Altered Transcriptional Activity of c-fos Promoter Plasmids in v-raf-Transformed NIH 3T3 Cells

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences

1985 • 871 citations

Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.

1988 • 736 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Transcriptional autoregulation of the proto-oncogene fos

1988 • 630 citations

Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression.

1986 • 516 citations

Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor

1989 • 513 citations

Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus.

1983 • 485 citations

Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.

1988 • 458 citations

Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences.

1988 • 404 citations

c-fos Sequence Necessary for Basal Expression and Induction by Epidermal Growth Factor, 12-O-Tetradecanoyl Phorbol-13-Acetate and the Calcium Ionophore

1987 • 304 citations

The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP.

1988 • 245 citations

Definition of the human raf amino-terminal regulatory region by deletion mutagenesis.

1989 • 240 citations

Mutation of the c-fos gene dyad symmetry element inhibits serum inducibility of transcription in vivo and the nuclear regulatory factor binding in vitro.

1987 • 238 citations

Multiple sequence elements in the c-fos promoter mediate induction by cAMP.

1989 • 225 citations

Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter.

1989 • 220 citations

Autoregulation of fos: the dyad symmetry element as the major target of repression.

1989 • 211 citations

Structure and biological activity of human homologs of the raf/mil oncogene.

1985 • 203 citations

Recombinant fragment assay for gene targetting based on the polymerase chain reaction

1988 • 192 citations

Repression of c-fos transcription is mediated through p67SRF bound to the SRE.

1989 • 182 citations

Transforming but not immortalizing oncogenes activate the transcription factor PEA1.

1988 • 160 citations

The inner core of the serum response element mediates both the rapid induction and subsequent repression of c-fos transcription following serum stimulation.

1990 • 146 citations

Transactivation of c-fos and β-actin genes by raf as a step in early response to transmembrane signals

1990 • 138 citations

raf Family Serine/Threonine Protein Kinases in Mitogen Signal Transduction

1988 • 124 citations

Constitutive synthesis of activator protein 1 transcription factor after viral transformation of mouse fibroblasts.

1988 • 103 citations

Expression of raf oncogenes activates the PEA1 transcription factor motif.

1989 • 101 citations

Expression of c-fos in NIH3T3 cells is very low but inducible throughout the cell cycle.

1986 • 97 citations

Mutation of the c-fos Gene Dyad Symmetry Element Inhibits Serum Inducibility of Transcription In Vivo and the Nuclear Regulatory Factor Binding In Vitro

1987 • 72 citations

Activation of the Serum Response Element and 12-O-Tetradecanoylphorbol-13-Acetate Response Element by the Activated c-raf-1 Protein in a Manner Independent of Protein Kinase C

1989 • 71 citations

Definition of the Human raf Amino-Terminal Regulatory Region by Deletion Mutagenesis

1989 • 50 citations

Transcription activation by serum, PDGF, and TPA through the c-fos DSE: cell type specific requirements for induction.

1989 • 50 citations

Transformation by raf and myc oncogenes.

1986 • 26 citations

Stable Transfer and Restricted Expression of a Cloned Class I Gene Encoding a Secreted Transplantation-Like Antigen

1985 • 12 citations

Structure and Biological Activity of Human Homologs of the raf/mil Oncogene

1985 • 11 citations