Intrinsic Capacities of Molecular Sensors of the Unfolded Protein Response to Sense Alternate Forms of Endoplasmic Reticulum Stress

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1999 • 3,119 citations

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

2003 • 3,079 citations

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

2000 • 3,071 citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 • 2,702 citations

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

2000 • 2,696 citations

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1999 • 2,237 citations

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

2003 • 1,979 citations

Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress

1999 • 1,954 citations

Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

2000 • 1,933 citations

ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

2000 • 1,764 citations

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

2004 • 1,543 citations

ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals

2002 • 1,368 citations

A trip to the ER: coping with stress

2003 • 1,330 citations

Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

2001 • 1,329 citations

Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus.

1996 • 1,306 citations

Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

2001 • 1,283 citations

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

1993 • 1,197 citations

ERAD: the long road to destruction

2005 • 1,188 citations

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

2002 • 1,031 citations

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

1994 • 994 citations

ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to thecis-Acting Element Responsible for the Mammalian Unfolded Protein Response

2000 • 921 citations

Tripartite Management of Unfolded Proteins in the Endoplasmic Reticulum

2000 • 917 citations

Transcriptional and Translational Control in the Mammalian Unfolded Protein Response

2002 • 909 citations

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

1998 • 888 citations

The Transmembrane Kinase Ire1p Is a Site-Specific Endonuclease That Initiates mRNA Splicing in the Unfolded Protein Response

1997 • 886 citations

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

2003 • 843 citations

Signal Sequence Recognition and Protein Targeting to the Endoplasmic Reticulum Membrane

1994 • 821 citations

A transmembrane protein with a cdc2+CDC28-related kinase activity is required for signaling from the ER to the nucleus

1993 • 814 citations

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1998 • 782 citations

Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

2001 • 772 citations

Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control

1998 • 763 citations

Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development

2001 • 693 citations

A Time-Dependent Phase Shift in the Mammalian Unfolded Protein Response

2003 • 670 citations

The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and the Function and Viability of the Pancreas

2002 • 584 citations

On the mechanism of sensing unfolded protein in the endoplasmic reticulum

2005 • 561 citations

Sterol-Regulated Release of SREBP-2 from Cell Membranes Requires Two Sequential Cleavages, One Within a Transmembrane Segment

1996 • 515 citations

Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response

2002 • 508 citations

Structural organization of the endoplasmic reticulum

2002 • 507 citations

Ligand-independent Dimerization Activates the Stress Response Kinases IRE1 and PERK in the Lumen of the Endoplasmic Reticulum

2000 • 408 citations

Sequential Waves of Functionally Related Proteins Are Expressed When B Cells Prepare for Antibody Secretion

2003 • 351 citations

ATF6 as a Transcription Activator of the Endoplasmic Reticulum Stress Element: Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1

2000 • 345 citations

Dissociation of Kar2p/BiP from an ER Sensory Molecule, Ire1p, Triggers the Unfolded Protein Response in Yeast

2000 • 302 citations

The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis

2005 • 302 citations

Activation of an Unfolded Protein Response during Differentiation of Antibody-secreting B Cells

2002 • 297 citations

The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis

2005 • 280 citations

A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1

2004 • 271 citations

Genetic Interactions Due to Constitutive and Inducible Gene Regulation Mediated by the Unfolded Protein Response in C. elegans

2005 • 248 citations

Dimerization and Release of Molecular Chaperone Inhibition Facilitate Activation of Eukaryotic Initiation Factor-2 Kinase in Response to Endoplasmic Reticulum Stress

2002 • 245 citations

Bypassing a Kinase Activity with an ATP-Competitive Drug

2003 • 234 citations

Underglycosylation of ATF6 as a Novel Sensing Mechanism for Activation of the Unfolded Protein Response

2004 • 175 citations

Opposing Roles for ATF6α and ATF6β in Endoplasmic Reticulum Stress Response Gene Induction

2004 • 136 citations

The Protein Kinase/Endoribonuclease IRE1α That Signals the Unfolded Protein Response Has a Luminal N-terminal Ligand-independent Dimerization Domain

2002 • 122 citations

MHC Restriction in Three Dimensions: A View of T Cell Receptor/Ligand Interactions

1997 • 104 citations

Protein translocation across the endoplasmic reticulum: A tunnel with toll booths at entry and exit

1993 • 91 citations

Dimerization Is Required for Activation of eIF2 Kinase Gcn2 in Response to Diverse Environmental Stress Conditions

2004 • 79 citations

Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nuclease.

2004 • 72 citations

Coordination of ATF6-mediated Transcription and ATF6 Degradation by a Domain That Is Shared with the Viral Transcription Factor, VP16

2002 • 68 citations

Search and Destroy: ER Quality Control and ER-Associated Protein Degradation

2005 • 59 citations

The Unfolded Protein Response in marginal zone and follicular zone B cells

2003 • 2 citations