 citations

Numerical chromosome 1, 7, 9, and 11 aberrations in bladder cancer detected by in situ hybridization.

1991 • 233 citations

Molecular genetic alterations in superficial and locally advanced human bladder cancer.

1991 • 233 citations

Metachronous multifocal development of urothelial cancers by intraluminal seeding

1993 • 223 citations

Deletions of Interferon Genes in Acute Lymphoblastic Leukemia

1990 • 221 citations

Diagnosis and Management of Genitourinary Cancer

1988 • 208 citations

Molecular analysis of deletions of the short arm of chromosome 9 in human gliomas.

1992 • 187 citations

Microsatellite instability in bladder cancer.

1993 • 187 citations

Deletion of the p16 and p15 Genes in Human Bladder Tumors

1995 • 185 citations

Inactivation of the retinoblastoma gene in human bladder and renal cell carcinomas.

1991 • 184 citations

Expression of mutant p53, c-erbB-2 and the epidermal growth factor receptor in transitional cell carcinoma of the human urinary bladder

1991 • 181 citations

p16 (CDKN2) is a major deletion target at 9p21 in bladder cancer

1995 • 178 citations

Loss of heterozygosity at the RB locus is frequent and correlates with muscle invasion in bladder carcinoma.

1991 • 177 citations

ras Oncogene p21 expression is increased in premalignant lesions and high grade bladder carcinoma.

1985 • 173 citations

Nonrandom chromosomal changes in transitional cell carcinoma of the bladder.

1984 • 172 citations

Construction of a GT polymorphism map of human 9q

1992 • 171 citations

Review of Chromosome Studies in Urological Tumors. II. Cytogenetics and Molecular Genetics of Bladder Cancer

1994 • 171 citations

Role of chromosome 9 in human bladder cancer.

1993 • 166 citations

Deletion mapping of chromosome 8 in cancers of the urinary bladder using restriction fragment length polymorphisms and microsatellite polymorphisms.

1993 • 165 citations

Homozygous deletions of 9p21 in primary human bladder tumors detected by comparative multiplex polymerase chain reaction.

1994 • 164 citations

Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the RB locus and tumor progression

1993 • 159 citations

Progressing toward a molecular description of colorectal cancer development

1992 • 148 citations

Chromosome 9 allelic losses and microsatellite alterations in human bladder tumors.

1994 • 147 citations

Evidence for two bladder cancer suppressor loci on human chromosome 9.

1993 • 143 citations

p53 immunohistochemistry as an independent prognostic factor for superficial transitional cell carcinoma of the bladder

1995 • 142 citations

Increased p16 levels correlate with pRb alterations in human urothelial cells.

1995 • 120 citations

Partial allelotype of carcinoma in situ of the human bladder.

1995 • 116 citations

Influence of cigarette smoking and schistosomiasis on p53 gene mutation in urothelial cancer.

1993 • 115 citations

Accumulated allelic losses in the development of invasive urothelial cancer

1993 • 115 citations

Detailed deletion mapping of chromosome 9q in bladder cancer: evidence for two tumour suppressor loci.

1995 • 108 citations

Novel suppressor loci on chromosome 14q in primary bladder cancer.

1995 • 108 citations

Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations.

1996 • 108 citations

Preliminary mapping of the deleted region of chromosome 9 in bladder cancer.

1993 • 104 citations

Definition of two regions of deletion on chromosome 9 in carcinoma of the bladder.

1994 • 104 citations

Bladder cancer in relation to cigarette smoking.

1988 • 104 citations

p53 immunohistochemistry in transitional cell carcinoma and dysplasia of the urinary bladder correlates with disease progression

1993 • 94 citations

Molecular Genetic Alterations of Chromosome 17 and p53 Nuclear Overexpression in Human Bladder Cancer

1993 • 94 citations

Retinoblastoma gene mutations in primary human bladder cancer

1995 • 88 citations

Human bladder carcinoma cell lines as indicators of oncogenic change relevant to urothelial neoplastic progression

1995 • 88 citations

Homozygous deletions within chromosomal bands 9p21-22 in bladder cancer.

1994 • 87 citations

Loss of heterozygosity on chromosome 18q is associated with muscle-invasive transitional cell carcinoma of the bladder

1994 • 75 citations

Tumor behavior in transitional cell carcinoma of the bladder in relation to chromosomal markers and histopathology.

1987 • 75 citations

High Frequency of Chromosome 9p Allelic Loss and CDKN2 Tumor Suppressor Gene Alterations in Squamous Cell Carcinoma of the Bladder

1995 • 74 citations

Pathways of development and progression in bladder cancer: new correlations between clinical observations and molecular mechanisms.

1993 • 72 citations

Mosaicism in Human Epithelium: Macroscopic Monoclonal Patches Cover the Urothelium

1995 • 71 citations

Characterization of chromosome 9 deletions in transitional cell carcinoma by microsatellite assay

1993 • 65 citations

Mutational spectrum in the p53 gene in bladder tumors from the endemic area of black foot disease in Taiwan

1994 • 64 citations

Homozygous deletion mapping at 9p21 in bladder carcinoma defines a critical region within 2cM of IFNA.

1994 • 61 citations

Expression of c-erbB-2 protein product in bladder cancer

1990 • 53 citations

Detection of the c‐myc Gene Product in Urinary Bladder Cancer

1990 • 52 citations

Nonrandom chromosome losses in stepwise neoplastic transformation in vitro of human uroepithelial cells.

1991 • 52 citations

Elevated expression of pp60c-src in low grade human bladder carcinoma.

1992 • 52 citations

p53 and Rb Immunostaining in Locally Advanced Bladder Cancer: Relation to Prognostic Variables and Predictive Value for the Local Response to Radical Radiotherapy

1995 • 50 citations

Prevalence of RAS oncogene mutation in head and neck carcinomas.

1992 • 42 citations

Chromosome changes in early bladder neoplasms

1992 • 33 citations

Loss of cyclin-dependent kinase inhibitor genes and chromosome 9 karyotypic abnormalities in human bladder cancer cell lines

1995 • 29 citations

Infrequent Somatic Mutation of the MTS1 Gene in Primary Bladder Carcinomas

1995 • 20 citations

Techniques in Cancer Cytogenetics: An Overview and Update

1992 • 10 citations

Radioactive Bullets Raise Cancer Fears

1993 • 5 citations

Basic research in urological oncology

1996 • 5 citations

The Molecular Progression of Bladder Cancer

2015 • 1 citations