Interleukin-6 and the Interleukin-6 Receptor in the Human Adrenal Gland: Expression and Effects on Steroidogenesis1

The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation

1995 • 2,525 citations

The biology of interleukin-6

1989 • 1,964 citations

The biology of interleukin-6

1989 • 1,459 citations

Interleukin-6 and Its Receptor: A Paradigm for Cytokines

1992 • 889 citations

Neuroendocrine-Immune Interactions

1993 • 571 citations

Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans.

1993 • 555 citations

Exposure to physical and psychological stressors elevates plasma interleukin 6: relationship to the activation of hypothalamic-pituitary-adrenal axis.

1993 • 488 citations

Interleukin-6 stimulates the secretion of adrenocorticotropic hormone in conscious, freely-moving rats

1988 • 428 citations

Network of immune-neuroendocrine interactions.

1977 • 413 citations

Interleukins-1 and -6 Stimulate the Release of Corticotropin-Releasing Hormone-41 from Rat Hypothalamusin Vitrovia the Eicosanoid Cyclooxygenase Pathway*

1991 • 331 citations

Control of Adrenal Androgen Secretion*

1980 • 271 citations

Hypothalamic-pituitary-adrenal axis activation and stimulation of systemic vasopressin secretion by recombinant interleukin-6 in humans: potential implications for the syndrome of inappropriate vasopressin secretion.

1994 • 251 citations

Phase I trial of subcutaneous interleukin-6 in patients with advanced malignancies.

1993 • 223 citations

The Effect of Interleukin-6 on Pituitary Hormone Release in vivo and in vitro

1991 • 181 citations

Interleukin-6 and ACTH act synergistically to stimulate the release of corticosterone from adrenal gland cells

1990 • 177 citations

Cortisol and Corticotrophin in Burned Patients

1982 • 156 citations

Effects of recombinant human interleukin-1α, -1β, 2 and 6 on ACTH synthesis and release in the mouse pituitary tumour cell line AtT-20

1989 • 145 citations

Prostaglandin-Dependent in Vitro Stimulation of Adrenocortical Steroidogenesis by Interleukins*

1991 • 145 citations

Interleukin-6 stimulates the hypothalamus-pituitary-adrenocortical axis in man.

1994 • 138 citations

Interleukin-6 in clinical medicine

1991 • 131 citations

The effects of recombinant human interleukin (IL)-1α, IL-1β or IL-6 on hypothalamo-pituitary-adrenal axis activation

1992 • 125 citations

Analysis of cytokine receptor messenger RNA expression in human glioblastoma cells and normal astrocytes by reverse-transcription polymerase chain reaction

1994 • 114 citations

Cytokines Stimulate the CRH but Not the Vasopressin Neuronal System: Evidence for a Median Eminence Site of Interleukin-6 Action

1992 • 112 citations

QUANTITATIVE PCR ANALYSIS OF CYTOKINE TRANSCRIPTION PATTERNS IN PERIPHERAL MONONUCLEAR CELLS AFTER ANTI-CD3 REJECTION THERAPY USING TWO NOVEL MULTISPECIFIC COMPETITOR FRAGMENTS1

1994 • 79 citations

Binding Sites for Interleukin-6 in the Anterior Pituitary Gland

1992 • 74 citations

Endocrine–paracine interaction in communication between the immune and endocrine systems. Activation of the hypothalamic-pituitary-adrenal axis in inflammation

1994 • 74 citations

Evidence for Extrapituitary Mechanisms Mediating the Morning Peak of Plasma Cortisol in Man*

1984 • 71 citations

A Central Mechanism Is Involved in the Secretion of ACTH in Response to IL-6 in Rats: Comparison to and Interaction with IL-1β

1992 • 70 citations

Macrophages within the human adrenal gland

1994 • 68 citations

Interleukin-6 messenger ribonucleic acid expression in human adrenal gland in vivo: new clue to a paracrine or autocrine regulation of adrenal function.

1994 • 66 citations

Sympathoadrenal regulation of adrenocortical steroidogenesis

1995 • 63 citations

Adrenocorticotropin increases interleukin-6 release from rat adrenal zona glomerulosa cells.

1992 • 62 citations

Role of the Vasoactive Intestinal Peptide in a Neuroendocrine Regulation of the Adrenal Cortex

1991 • 56 citations

Expression of interleukin-6 (IL-6) and IL-6 receptor mRNAs in rat adrenal medulla

1995 • 46 citations

Glucocorticoids modulate rat hypothalamic corticotrophin‐releasing factor release induced by interleukin‐1

1989 • 44 citations

Sympathoadrenal system and immune system in the regulation of adrenocortical function

1996 • 43 citations

Interleukin-6 messenger ribonucleic acid expression in human adrenal gland in vivo: new clue to a paracrine or autocrine regulation of adrenal function

1994 • 36 citations

Sympathoadrenal Regulation of Adrenal Androstenedione Release

1994 • 30 citations

Evidence for ACTH-unrelated mechanisms in the regulation of cortisol secretion in man

1984 • 28 citations