Cytokine hypothesis of overtraining: a physiological adaptation to excessive stress?

The Stress of Life

1956 • 5,480 citations

Biological basis of the behavior of sick animals

1988 • 2,123 citations

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

Cytokines for psychologists: Implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition.

1998 • 1,130 citations

Evidence for an immune response in major depression: A review and hypothesis

1995 • 954 citations

Cytokines and the nervous system II: actions and mechanisms of action

1995 • 928 citations

The macrophage theory of depression

1991 • 871 citations

Sickness behavior as a new target for drug development

1992 • 866 citations

Multiple Cytokines and Acute Inflammation Raise Mouse Leptin Levels: Potential Role in Inflammatory Anorexia

1997 • 798 citations

Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro

1991 • 729 citations

Psychological monitoring of overtraining and staleness.

1987 • 640 citations

Interleukin-6 in the Injured Patient

1996 • 500 citations

Exercise-induced muscle damage, repair, and adaptation in humans

1988 • 497 citations

Acute inflammation

1991 • 470 citations

Neuropsychopharmacology

2023 • 466 citations

Overtraining in Athletes

1991 • 456 citations

Cytokines and macrophages

1994 • 442 citations

Interleukin-1β (IL-1β) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro

1996 • 425 citations

Exercise, Infection, and Immunity

1994 • 417 citations

Delayed Muscle Soreness

1995 • 372 citations

Epidemiological patterns of musculoskeletal injuries and physical training

1999 • 364 citations

Effects of repeated days of intensified training on muscle glycogen and swimming performance

1988 • 358 citations

Hypothalamic Dysfunction in Overtrained Athletes*

1985 • 311 citations

Exercise and cytokines

2000 • 310 citations

Update on the Mechanisms of Immune Suppression of Injury and Immune Modulation

1996 • 297 citations

Resistance Exercise Overtraining and Overreaching

1997 • 278 citations

Depression‐related disturbances in mitogen‐induced lymphocyte responses and interleukin‐1β and soluble interleukin‐2 receptor production

1991 • 259 citations

Muscle amino acid metabolism at rest and during exercise: role in human physiology and metabolism.

1998 • 229 citations

Interleukin 1 receptors in the brain and endocrine tissues

1993 • 228 citations

Autonomic imbalance hypothesis and overtraining syndrome

1998 • 221 citations

Lore of Running

1992 • 210 citations

Role of pro- and anti-inflammatory cytokines during inflammation: experimental and clinical findings.

1997 • 206 citations

Impaired pituitary hormonal response to exhaustive exercise in overtrained endurance athletes

1998 • 197 citations

Cytokines and the liver

1997 • 189 citations

Elevated serum antioxidant capacity and plasma malondialdehyde concentration in response to a simulated half-marathon run

1998 • 188 citations

Interleukin-6 and the Interleukin-6 Receptor in the Human Adrenal Gland: Expression and Effects on Steroidogenesis1

1997 • 179 citations

Eccentric exercise-induced muscle damage impairs muscle glycogen repletion

1987 • 172 citations

Impaired muscle glycogen resynthesis after eccentric exercise

1990 • 171 citations

Review: The Role of Cytokines in the Catabolic Consequences of Infection and Injury

1998 • 166 citations

Eccentric exercise induces transient insulin resistance in healthy individuals

1992 • 160 citations

Effect of High- Versus Moderate-Intensity Exercise on Lymphocyte Subpopulations and Proliferative Response

1994 • 158 citations

Interleukin-1 Inhibits the Ovarian Steroid-Induced Luteinizing Hormone Surge and Release of Hypothalamic Luteinizing Hormone-Releasing Hormone in Rats*

1990 • 154 citations

Training and overtraining: an introduction

1998 • 152 citations

Strenuous exercise: analogous to the acute-phase response?

1991 • 147 citations

Overtraining in Sport

1997 • 142 citations

Local administration of recombinant human interleukin-1 beta in the rat hippocampus increases serotonergic neurotransmission, hypothalamic-pituitary-adrenocortical axis activity, and body temperature.

1994 • 141 citations

The evolution and adaptive value of fever.

1978 • 141 citations

NEUROIMMUNOMODULATION VIA LIMBIC STRUCTURES — THE NEUROANATOMY OF PSYCHOIMMUNOLOGY

1997 • 137 citations

Eccentric exercise decreases glucose transporter GLUT4 protein in human skeletal muscle.

1995 • 133 citations

The haematological, biochemical and immunological profile of athletes suffering from the overtraining syndrome

1995 • 122 citations

Eccentric exercise decreases maximal insulin action in humans: muscle and systemic effects.

1996 • 99 citations

Prolonged submaximal eccentric exercise is associated with increased levels of plasma IL-6

1997 • 98 citations

Overtraining: A Review of the Signs, Symptoms and Possible Causes

1991 • 95 citations

Overtraining and glycogen depletion hypothesis

1998 • 89 citations

Hypoxia/reoxygenation stimulates endothelial cells to promote interleukin-1 and interleukin-6 production. Effects of free radical scavengers

1992 • 87 citations

C reactive protein concentrations during long distance running.

1984 • 80 citations

Overtraining and immune system: a prospective longitudinal study in endurance athletes

1998 • 77 citations

Serotonin-immune interactions in major depression: lower serum tryptophan as a marker of an immune-inflammatory response

1997 • 76 citations

Cytokines and cytokine receptors

1997 • 74 citations

Branch-chain amino acids

1990 • 73 citations

Psychomotor retardation, anorexia, weight loss, sleep disturbances, and loss of energy: Psychopathological correlates of hyperhaptoglobinemia during major depression

1993 • 72 citations

Lower Serum L-Tryptophan Availability in Depression as a Marker of a More Generalized Disorder in Protein Metabolism

1996 • 70 citations

Physical activity, training, and the immune response

1997 • 60 citations

Cytokines and glucocorticoids in the regulation of the “hepato-skeletal muscle axis” in sepsis

1991 • 59 citations

Overtraining and the BCAA hypothesis

1998 • 57 citations

Hardiness and Mood Disturbances in Swimmers while Overtraining

1994 • 51 citations

Acute and Chronic Over-Exertion: Do Depressed Immune Responses Provide Useful Markers?

1998 • 51 citations

Cytokines and reproduction.

1994 • 38 citations

Luteinizing Hormone‐Releasing Hormone Is a Primary Signaling Molecule in the Neuroimmune Network

1998 • 37 citations

Exercise and Infection

1987 • 35 citations

Th1- and Th2-Type Cytokines Regulate Chemokine Expression

1996 • 33 citations

Metabolism after trauma and in sepsis.

1986 • 33 citations

Increased Training Volume in Strength\Power Athletes

1998 • 27 citations

The relationship of IL-6 to hormonal mediators, fuel utilization, and systemic hypermetabolism after surgical trauma.

1996 • 26 citations

A Biochemical Mechanism to Explain Some Characteristics of Overtraining

2015 • 26 citations

The Exercise Myopathy

2007 • 19 citations

Metabolic studies of acute-phase proteins

1984 • 18 citations

Exercise, injury and chronic inflammatory lesions

1992 • 17 citations

ELEVATED SERUM CYTOKINES ASSOCIATED WITH PLANTAR FASCIITIS

1999 • 2 citations

THE EFFECT OF COMBINED VERSUS ECCENTRIC TRAINING ON MARKERS OF OVERSTRESS298

1997 • 1 citations

Why does Leptin increase? Could it be a future index of fatigue -

1998 • 1 citations

Deleted Work

1955 • 0 citations