Serotonin-immune interactions in major depression: lower serum tryptophan as a marker of an immune-inflammatory response

A Coefficient of Agreement for Nominal Scales

1960 • 37,524 citations

A RATING SCALE FOR DEPRESSION

1960 • 30,921 citations

Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R)

1987 • 1,599 citations

Evidence for an immune response in major depression: A review and hypothesis

1995 • 954 citations

Psychopharmacology: The Fourth Generation of Progress

1995 • 842 citations

Tryptophan depletion causes a rapid lowering of mood in normal males

1985 • 726 citations

The Specific Binding of l-Tryptophan to Serum Albumin

1958 • 638 citations

Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression

1995 • 614 citations

Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression

1993 • 440 citations

THE EFFECTS OF PRECURSOR LOADING IN THE CEREBRAL METABOLISM OF 5‐HYDROXYINDOLES

1968 • 399 citations

Interleukin-1 beta: a putative mediator of HPA axis hyperactivity in major depression?

1993 • 359 citations

Interleukin‐6 Serum Levels in Depressed Patients before and after Treatment with Fluoxetine

1995 • 301 citations

Increased neopterin and interferon-gamma secretion and lower availability of L-tryptophan in major depression: Further evidence for an immune response

1994 • 298 citations

Hypozincemia in depression

1994 • 217 citations

Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms.

1990 • 203 citations

EFFECT OF ALBUMIN BINDING AND AMINO ACID COMPETITION ON TRYPTOPHAN UPTAKE INTO BRAIN

1977 • 200 citations

Changes in immunoglobulin, complement and acute phase protein levels in the depressed patients and normal controls

1994 • 190 citations

L-Tryptophan: Biochemical, nutritional and pharmacological aspects

1996 • 168 citations

Relationships between lower plasma L-tryptophan levels and immune-inflammatory variables in depression

1993 • 154 citations

Monoamine-related markers of depression: Changes following treatment

1982 • 153 citations

Effect of amino acid limitation on the expression of 19 genes in rat hepatoma cells

1994 • 140 citations

Inter-relationships between quinolinic acid, neuroactive kynurenines, neopterin and β2-microglobulin in cerebrospinal fluid and serum of HIV-1-infected patients

1992 • 136 citations

A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation

1990 • 133 citations

Interleukin 1, tumour necrosis factor‐alpha (cachectin) and the pathogenesis of cancer cachexia

1987 • 129 citations

Neuroendocrine and behavioral effects of dietary tryptophan restriction in healthy subjects

1989 • 126 citations

Major depressive disorder is associated with elevated monocyte counts

1996 • 122 citations

A test of possible cognitive and environmental influences on the mood lowering effect of tryptophan depletion in normal males

1987 • 122 citations

Plasma Tryptophan and Five Other Amino Acids in Depressed and Normal Subjects

1981 • 119 citations

Increased CD56+Natural Killer Cells and Related Cytokines in Major Depression

1996 • 110 citations

Dietary regulation of brain tryptophan metabolism by plasma ratio of free tryptophan and neutral amino acids in humans

1974 • 110 citations

Tryptophan transport through the blood-brain barrier: In vivo measurement of free and albumin-bound amino acid

1979 • 95 citations

Changes on recovery in the concentrations of tryptophan and the biogenic amine metabolites in the cerebrospinal fluid of patients with affective illness

1973 • 94 citations

Alterations in iron metabolism and the erythron in major depression: Further evidence for a chronic inflammatory process

1996 • 81 citations

Lower Serum L-Tryptophan Availability in Depression as a Marker of a More Generalized Disorder in Protein Metabolism

1996 • 70 citations

Concentration and microheterogeneity glycophorms of alpha-1-acid glycoprotein in major depressive disorder

1996 • 52 citations

Plasma Tryptophan to Large Neutral Amino Acids Ratio and Therapeutic Response to a Selective Serotonin Uptake Inhibitor

1994 • 48 citations

Haptoglobin phenotypes and gene frequencies in unipolar major depression

1994 • 45 citations

Plasma tryptophan and tyrosine ratios to competing amino acids in relation to antidepressant response to citalopram and maprotiline

1986 • 42 citations

Tryptophan to competing amino acids ratio in depressive disorder: relation to efficacy of antidepressive treatments

1985 • 40 citations

The CD4/CD8 Ratio in the Blood Does Not Reflect the Response of This Index in Secondary Lymphoid Organs of Weanling Mice in Models of Protein-Energy Malnutrition Known to Depress Thymus-Dependent Immunity

1996 • 39 citations

Tryptophan-deficient diet and amino acid drink deplete plasma tryptophan and induce a relapse of depression in susceptible patients

1992 • 34 citations

Adrenoreceptor interactions of the enantiomers and metabolites of mianserin: are they responsible for the antidepressant effect?

1985 • 32 citations

Free and protein-bound tryptophan in serum of untreated patients with chronic renal failure

1993 • 29 citations

The effects of glucocorticoids on the availability of L-tryptophan and tyrosine in the plasma of depressed patients

1990 • 29 citations

Oxidative tryptophan metabolism in renal allograft recipients: Increased kynurenine synthesis is associated with inflammation and OKT3 therapy

1992 • 29 citations

Plasma tryptophan to large neutral amino acid ratios in depressed and normal subjects

1990 • 28 citations

Psychoneuroimmunology

1995 • 27 citations

Evidence for the Existence of Major Depression with and without Anxiety Features

1994 • 27 citations

Polymorphonuclear (PMN) elastase levels in depressive disorders

1996 • 22 citations

Amino acids in psychiatric disease

1990 • 18 citations

Influence of cerebral blood flow on tryptophan uptake into brain

1990 • 14 citations

Haptoglobin levels in a chronic mild stress model of depression in rats before and after treatment

1994 • 13 citations

Tryptophan Transport to the Brain: Newer Findings and Older Ones Reconsidered

1984 • 13 citations

Tryptophan Availability and Serotonin Synthesis in Rat Brain: Effects of Experimental Diabetes

1984 • 11 citations

Relationships between lower plasma L-tryptophan levels and immune variables in depression

1993 • 7 citations

The Relationship between Plasma Kynurenine and Indoleamine 2,3-Dioxygenase Activity in the Extrahepatic Tissues

1984 • 7 citations

Deleted Work

1955 • 0 citations