Protein aggregates seem to play a key role among the parameters influencing the antigenicity of interferon alpha (IFN-alpha) in normal and transgenic mice.

Cold Spring Harbor Laboratory

1995 • 1,077 citations

Stability of protein pharmaceuticals.

1989 • 1,071 citations

The human interferons—From protein purification and sequence to cloning and expression in bacteria: Before, between, and beyond

1983 • 236 citations

Role of Aggregated Human Growth Hormone (hGH) in Development of Antibodies to hGH*

1980 • 216 citations

Treatment of chronic type B hepatitis with recombinant α-interferon induces autoantibodies not specific for autoimmune chronic hepatitis

1989 • 175 citations

Preparation of human growth hormone by gel filtration

1963 • 130 citations

Immunologic Reactions to Insulin: Insulin Allergy, Insulin Resistance, and the Autoimmune Insulin Syndrome

1979 • 124 citations

Interferon kinetics and adverse reactions after intravenous, intramuscular, and subcutaneous injection

1984 • 116 citations

Recombinant Leukocyte Interferon Alpha-2A and Medroxyprogesterone in Advanced Renal Cell Carcinoma: A Randomized Trial

1990 • 86 citations

Anti-interferon antibodies: a perspective.

1988 • 61 citations

Antibody Production to Aggregated Human γg-Globulin in Acquired Hypogammaglobulinemia

1968 • 48 citations

Assessment of the antigenic response in humans to a recombinant mutant interferon beta

1987 • 47 citations

Development and use of enzyme-linked immunosorbent assays (ELISA) for the detection of protein aggregates in interferon-alpha (IFN-alpha) formulations.

1997 • 30 citations

Naturally Occurring Autoantibodies to Interleukin-1α, Interleukin-6, Interleukin-10, and Interferon-α

1994 • 28 citations

Influence of one virus infection on a second concurrent primary in vivo antiviral cytotoxic T-cell response

1983 • 24 citations

Specificities of Therapy-Induced Anti-Interferon-α Antibodies

1994 • 13 citations

Route‐Related Variation in the Immunogenicity of Killed Salmonella enteritidis Vaccine: Role of Antigen Presenting Cells

1989 • 11 citations