Insulin-induced loss of the insulin receptor in IM-9 lymphocytes. A biological process mediated through the insulin receptor.

Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity

1962 • 6,970 citations

The Syndromes of Insulin Resistance and Acanthosis Nigricans

1976 • 1,086 citations

Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

1974 • 1,037 citations

Insulin interactions with its receptors: Experimental evidence for negative cooperativity

1973 • 717 citations

Control of Enzyme Levels in Animal Tissues

1970 • 680 citations

Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

1976 • 601 citations

Regulation of the activity of the low density lipoprotein receptor in human fibroblasts

1975 • 477 citations

Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting.

1976 • 415 citations

Insulin-Receptor Interaction in the Obese-Hyperglycemic Mouse

1973 • 408 citations

Granulosa Cell Maturation in the Rat: Increased Binding of Human Chorionic Gonadotropin Following Treatment with Follicle-Stimulating Hormonein Vivo¹¹

1974 • 398 citations

Insulin Interactions with Liver Plasma Membranes

1972 • 396 citations

Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites.

1975 • 381 citations

Cooperativity in ligand binding: A new graphic analysis

1975 • 369 citations

Regulation of receptor concentration by homologous hormone. Effect of human growth hormone on its receptor in IM-9 lymphocytes.

1976 • 364 citations

Mechanisms Regulating the Concentration and the Conformation of Progesterone Receptor(s) in the Uterus

1973 • 361 citations

Decreased insulin binding to adipocytes and circulating monocytes from obese subjects.

1976 • 342 citations

Characteristics of the Human Lymphocyte Insulin Receptor

1973 • 320 citations

Thyrotropin-releasing hormone regulates the number of its own receptors in the GH3 strain of pituitary cells in culture

1975 • 300 citations

The Insulin Receptor: Its Role in Insulin Resistance of Obesity and Diabetes

1976 • 289 citations

Peptide hormone binding to receptors: A review of direct studies in vitro

1973 • 286 citations

Human Growth Hormone Radioreceptor Assay using Cultured Human Lymphocytes

1973 • 286 citations

Rapid changes in rat pineal beta-adrenergic receptor: alterations in l-(3H)alprenolol binding and adenylate cyclase.

1975 • 265 citations

Insulin Receptor Deficiency in Genetic and Acquired Obesity

1975 • 262 citations

Alterations in Insulin Binding Induced by Changes in Vivo in the Levels of Glucocorticoids and Growth Hormone*

1978 • 246 citations

Insulin Receptors in Human Circulating Cells and Fibroblasts

1972 • 228 citations

Defect in insulin binding to receptors in obese man. Amelioration with calorie restriction.

1975 • 226 citations

Regulation of luteinizing hormone receptors in testicular interstitial cells by gonadotropin

1976 • 225 citations

Gonadotropin-induced loss of hormone receptors and desensitization of adenylate cyclase in the ovary.

1976 • 208 citations

Uterine receptor for oxytocin: Effects of estrogen

1975 • 189 citations

Down Regulation of Insulin Receptors in Primary Cultures of Adult Rat Hepatocytes in Monolayer*

1978 • 178 citations

Cooperative properties of hormone receptors in cell membranes

1976 • 170 citations

Insulin binding to liver plasm membranes in the obese hyperglycemic (ob/ob) mouse. Demonstration of a decreased number of functionally normal receptors.

1975 • 152 citations

The effects of acute and chronic dexamethasone administration on insulin binding to isolated rat hepatocytes and adipocytes

1975 • 150 citations

Correlation between insulin receptor binding in isolated fat cells and insulin sensitivity in obese human subjects.

1976 • 147 citations

Culture of human leukemia cells

1966 • 146 citations

Decreased Insulin Binding to Lymphocytes from Diabetic Subjects

1974 • 144 citations

Intracellular polypeptide hormone receptors. Characterization of insulin binding sites in Golgi fractions from the liver of female rats.

1978 • 123 citations

Interactions of polypeptide hormones with cell membrane specific receptors: Studies with insulin and glucagon

1976 • 122 citations

Insulin receptors in normal and transformed fibroblasts: relationship to growth and transformation

1976 • 117 citations

Insulin receptor defect in insulin resistance: Studies in the obese-hyperglycemic mouse

1972 • 105 citations

Thymic Lymphocytes in Obese (ob/ob) Mice

1974 • 104 citations

Synthesis and turnover of DNA-bound histone during maturation of avian red blood cells

1972 • 94 citations

Stoichiometric binding and regulation of insulin receptors on human diploid fibroblasts using physiologic insulin levels.

1979 • 93 citations

Dna synthesis in purified populations of avian erythroid cells

1972 • 83 citations

Hormonal control of oestrogen receptor in uterus and receptivity for ovoimplantation in the rat

1974 • 78 citations

INSULIN RECEPTORS IN PATIENTS WITH INSULINOMAS: CHANGES IN RECEPTOR AFFINITY AND CONCENTRATION

1977 • 62 citations

The insulin receptor of the turkey erythrocyte characterization of the membrane-bound receptor

1976 • 55 citations

Cyclic AMP increases the concentration of insulin receptors in cultured fibroblasts and lymphocytes

1977 • 50 citations

Insulin-induced reduction of membrane receptor concentrations in isolated fat cells and lymphocytes. Independence from receptor occupation and possible relation to proteolytic activity of insulin.

1975 • 45 citations

Differentiation of ob 17 preadipocytes to adipocytes. Effect of insulin on the levels of insulin receptors and on the transport of alpha-aminoisobutyrate.

1979 • 41 citations