Functional analysis of an isolated fos promoter element with AP-1 site homology reveals cell type-specific transcriptional properties.

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1987 • 1,364 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

1989 • 1,046 citations

Cyclic AMP and the induction of eukaryotic gene transcription.

1988 • 1,041 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.

1984 • 889 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences

1985 • 871 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.

1988 • 736 citations

PC12 Pheochromocytoma Cultures in Neurobiological Research

1982 • 728 citations

Transcription activation by the adenovirus E1a protein

1989 • 667 citations

Transcriptional autoregulation of the proto-oncogene fos

1988 • 630 citations

Regulation of Proenkephalin by Fos and Jun

1989 • 546 citations

Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression.

1986 • 516 citations

ADENOVIRUS PROMOTERS AND E1A TRANSACTIVATION

1986 • 460 citations

Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription

1984 • 458 citations

Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences.

1988 • 404 citations

Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses

1979 • 395 citations

Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.

1988 • 391 citations

Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters

1987 • 379 citations

Adenovirus E1a proteins repress transcription from the SV40 early promoter

1985 • 366 citations

Multiple functional domains in the adenovirus E1A gene

1987 • 361 citations

Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction

1989 • 346 citations

Inducible binding of a factor to the c-fos enhancer

1986 • 310 citations

c-fos Sequence Necessary for Basal Expression and Induction by Epidermal Growth Factor, 12-O-Tetradecanoyl Phorbol-13-Acetate and the Calcium Ionophore

1987 • 304 citations

Interaction of a common cellular transcription factor, ATF, with regulatory elements in both E1a- and cyclic AMP-inducible promoters.

1988 • 290 citations

The SV40 enhancer contains two distinct levels of organization

1988 • 286 citations

A cellular protein, activating transcription factor, activates transcription of multiple E1A-inducible adenovirus early promoters.

1987 • 284 citations

A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1.

1988 • 259 citations

Nerve growth factor regulates tyrosine hydroxylase gene transcription through a nucleoprotein complex that contains c-Fos.

1990 • 247 citations

The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP.

1988 • 245 citations

Transcription factors: a new family gathers at the cAMP response site

1990 • 244 citations

Mutation of the c-fos gene dyad symmetry element inhibits serum inducibility of transcription in vivo and the nuclear regulatory factor binding in vitro.

1987 • 238 citations

Cooperativity and hierarchical levels of functional organization in the SV40 enhancer

1988 • 238 citations

Multiple sequence elements in the c-fos promoter mediate induction by cAMP.

1989 • 225 citations

Repression of the Immunoglobulin Heavy Chain Enhancer by the Adenovirus-2 E1A Products

1985 • 223 citations

Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter.

1989 • 220 citations

Autoregulation of fos: the dyad symmetry element as the major target of repression.

1989 • 211 citations

Cyclic AMP and phorbol ester-stimulated transcription mediated by similar DNA elements that bind distinct proteins.

1988 • 198 citations

Identification of factors that interact with the E1A-inducible adenovirus E3 promoter.

1987 • 189 citations

Adenovirus E1A products suppress myogenic differentiation and inhibit transcription from muscle-specific promoters

1988 • 183 citations

Repression of c-fos transcription is mediated through p67SRF bound to the SRE.

1989 • 182 citations

Two different factors bind to the alpha-domain of the polyoma virus enhancer, one of which also interacts with the SV40 and c-fos enhancers.

1987 • 179 citations

cis-acting elements of the rat growth hormone gene which mediate basal and regulated expression by thyroid hormone.

1987 • 159 citations

A common trans-acting factor is involved in transcriptional regulation of neurotransmitter genes by cyclic AMP.

1988 • 145 citations

The Fos and Jun/AP-1 proteins are involved in the downregulation of Fos transcription.

1989 • 135 citations

Cyclic AMP induction of early adenovirus promoters involves sequences required for E1A trans-activation.

1988 • 128 citations

An AP1-binding site in the c-fos gene can mediate induction by epidermal growth factor and 12-O-tetradecanoyl phorbol-13-acetate.

1989 • 127 citations

Clonal variants of PC12 pheochromocytoma cells with defects in cAMP-dependent protein kinases induce ornithine decarboxylase in response to nerve growth factor but not to adenosine agonists.

1985 • 113 citations

Phosphorylation-dependent activation of the adenovirus-inducible E2F transcription factor in a cell-free system.

1989 • 107 citations

DNA-binding activity of the adenovirus-induced E4F transcription factor is regulated by phosphorylation.

1989 • 104 citations

A mutated polyoma virus enhancer which is active in undifferentiated embryonal carcinoma cells is not repressed by adenovirus-2 E1A products

1986 • 104 citations

Repression of insulin gene expression by adenovirus type 5 E1a proteins.

1987 • 90 citations

General repression of enhanson activity by the adenovirus-2 E1A proteins.

1990 • 83 citations

Induction of transcription factor AP-1 by adenovirus E1A protein and cAMP.

1989 • 69 citations

cAMP acts in synergy with E1A protein to activate transcription of the adenovirus early genes E4 and E1A.

1988 • 66 citations

Functions of adenovirus E1A.

1986 • 66 citations

Adenovirus E1a Proteins Repress Expression from Polyomavirus Early and Late Promoters

1986 • 54 citations

Adenovirus E1a ras cooperation activity is separate from its positive and negative transcription regulatory functions.

1988 • 53 citations

Transcription activation by serum, PDGF, and TPA through the c-fos DSE: cell type specific requirements for induction.

1989 • 50 citations

The structure and functions of the adenovirus early region 1 proteins

1987 • 44 citations

Distinguishable promoter elements are involved in transcriptional activation by E1a and cyclic AMP.

1989 • 42 citations

Repression of Insulin Gene Expression by Adenovirus Type 5 Ela Proteins

1987 • 37 citations

Notes: Insulin Gene Enhancer Activity Is Inhibited by Adenovirus 5 E1a Gene Products

1989 • 27 citations

Altered Transcriptional Activity of c-fos Promoter Plasmids in v-raf-Transformed NIH 3T3 Cells

1990 • 21 citations

Independent cyclic AMP and E1A induction of adenovirus early region 4 expression

1989 • 17 citations

The adenovirus-5 12S E1a protein, but not the 13S induces expression of the endoA differentiation marker in F9 cells.

1989 • 14 citations

The c-fos cyclic AMP-responsive element conveys constitutive expression to a tissue-specific promoter.

1990 • 13 citations

Altered transcriptional activity of c-fos promoter plasmids in v-raf-transformed NIH 3T3 cells.

1990 • 12 citations

Gene Regulation by Growth Factors

1988 • 8 citations