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Elevated expression of inhibitor of apoptosis proteins in prostate cancer.

Data up to Jan 2025

Published2003
Citations241
References48

Total Citations Per Year

Abstract

References (48)

TNM Classification of Malignant Tumours

1987 • 16,209 citations

Tissue microarrays for high-throughput molecular profiling of tumor specimens

1998 • 4,104 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

Caspase structure, proteolytic substrates, and function during apoptotic cell death

1999 • 1,540 citations

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

1997 • 1,316 citations

Prostate cancer in a transgenic mouse.

1995 • 1,295 citations

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.

1998 • 1,243 citations

Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic Stimuli

2000 • 989 citations

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

2001 • 987 citations

The inhibitors of apoptosis (IAPs) and their emerging role in cancer

1998 • 985 citations

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

2000 • 842 citations

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

2002 • 739 citations

Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase Interaction

2002 • 732 citations

Nuclear Factor (NF)-κB–regulated X-chromosome–linked iap Gene Expression Protects Endothelial Cells from Tumor Necrosis Factor α–induced Apoptosis

1998 • 643 citations

Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.

2000 • 617 citations

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

1999 • 613 citations

A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases

1998 • 611 citations

HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins

2002 • 550 citations

Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia

1999 • 544 citations

Identification of XAF1 as an antagonist of XIAP anti-Caspase activity

2001 • 434 citations

Role of programmed (apoptotic) cell death during the progression and therapy for prostate cancer

1996 • 421 citations

ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas

2000 • 407 citations

Survivin apoptosis: an interloper between cell death and cell proliferation in cancer.

1999 • 284 citations

Synthetic Smac/DIABLO Peptides Enhance the Effects of Chemotherapeutic Agents by Binding XIAP and cIAP1 in Situ

2002 • 263 citations

The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice.

1994 • 259 citations

Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death

2000 • 255 citations

Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide.

2003 • 238 citations

Activation of NF-κB by XIAP, the X Chromosome-linked Inhibitor of Apoptosis, in Endothelial Cells Involves TAK1

2000 • 227 citations

IAP Suppression of Apoptosis Involves Distinct Mechanisms: the TAK1/JNK1 Signaling Cascade and Caspase Inhibition

2002 • 222 citations

A Human IAP-Family Gene, Apollon, Expressed in Human Brain Cancer Cells

1999 • 217 citations

The Survivin saga goes in vivo

2001 • 212 citations

Down-regulation of Survivin by Antisense Oligonucleotides Increases Apoptosis, Inhibits Cytokinesis and Anchorage-Independent Growth

2000 • 205 citations

Ion Channel Activity of the BH3 Only Bcl-2 Family Member, BID

1999 • 195 citations

Human Ovarian Cancer and Cisplatin Resistance: Possible Role of Inhibitor of Apoptosis Proteins1

2001 • 183 citations

Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative–(BMS 247550) and Apo-2L/TRAIL–induced apoptosis

2002 • 162 citations

SMAC Negatively Regulates the Anti-apoptotic Activity of Melanoma Inhibitor of Apoptosis (ML-IAP)

2002 • 161 citations

BIRinging Chromosomes through Cell Division—And Survivin' the Experience

2000 • 153 citations

xIAP Induces Cell-Cycle Arrest and Activates Nuclear Factor-κB

2001 • 135 citations

Selective activation of JNK1 is necessary for the anti-apoptotic activity of hILP

1998 • 134 citations

Evolutionary conservation of apoptosis mechanisms: Lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9

2000 • 127 citations

BAG-1: A Novel Biomarker Predicting Long-Term Survival in Early-Stage Breast Cancer

2001 • 107 citations

Detection of Multiple Antigens on Western Blots

1996 • 103 citations

Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesothelioma

2002 • 73 citations

Adoptive immunotherapy prevents prostate cancer in a transgenic animal model

1999 • 64 citations

Advances and controversies in the study of programmed cell death/apoptosis in the development of and therapy for cancer

1994 • 40 citations

Smac is required for cytochrome c-induced apoptosis in prostate cancer LNCaP cells.

2002 • 38 citations

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Elevated expression of inhibitor of apoptosis proteins in prostate cancer. (2003) – PubMed | Metascience Observatory Explorer