HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis.

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 • 539 citations

T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination

1985 • 522 citations

A molecular map of the immune response region from the major histocompatibility complex of the mouse

1982 • 466 citations

Conserved organization of the human and murine T-cell receptor β-gene families

1988 • 388 citations

Promiscuous and allele-specific anchors in HLA-DR-binding peptides

1993 • 383 citations

Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals.

1990 • 342 citations

Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors.

1990 • 307 citations

Identification of a CD4 binding site on the β2 domain of HLA-DR molecules

1992 • 272 citations

Antigen presentation mediated by recycling of surface HLA-DR molecules

1995 • 271 citations

HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis.

1996 • 203 citations

Complete primary structures of the E beta chain and gene of the mouse major histocompatibility complex.

1983 • 161 citations

Diversity in fine specificity and T cell receptor usage of the human CD4+ cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106.

1992 • 148 citations

Relapsing murine experimental allergic encephalomyelitis induced by myelin basic protein.

1983 • 130 citations

High-affinity binding of short peptides to major histocompatibility complex class II molecules by anchor combinations.

1994 • 127 citations

T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans.

1995 • 121 citations

Human major histocompatibility complex class II-restricted T cell responses in transgenic mice.

1994 • 108 citations

Encephalitogenic activity of guinea pig myelin basic protein in the SJL mouse.

1982 • 95 citations

Analysis of gene structure and antigen determinants of DR2 antigens using DR gene transfer into mouse L cells.

1989 • 94 citations

Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T-cell repertoire and mediates an HLA-DR-restricted immune response.

1994 • 90 citations

The T cell response of HLA-DR transgenic mice to human myelin basic protein and other antigens in the presence and absence of human CD4.

1995 • 89 citations

DM-20, a proteolipid apoprotein, is an encephalitogen of acute and relapsing autoimmune encephalomyelitis in mice.

1986 • 67 citations

Complex regulation of class II gene expression: analysis with class II mutant cell lines.

1985 • 67 citations

Transgenic HLA-DRα faithfully reconstitutes IE-controlled immune functions and induces cross-tolerance to Eα in Eα0 mutant mice

1989 • 64 citations

The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire.

1995 • 64 citations

Segregation patterns of endogenous mouse mammary tumor viruses in five recombinant inbred strain sets

1990 • 60 citations

HLA-DR polymorphism affects the interaction with CD4.

1995 • 44 citations

T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice.

1994 • 32 citations

Down-regulation of class II major histocompatibility complex molecules on antigen-presenting cells by antibody fragments

1995 • 12 citations