An In Vitro Human Cell-Based Assay to Rank the Relative Immunogenicity of Proteins

Pure Red-Cell Aplasia and Antierythropoietin Antibodies in Patients Treated with Recombinant Erythropoietin

2002 • 1,221 citations

CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells.

1996 • 1,105 citations

Identification of a Brazil-Nut Allergen in Transgenic Soybeans

1996 • 672 citations

Thrombocytopenia caused by the development of antibodies to thrombopoietin

2001 • 670 citations

PRISMS-4: Long-term efficacy of interferon-beta-1a in relapsing MS

2001 • 471 citations

Protein aggregates seem to play a key role among the parameters influencing the antigenicity of interferon alpha (IFN-alpha) in normal and transgenic mice.

1997 • 294 citations

Immune Responses to Therapeutic Proteins in Humans - Clinical Significance, Assessment and Prediction

2002 • 253 citations

Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor

2002 • 244 citations

Bioinformatic Methods for Allergenicity Assessment Using a Comprehensive Allergen Database

2002 • 194 citations

HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis.

1996 • 192 citations

Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2

2000 • 190 citations

Multi-pin peptide synthesis strategy for T cell determinant analysis

1990 • 174 citations

Influenza Virus–induced Dendritic Cell Maturation Is Associated with the Induction of Strong T Cell Immunity to a Coadministered, Normally Nonimmunogenic Protein

2003 • 169 citations

HLA-DQ Determines the Response to Exogenous Wheat Proteins: A Model of Gluten Sensitivity in Transgenic Knockout Mice

2002 • 144 citations

Direct evidence of homology between human DC-1 antigen and murine I-A molecules

1982 • 144 citations

Design and selection of vaccine adjuvants: animal models and human trials

2002 • 121 citations

Occupational asthma and allergy associated with the use of enzymes in the detergent industry–a review of the epidemiology, toxicology and methods of prevention

2000 • 116 citations

Immune responses in farm workers after exposure to Bacillus thuringiensis pesticides.

1999 • 110 citations

Clinical and immunological responses to enzymes of Bacillus subtilis in factory workers and consumers

1973 • 105 citations

Factors influencing the development of an anti–factor IX (FIX) immune response following administration of adeno-associated virus–FIX

2001 • 86 citations

The proteolytic activity of the major dust mite allergen Der p 1 enhances the IgE antibody response to a bystander antigen

2001 • 84 citations

Respiratory Allergenicity of Detergent Enzymes in the Guinea Pig Intratracheal Test: Association with Sensitization of Occupationally Exposed Individuals

1997 • 63 citations

Peanut and tree nut allergy

2000 • 60 citations

Risk of enzyme allergy in the detergent industry

2000 • 60 citations

The paradox of MHC-DRB exon/intron evolution: ?-helix and ?-sheet encoding regions diverge while hypervariable intronic simple repeats coevolve with ?-sheet codons

1993 • 57 citations

HLA class II transgenic mice: models of the human CD4⁺ T‐cell immune response

1999 • 57 citations

Relationship between kinetic stability and immunogenicity of HLA-DR4/peptide complexes

2002 • 53 citations

Neutralizing and Binding Antibodies to IFN-β: Relative Frequency in Relapsing-Remitting Multiple Sclerosis Patients Treated with Different IFN-βPreparations

2002 • 53 citations

Occupational asthma and allergy in the detergent industry: new developments

2002 • 44 citations

Identification of Respiratory Allergens,

1996 • 43 citations

Use of the Mouse Intranasal Test (MINT) to Determine the Allergenic Potency of Detergent Enzymes: Comparison to the Guinea Pig Intratracheal (GPIT) Test

1998 • 39 citations

Sensitization to industrial enzymes in enzyme research and production

1997 • 39 citations

Constitutive presentation of dominant epitopes from endogenous naturally processed self-beta 2-microglobulin to class II-restricted T cells leads to self-tolerance.

1995 • 38 citations

Identification of Respiratory Allergens

1996 • 35 citations

Constraints in antigen processing result in unresponsiveness to a T cell epitope of hen egg lysozyme in C57BL/6 mice

1992 • 34 citations

A longitudinal study of possible allergy to enzyme detergents

1985 • 34 citations

Transgenic models of autoimmune disease

2002 • 33 citations

An overview of scientific and regulatory issues for the immunogenicity of biological products.

2003 • 30 citations

A 320-Kilobase Artificial Chromosome Encoding the Human HLA DR3-DQ2 MHC Haplotype Confers HLA Restriction in Transgenic Mice

2002 • 29 citations

Identification of T Cell Determinants on Human Type II Collagen Recognized by HLA-DQ8 and HLA-DQ6 Transgenic Mice

1999 • 28 citations

Characterization of HLA DR3/DQ2 transgenic mice: a potential humanized animal model for autoimmune disease studies

2002 • 28 citations

CD4+ T-Cell Epitope Determination Using Unexposed Human Donor Peripheral Blood Mononuclear Cells

2000 • 26 citations

HLA transgenic mice as models of human autoimmune diseases.

2000 • 25 citations

Sensitisation to enzymes in the animal feed industry

2001 • 24 citations

A human dendritic cell-based method to identify CD4+ T-cell epitopes in potential protein allergens.

2003 • 19 citations

Food allergy—towards predictive testing for novel foods

2001 • 18 citations

Human population-based identification of CD4+ T-cell peptide epitope determinants

2003 • 18 citations

Animal models as indicators of immunogenicity of therapeutic proteins in humans.

2003 • 15 citations

Experience with a Mouse Intranasal Test for the Predictive Identification of Respiratory Sensitization Potential of Proteins

1999 • 13 citations

CD4⁺ T cell epitope identification: applications to allergy

2003 • 9 citations

Strain Variation in the IgG1 Antibody Response to Proteins Administered Intranasally in the Mouse

1999 • 9 citations

Antigenicity of mouse monoclonal antibodies. A study on the variable region of the heavy chain

1991 • 5 citations

Cryptic determinants and promiscuous sequences on human acetylcholine receptor: HLA-dependent dichotomy in T-cell function

2002 • 5 citations

Enhanced immunogenicity of a functional enzyme by T cell epitope modification.

2002 • 5 citations